MS Detection of Somatic Mutations in Hematological Malignancies (MAHM)
Evaluation of MassArray Platform Versus Illumina Miseq for the Detection of Driver Mutations in Hematological Malignancies
Detection of somatic mutations in hematological malignancies is now routinely assessed by NGS sequencing. This powerful approach is nevertheless time consuming and its costs represent limitation for its availability. An original approach is now available, using mass spectrometry (MS). In this study the analytical performance of both methods will be compared, using samples that were previously analyzed by NGS.
The goal of the study is to assess whether MS can represent or not a faster and cheaper way to detect key point mutations in patients suffering from hematological malignancies
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名：Laurent MAUVIEUX, MD, PhD
- 电话号码：33 3 88 12 75 27
- 邮箱：laurent.mauvieux@chru-strasbourg.fr
学习地点
-
-
-
Strasbourg、法国、67098
- 招聘中
- Laboratoire d'Hématologie
-
接触：
- Laurent MAUVIEUX, MD, PhD
- 电话号码：33 3 88 12 75 27
- 邮箱：laurent.mauvieux@chru-strasbourg.fr
-
接触：
- Laurent MIGUET, MD
- 电话号码：33 3 88 12 75 27
- 邮箱：Laurentyannick.miguet@chru-strasbourg.fr
-
首席研究员：
- Laurent MAUVIEUX, MD, PhD
-
副研究员：
- Laurent MIGUET, MD
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- adults >18 years old
- anonymized samples already studied with NGS in Strasbourg university hematology center for somatic mutations
- non-opposition of the patient for testing the archive sample with the new method
Exclusion Criteria:
- opposition for testing the archive sample with the new method
- insufficient archival material
- patient under protection
学习计划
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：追溯
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Detection of somatic mutations in hematological malignancies by using mass spectrometry (MS)
大体时间：10 months
|
Detection of somatic mutations in hematological malignancies is now routinely assessed by NGS sequencing.
This powerful approach is nevertheless time consuming and its costs represent limitation for its availability.
An original approach is now available, using mass spectrometry (MS).
In this study the analytical performance of both methods will be compared, using samples that were previously analyzed by NGS.
|
10 months
|
合作者和调查者
调查人员
- 首席研究员：Laurent MAUVIEUX, MD, PhD、University Hospital, Strasbourg, France
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.