Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction
The Effect of Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction (a Randomized Controlled Clinical Trial)
研究概览
地位
条件
详细说明
A randomized controlled clinical trial will be conducted to address the aim of the study. Sixteen patients will be recruited, requiring the therapeutic extraction of the maxillary 1st premolars, with subsequent canine retraction into the extraction space. The sample will be randomly divided into 2 equal groups, each including 8 subjects.
In Group A, one side of the maxillary arch will randomly receive LLLT on days 0, 3, 7, 14, and every 2 weeks thereafter, while in Group B, one side will also be randomly chosen to receive LLLT every 3 weeks. The contralateral sides of both groups will serve as the controls. The LLLT applied will be Diode laser emitting infrared radiation at wavelength of 980 nm, in a continuous mode.
Canine retraction in both groups will be carried out bilaterally using nickel-titanium closed-coil spring, delivering 150 grams of force, and the rate of tooth movement will be checked every 3 weeks, over a period of 3 months. Other variables will be also examined including, interleukin-1β level in the gingival crevicular fluid, root resorption, and molar anchorage loss.
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
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Alexandria、埃及
- Alexandria Faculty of Dentistry
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Malocclusion requires at least the extraction of maxillary first premolars, followed by canine retraction into the extraction site.
- Normal shape and structure of the maxillary canines, with no history of root canal treatment.
- Patients with good oral hygiene, and a healthy periodontal condition.
Exclusion Criteria:
- Patients who underwent previous orthodontic treatment.
- Patients currently receiving drug therapy that may affect orthodontic tooth movement, e.g. hormonal therapy and corticosteroids.
- Patients with chronic diseases that may affect the rate of tooth movement.
- Pregnancy and lactation
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：low-level laser therapy applied on days 0, 3,7,14 & every 2 weeks
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one side of the maxillary arch will randomly receive LLLT on days 0, 3, 7, 14, and every 2 weeks thereafter and the contralateral side will serve as the controls.
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有源比较器：low-level laser therapy applied every 3 weeks
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one side will also be randomly chosen to receive LLLT every 3 weeks and the contralateral side will serve as the controls.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in rate of canine retraction
大体时间：at baseline and every 3 weeks for 3 months
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Several landmarks will be identified on the dental cast, including the mid-palatal raphe, the most medial points on the third right and left rugae, and the cusp tips of the right and left maxillary canines.
Perpendicular lines will be drawn from the medial points of the right and left third rugae, and the cusp tips of the right and left maxillary canines to the mid-palatal raphe.
The antero-posterior measurements will be carried out between the canine lines and the third rugae lines bilaterally, to assess the rate of canine retraction.
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at baseline and every 3 weeks for 3 months
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change in IL-1β level in the Ginigval Crevicular Fluid
大体时间：at baseline, 7th, 17th and 21st day
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Samples from the GCF will be collected at baseline (before the first canine retraction), in addition to days 7, 14, and 21.
GCF samples will be collected from the distal crevices of the canines, in Groups A and B, on both the experimental and control sides.
Measurement of IL-1β level in the GCF will be performed using an ELISA kit.
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at baseline, 7th, 17th and 21st day
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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change canine root resorption:
大体时间：at baseline and 3 months
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Root resorption of the maxillary canines will be evaluated and measured on the acquired pre-retraction and post-retraction CBCT scans.
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at baseline and 3 months
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Change molar anchorage loss
大体时间：at baseline and every 3 weeks for 3 months
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Perpendicular lines will be drawn from the central fossae of both maxillary right and left first molars to the mid-palatal raphe.
Consequently, molar anchorage loss will be calculated by measuring the distance between those lines, and the lines representing the third rugae as previously mentioned.
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at baseline and every 3 weeks for 3 months
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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