Selenoprotein and Renalase Blood Levels in Patients With Hypertensive Heart Disease and Obstructive Sleep Apnea
The Role of Selenoprotein Activity and Blood Renalase Level in the Pathogenesis of Hypertension and Obstructive Sleep Apnea
研究概览
详细说明
The study will be conducted in the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at Borowska 213 street in Wroclaw. This decision follows the high percentage of people with obstructive sleep apnea and hypertension among those hospitalized in the Clinic and also the wide availability of research tools in the hospital.
150 more patients with hypertension and obstructive sleep apnea will be included in the planned observational study.
The study is observational, research procedures are non-invasive and no additional medical experiment is planned. The study was approved by the Bioethics Committee of the Wroclaw Medical University.
Patients enrolled in the study will be asked to share the results of their previously performed examinations or, in case they do not have any, new examinations will be performed to complement the diagnostic process of hypertension and obstructive sleep apnea.
The planned procedures include: medical interview, physical examination with basic anthropometric measurements (age, height, body weight); biochemical tests including blood selenium, selenoproteins, renalase and creatinine levels; total antioxidant status (TAS), 24-hour Holter electrocardiography, polysomnography, ultrasound assessment of peripheral vascular endothelial function and echocardiography.
Laboratory tests will be performed using commercially available standardized tests. The levels of selenoproteins, renalase and creatinine in the blood, as well as TAS will be determined by ELISA (Enzyme-linked immunosorbent assay) in accordance with the instructions. Blood selenium level will be measured by means of atomic absorption spectrometry (AAS). 24-hour Holter ECG monitoring will be performed using a Lifecard CF recorder, followed by an analysis of the record by the Impresario Solo system (Delmar Reynolds, Hertford, UK). Ultrasound examination will be performed using the ProSound Alpha 6 (Aloka Inc, Tokyo, Japan).
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Karolina Czerwińska, MD
- 电话号码:+48 790 404 619
- 邮箱:karolina.czerwinska@student.umed.wroc.pl
研究联系人备份
- 姓名:Paweł Gać, ASSOC PROF
- 电话号码:+48 71 784 15 01
- 邮箱:pawel.gac@umed.wroc.pl
学习地点
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Dolnośląskie
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Wrocław、Dolnośląskie、波兰、50-368
- 招聘中
- Department of Hygiene, Wroclaw Medical University
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接触:
- Paweł Gać, ASSOC PROF
- 电话号码:+48 71 784 15 01
- 邮箱:pawel.gac@umed.wroc.pl
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- arterial hypertension
Exclusion Criteria:
- age <18
- pregnancy
- refusal to participate in the study
学习计划
研究是如何设计的?
设计细节
- 观测模型:仅案例
- 时间观点:横截面
队列和干预
团体/队列 |
---|
Group 1
The planned procedures include: medical interview, physical examination with basic anthropometric measurements (age, height, body weight); biochemical tests including blood selenium, selenoproteins, renalase and creatinine levels; total antioxidant status (TAS), 24-hour Holter electrocardiography, polysomnography and echocardiography. A 10 ml of venous blood sample will be collected by venopuncture. Laboratory tests will be performed using commercially available standardized tests. |
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Assesment of blood renalase level
大体时间:One day
|
The Enzyme-linked immunosorbent assay (ELISA) to know blood renalase level
|
One day
|
Assesment of blood selenoprotein P level
大体时间:One day
|
The Enzyme-linked immunosorbent assay (ELISA) to know blood selenoprotein P level
|
One day
|
Assesment of the severity of obstructive sleep apnea
大体时间:One day
|
Full polysomnography
|
One day
|
Assessment of arrhythmias
大体时间:One day
|
24-hour Holter ECG monitoring
|
One day
|
Assessment of arrhythmias and cardiac morphology
大体时间:One day
|
Echocardiography
|
One day
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Assesment of Blood Total Antioxidant Status (TAS)
大体时间:One day
|
The Enzyme-linked immunosorbent assay (ELISA) to know Blood Total Antioxidant Status (TAS)
|
One day
|
合作者和调查者
调查人员
- 学习椅:Paweł Gać, ASSOC PROF、Wroclaw Medical University
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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