Selenoprotein and Renalase Blood Levels in Patients With Hypertensive Heart Disease and Obstructive Sleep Apnea
The Role of Selenoprotein Activity and Blood Renalase Level in the Pathogenesis of Hypertension and Obstructive Sleep Apnea
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
The study will be conducted in the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at Borowska 213 street in Wroclaw. This decision follows the high percentage of people with obstructive sleep apnea and hypertension among those hospitalized in the Clinic and also the wide availability of research tools in the hospital.
150 more patients with hypertension and obstructive sleep apnea will be included in the planned observational study.
The study is observational, research procedures are non-invasive and no additional medical experiment is planned. The study was approved by the Bioethics Committee of the Wroclaw Medical University.
Patients enrolled in the study will be asked to share the results of their previously performed examinations or, in case they do not have any, new examinations will be performed to complement the diagnostic process of hypertension and obstructive sleep apnea.
The planned procedures include: medical interview, physical examination with basic anthropometric measurements (age, height, body weight); biochemical tests including blood selenium, selenoproteins, renalase and creatinine levels; total antioxidant status (TAS), 24-hour Holter electrocardiography, polysomnography, ultrasound assessment of peripheral vascular endothelial function and echocardiography.
Laboratory tests will be performed using commercially available standardized tests. The levels of selenoproteins, renalase and creatinine in the blood, as well as TAS will be determined by ELISA (Enzyme-linked immunosorbent assay) in accordance with the instructions. Blood selenium level will be measured by means of atomic absorption spectrometry (AAS). 24-hour Holter ECG monitoring will be performed using a Lifecard CF recorder, followed by an analysis of the record by the Impresario Solo system (Delmar Reynolds, Hertford, UK). Ultrasound examination will be performed using the ProSound Alpha 6 (Aloka Inc, Tokyo, Japan).
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiekontakt
- Navn: Karolina Czerwińska, MD
- Telefonnummer: +48 790 404 619
- E-mail: karolina.czerwinska@student.umed.wroc.pl
Undersøgelse Kontakt Backup
- Navn: Paweł Gać, ASSOC PROF
- Telefonnummer: +48 71 784 15 01
- E-mail: pawel.gac@umed.wroc.pl
Studiesteder
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Dolnośląskie
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Wrocław, Dolnośląskie, Polen, 50-368
- Rekruttering
- Department of Hygiene, Wroclaw Medical University
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Kontakt:
- Paweł Gać, ASSOC PROF
- Telefonnummer: +48 71 784 15 01
- E-mail: pawel.gac@umed.wroc.pl
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-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- arterial hypertension
Exclusion Criteria:
- age <18
- pregnancy
- refusal to participate in the study
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: Kun etui
- Tidsperspektiver: Tværsnit
Kohorter og interventioner
Gruppe / kohorte |
|---|
|
Group 1
The planned procedures include: medical interview, physical examination with basic anthropometric measurements (age, height, body weight); biochemical tests including blood selenium, selenoproteins, renalase and creatinine levels; total antioxidant status (TAS), 24-hour Holter electrocardiography, polysomnography and echocardiography. A 10 ml of venous blood sample will be collected by venopuncture. Laboratory tests will be performed using commercially available standardized tests. |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Assesment of blood renalase level
Tidsramme: One day
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The Enzyme-linked immunosorbent assay (ELISA) to know blood renalase level
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One day
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Assesment of blood selenoprotein P level
Tidsramme: One day
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The Enzyme-linked immunosorbent assay (ELISA) to know blood selenoprotein P level
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One day
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Assesment of the severity of obstructive sleep apnea
Tidsramme: One day
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Full polysomnography
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One day
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Assessment of arrhythmias
Tidsramme: One day
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24-hour Holter ECG monitoring
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One day
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Assessment of arrhythmias and cardiac morphology
Tidsramme: One day
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Echocardiography
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One day
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Assesment of Blood Total Antioxidant Status (TAS)
Tidsramme: One day
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The Enzyme-linked immunosorbent assay (ELISA) to know Blood Total Antioxidant Status (TAS)
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One day
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Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studiestol: Paweł Gać, ASSOC PROF, Wroclaw Medical University
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- KB-39/2020
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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