Safety and Efficacy of ATG003 in Patients With Wet Age-Related Macular Degeneration (AMD)

October 26, 2010 updated by: CoMentis

A Phase II Randomized, Double-Masked, Study Comparing the Safety and Efficacy of ATG003 in Patients With Neovascular ("Wet") Age-Related Macular Degeneration (NV-AMD)

This is a Phase II randomized, double-masked study comparing the safety and efficacy of ATG003 (mecamylamine HCl) 1.0% and 0.3% ophthalmic solutions to placebo in patients with neovascular ("wet") age-related macular degeneration (NV-AMD).

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Terminated

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
343

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Brazil
      • Araraquara, Brazil
        • Hospital de Olhos de Araraquara
      • Belo Horizonte, Brazil
        • Centro Brasileiro de Ciências Visuais
      • Belo Horizonte, Brazil
        • Instituto da Visão
      • Goiânia, Brazil
        • Centro Brasileiro de Cirurgia dos Olhos
      • Porto Alegre, Brazil
        • Hospital de Clinicas de Porto Alegre
      • Rio de Janeiro, Brazil
        • Hospital Universitario Clementino Fraga Filho
      • São Paulo, Brazil
        • Clinica de Olhos Dr. Suel Abujamra
      • São Paulo, Brazil
        • Hospital das Clinicas Faculdade de Medicina da Universidade de São Paulo
      • São Paulo, Brazil
        • Hospital de Olhos de São Paulo
      • São Paulo, Brazil
        • Hospital São Paulo - Setor de Pesquisa Clínica
  • Czech Republic
      • Brno, Czech Republic
        • University Hospital Brno, Department of Ophthalmology
      • Hradec Kralove, Czech Republic
        • Eye Clinic University Hospital
      • Litomyšl, Czech Republic
        • Ophthalmology Nemocnice Litomysl
      • Olomouc, Czech Republic
        • University Hospital Olomouc, Department of Ophthalmology
      • Prague, Czech Republic
        • Faculty Hospital Kralovske Vinohrady, Dept. of Ophthalmology
      • Praha, Czech Republic
        • Cornea Lexum Praha
  • Mexico
      • CP, Mexico
        • Cif Biotec
      • CP, Mexico
        • Hospital Conde de Valenciana
      • Delegación Cuauhtémoc, Mexico
        • Fundación Hospital "Nuestra Sra de la Luz" I.A.P.
      • Mexico City, Mexico
        • Hospital General de Mexico
      • Mexico City, Mexico
        • Asociacion para Evitar la Ceguera
      • Monterrey, Mexico
        • Hospital San Jose Tec de Monterrey
  • Poland
      • Gdansk, Poland
        • Klinika Chorob Oczu
      • Katowice, Poland
        • Oddział Okulistyczny Okręgowy Szpital Kolejowy
      • Lodz, Poland
        • Klinika Okulistyczna
      • Poznań, Poland
        • Oddział Okulistyki, Samodzielny Publiczny Szpital Kliniczny Nr 1 Przemienienia Pańskiego AM w Poznaniu
      • Warsaw, Poland
        • Katedra i Klinika Okulistyki, Samodzielny Publiczny Kliniczny Szpital Okulistyczny
      • Wrocław, Poland
        • Katedra i Klinika Okulistyki, Akademia Medyczna we Wrocławiu
  • Russian Federation
      • Kazan, Russian Federation
        • Republican Ophthalmologic Hospital of MH of Republic of Tatarstan
      • Moscow, Russian Federation
        • IRTC "Eye Microsurgery" n. a. S.N. Fyodorov
      • Moscow, Russian Federation
        • Moscow Scientific Research Institute of Eye Diseases
      • Rostov-on Don, Russian Federation
        • CJSC "Inter Yuna"
      • St. Petersburg, Russian Federation
        • City Consultative Diagnostic Centre # 1 (St. Petersburg)
      • St. Petersburg, Russian Federation
        • IRTC "Eye Microsurgery" n. a. S.N. Fyodorov
      • St. Petersburg, Russian Federation
        • Military Medical Academy n.a. S.M.Kirov of Ministry of Defence
      • St. Petersburg, Russian Federation
        • St. Petersburg State Medical University n. a. Pavlov
  • Ukraine
      • Kyiv, Ukraine
        • Kyiv City Centre of Eye Vascular and Endocrine Diseases of Organ of Vision
      • Kyiv, Ukraine
        • Kyiv City Ophthalmologic Hospital "Eye Microsurgery Centre"
      • Kyiv, Ukraine
        • Kyiv City Ophthalmologic Hospital
      • Odessa, Ukraine
        • V.P. Filatov Institute of Eye Diseases and Tissue Pathology of AMS of Ukraine
      • Odessa, Ukraine
        • Zaporizhzhya Center of Vision Rehabilitation
      • Simferopol, Ukraine
        • S.I. Georgiyevsky Crimean State Medical University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

50 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Placebo Comparator: Placebo
Drug: Placebo
Active Comparator: 1% mecamylamine
Drug: Mecamylamine
Active Comparator: 0.3% mecamylamine
Drug: Mecamylamine

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
Proportion of Subjects Losing Fewer Than 15 ETDRS Letters of Visual Acuity at 48 Weeks Compared to Baseline.
Time Frame: Baseline to Week 48
Baseline to Week 48

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
CoMentis

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Study Director: Carl Grove, CoMentis

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
March 1, 2007

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
June 1, 2009

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
September 1, 2009

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
December 19, 2006

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 20, 2006

First Posted (Estimate)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
December 21, 2006

Study Record Updates

Last Update Posted (Estimate)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
November 23, 2010

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
October 26, 2010

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
October 1, 2010

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • ATG003-201

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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