Cognitive Rehabilitation With C8 Sciences

March 5, 2018 updated by: Joon-Ho Shin, National Rehabilitation Center, Seoul, Korea

Cognitive Rehabilitation for Participants With Stroke or Brain Injury Using C8 Sciences

C8 sciences program is a cognitive training program mainly developed for the students, and the effectiveness is well established. The aim of this trial is to assess clinical efficacy of the program for cognitive rehabilitation of the patients with stroke or brain injury.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
31

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Participants with stroke or brain injury
  • Cognitive deficits

Exclusion Criteria:

  • Uncontrolled medical comorbidities
  • Not able to perform outcome measurements
  • Aphasia, which hamper communication
  • Pre-diagnosed psychological or other neurological disease not relevant to stroke or brain injury

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: C8 sciences
cognitive rehabilitation with C8 sciences
Other: Computerized cognitive training program
1000 minutes of computerized cognitive rehabilitation with C8 sciences program
Active Comparator: Conventional cognitive rehabilitation
cognitive rehabilitation with conventional methods
Other: Conventional cognitive rehabilitation
Same amount of conventional cognitive rehabilitation

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
Change from baseline Cambridge Neuropsychological Test Automated Battery(CANTAB) Spatial working memory at 34 th intervention
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline
Change from baseline CANTAB Rapid Visual information Processing at 34 th intervention
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
CANTAB Spatial working memory
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Rapid Visual information Processing
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Motor control task
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Paired Associated Learning
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB reaction time
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Attention Switching Task
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Stoking of Cambridge
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Emotion Recognition Task
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
CANTAB Stop Signal Task
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
Geriatric depression scale
Time Frame: Baseline, 34th day from baseline
Older participants
Baseline, 34th day from baseline
Beck depression index
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline
Korean Mini-Mental State Examination (K-MMSE)
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline
Korean activities of daily living (K-ADL)
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
Korean instrumental activities of daily living (K-IADL)
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
clinical dementia rating scale (CDR)
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline
Stroke impact scale
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline
Subjective memory complaint questionnaire
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
NIH toolbox
Time Frame: Baseline, 17th day from baseline, 34th day from baseline, 64th day from baseline
Baseline, 17th day from baseline, 34th day from baseline, 64th day from baseline
Autobiographical memory
Time Frame: Baseline, 34th day from baseline
Baseline, 34th day from baseline
Trail making test (A/B)
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline
Trail making test - Black and White
Time Frame: Baseline, 34th day from baseline, 64th day from baseline
Baseline, 34th day from baseline, 64th day from baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
National Rehabilitation Center, Seoul, Korea

Collaborators

Collaborators

An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.
Hanyang University
National IT Industry Promotion Agency, Republic of Korea

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
December 1, 2014

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
October 27, 2017

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
October 27, 2017

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
February 23, 2015

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
March 4, 2015

First Posted (Estimate)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
March 10, 2015

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
March 6, 2018

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
March 5, 2018

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
March 1, 2018

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • NRC-2013-04-036

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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