Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor

August 3, 2021 updated by: Children's Cancer Hospital Egypt 57357

Impact of Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor

Medulloblastoma is a rapidly-growing tumor of the cerebellum, this area controls balance, posture and sophisticated motor functions like finer hand movements, speech, and swallowing. It has been reported that those children fall frequently so the purpose of this study is to investigate the effectiveness of balance and coordination training in these Children.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

The effects of physical exercise training interventions for childhood cancer participants are not yet convincing due to small numbers of participants and insufficient study methodology. More and high-quality evidence is needed in order to be able to draft exercise and physical activity guidelines for this population. Despite the positive results of exercise interventions in adult cancer patients, the evidence for benefits in childhood cancer patients is limited.

There are Two Main objectives:

  1. To investigate the effectiveness of Pilates core stability exercises program. 2. To investigate the effectiveness of Humac balance and tilt system.

Secondary Objectives:

  1. The effectiveness of coordination training in children with posterior fossa tumors.
  2. The comparison between balance and coordination training and which of both trainings has more effect.

This study will take place in a pediatric oncology setting, Children's Cancer Hospital Egypt(CCHE), in outpatient setting. Patients will be evaluated for their balance and coordination at initial presentation, during treatment, and during follow-up after end of treatment at CCHE. Also patients will receive balance and coordination training, before each chemotherapy cycle-maximum one week- given the patient is in good state.

Sixty children with posterior fossa tumors of both sexes will participate in this study. They will be selected from CCHE. They will be randomly assigned into 3 groups of equal number.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
60

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt, 11441
        • Children's Cancer Hospital Egypt 57357

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

5 years to 12 years (CHILD)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  1. Children with posterior fossa tumors during follow up.
  2. Children between 5-12 years old.
  3. Time elapsed since the start of treatment more than 4 months in order to be in maintenance phase.
  4. They can understand verbal command.
  5. Children with no visual, auditory or perceptual disorders.
  6. Children are already treated surgically.

Exclusion Criteria:

  • Children who have one or more of the following criteria will be excluded from the study:

    1. Children with a genetic disorder or mental retardation.
    2. Children with a chronic lung disease.
    3. Sever cardiomyopathy (ejection fraction <40%, ischemia and angina pectoris at rest).
    4. Children with a neuromuscular disease not related to tumor.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
ACTIVE_COMPARATOR: Control Group/Pilates Core Stability Exercises program Group

Twenty patients will receive Pilates core stability exercises program ONLY. Total Period: 12 Weeks

Stages: Three stages:

  • Stage I: Warm-up: consists of four Pilates motions:

    1. Breathing:
    2. Rolling back:
    3. Coccyx-curl:
    4. Hundred breathing:

  • Stage II: Work-out: consists of twelve Pilates motions:

    1. Single leg stretch:
    2. Straight leg raise:
    3. Basic bridge:
    4. Bridging variation:
    5. Quadruped:
    6. Clap with seal motion
    7. Mermaid twist:
    8. Swimming:
    9. Double leg stretch:
    10. Shoulder bridge:
    11. Swan dive:
    12. Leg full front:

  • Stage III: Cool-down: consists of three Pilates motions:

    1. Rest position:
    2. Cat with arm/leg extension:
    3. Breathing:
Behavioral: Pilates Core Stability Exercises program

Twenty patients will receive Pilates core stability exercises program ONLY. Total Period: 12 Weeks

Stages: Three stages:

  • Stage I: Warm-up: consists of four Pilates motions:

    1. Breathing:
    2. Rolling back:
    3. Coccyx-curl:
    4. Hundred breathing:

  • Stage II: Work-out: consists of twelve Pilates motions:

    1. Single leg stretch:
    2. Straight leg raise:
    3. Basic bridge:
    4. Bridging variation:
    5. Quadruped:
    6. Clap with seal motion
    7. Mermaid twist:
    8. Swimming:
    9. Double leg stretch:
    10. Shoulder bridge:
    11. Swan dive:
    12. Leg full front:

  • Stage III: Cool-down: consists of three Pilates motions:

    1. Rest position:
    2. Cat with arm/leg extension:
    3. Breathing:
EXPERIMENTAL: Balance Group
Twenty patients will receive the same selected Pilates core stability exercises program given to control group in addition to Balance Program
Behavioral: Pilates Core Stability Exercises program

Twenty patients will receive Pilates core stability exercises program ONLY. Total Period: 12 Weeks

Stages: Three stages:

  • Stage I: Warm-up: consists of four Pilates motions:

    1. Breathing:
    2. Rolling back:
    3. Coccyx-curl:
    4. Hundred breathing:

  • Stage II: Work-out: consists of twelve Pilates motions:

    1. Single leg stretch:
    2. Straight leg raise:
    3. Basic bridge:
    4. Bridging variation:
    5. Quadruped:
    6. Clap with seal motion
    7. Mermaid twist:
    8. Swimming:
    9. Double leg stretch:
    10. Shoulder bridge:
    11. Swan dive:
    12. Leg full front:

  • Stage III: Cool-down: consists of three Pilates motions:

    1. Rest position:
    2. Cat with arm/leg extension:
    3. Breathing:
Behavioral: Balance Program
Total Period: 12 Weeks. The designed HUMAC program will work on the modified clinical test of sensory integration of balance (mCTSIB) with eyes open and with eyes closed, the center of pressure (COP) and the limit of stability test (LOS).
Other Names:
  • HUMAC program
EXPERIMENTAL: Coordination Group
Twenty patients will receive the same selected Pilates core stability exercises program given to control group in addition to Coordination Exercises.
Behavioral: Pilates Core Stability Exercises program

Twenty patients will receive Pilates core stability exercises program ONLY. Total Period: 12 Weeks

Stages: Three stages:

  • Stage I: Warm-up: consists of four Pilates motions:

    1. Breathing:
    2. Rolling back:
    3. Coccyx-curl:
    4. Hundred breathing:

  • Stage II: Work-out: consists of twelve Pilates motions:

    1. Single leg stretch:
    2. Straight leg raise:
    3. Basic bridge:
    4. Bridging variation:
    5. Quadruped:
    6. Clap with seal motion
    7. Mermaid twist:
    8. Swimming:
    9. Double leg stretch:
    10. Shoulder bridge:
    11. Swan dive:
    12. Leg full front:

  • Stage III: Cool-down: consists of three Pilates motions:

    1. Rest position:
    2. Cat with arm/leg extension:
    3. Breathing:
Behavioral: Coordination

Total Period: 12 Weeks. Coordination will be assessed using BOT2, Bilateral coordination (Sub test No.4) composed of 7 items and Upper-Limb coordination (Sub test No.7) composed of 7 items too.

The raw scores are recorded first then it is converted into point scores, then subtest total point score is obtained by adding point scores.

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Change Balance
Time Frame: at week 12
For assessment of the three groups, HUMAC balance and tilt system will be used to assess both Static and dynamic balance.
at week 12

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Change Coordination
Time Frame: at week 12

The Bruininks-Oseretsky Test of Motor Proficiency - Second Edition

- The minimum and maximum values: Coordination will be assessed using BOT2, Bilateral coordination (Sub test No.4) composed of 7 items and Upper-Limb coordination (Sub test No.7) composed of 7 items too.

The raw scores are recorded first then it is converted into point scores, then subtest total point score is obtained by adding point scores.

Bilateral Coordination: Total Point Score Subtest (min=Zero, max=24). Upper-Limb Coordination: Total Point Score Subtest (min=Zero, max=39).

- Higher scores mean a better outcome.
at week 12

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Children's Cancer Hospital Egypt 57357

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Principal Investigator: Mahmoud Usama Mahmoud Ahmed, MSc, Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
August 6, 2020

Primary Completion (ACTUAL)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
April 30, 2021

Study Completion (ACTUAL)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
April 30, 2021

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
August 24, 2020

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 24, 2020

First Posted (ACTUAL)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
August 27, 2020

Study Record Updates

Last Update Posted (ACTUAL)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
August 4, 2021

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 3, 2021

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
August 1, 2021

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • CCHE-BT003

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Medulloblastoma, Childhood

Clinical Trials on Pilates Core Stability Exercises program

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Cookie Settings

We use cookies to ensure that we give you the best experience on our website. For more details carefully read our Privacy and Cookies Policy. ...>>>You can change your preferences or withdraw your consent at any time by deleting the cookies from your website or computer as described in the policy. Please accept it and choose your preferences by ticking the corresponding boxes in the "Manage Settings" section below. Please carefully read our Terms of Service before you proceed with using any part of this website.
«Manage Settings