German Cardiac Arrest Registry (G-CAR)

February 10, 2026 updated by: Leipzig Heart Science gGmbH
In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
400

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Contact Backup

Study Locations

  • Germany
      • Bad Friedrichshall, Germany, 74177
        • Recruiting
        • SLK-Kliniken Heilbronn - Klinikum am Plattenwald
        • Contact:
          • Thomas Dengler, MD, Prof. Dr.
      • Berlin, Germany, 12203
        • Recruiting
        • Charité Universitätsmedizin Berlin - Deutsches Herzzentrum Berlin
        • Contact:
          • Wulf Knie, MD
      • Bonn, Germany
        • Recruiting
        • Universitätsklinikum Bonn
        • Contact:
          • Sebastian Zimmer, Prof. Dr.
        • Contact:
          • Philip R Goody, Dr.
      • Bremen, Germany, 28277
        • Recruiting
        • Bremer Institut für Herz- und Kreislaufforschung am Klinikum Links der Weser
        • Contact:
          • Harm Wienbergen, Prof.
      • Cologne, Germany, 50937
        • Recruiting
        • Herzzentrum der Universität zu Köln
        • Contact:
          • Roman Pflister, Prof.
      • Dresden, Germany, 01307
        • Active, not recruiting
        • Herzzentrum Dresden GmbH
      • Düsseldorf, Germany, 40225
        • Recruiting
        • Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie
        • Contact:
          • Malte Kelm, Prof.
        • Contact:
          • Ralf Westenfeld, PD Dr.
      • Essen, Germany, 45138
        • Recruiting
        • Elisabeth Krankenhaus Essen - Klinik für Akut- und Notfallmedizin
        • Contact:
          • Ingo Voigt, Dr.
      • Frankfurt, Germany, 65929
        • Recruiting
        • Klinikum Frankfurt Höchst
        • Contact:
          • Daniel Bock, Dr.
      • Halle, Germany, 06120
        • Recruiting
        • Universitatsklinikum Halle (Saale)
        • Contact:
          • Daniel Sedding, Prof. Dr.
        • Contact:
          • Jochen Dutzmann, Dr.
      • Hamburg, Germany, 20246
        • Recruiting
        • Universitäres Herz- und Gefäßzentrum Hamburg
        • Contact:
          • Christoph Sinning, PD Dr.
      • Hamburg, Germany
        • Recruiting
        • Asklepios Klinik St- Georg Hamburg
        • Contact:
          • Eike P Tigges, Dr.
      • Heilbronn, Germany, 74078
        • Recruiting
        • SLK-Kliniken Heilbronn - Klinikum am Gesundbrunnen
        • Contact:
          • Marcus Hennersdorf, MD, Prof. Dr.
      • Homburg, Germany
        • Recruiting
        • Universitätsklinikum des Saarlandes
        • Contact:
          • Andreas Link, Prof.
      • Leipzig, Germany, 04289
      • Ludwigshafen, Germany, 67063
        • Recruiting
        • Klinikum der Stadt Ludwigshafen gGmbh
        • Contact:
          • Uwe Zeymer, Prof.
      • Lübeck, Germany
        • Recruiting
        • Herzzentrum Lübeck
        • Contact:
          • Tobias Graf, Dr.
      • Mannheim, Germany, 68167
        • Recruiting
        • Universitätsklinikum Mannheim
        • Contact:
          • Ibrahim Akin, Prof. Dr. med.
      • München, Germany, 81377
        • Recruiting
        • Klinikum der Universität München
        • Contact:
          • Clemens Scherer, MD
      • Neustadt, Germany, 67434
        • Recruiting
        • Marienhaus Klinikum Hetzelstift
        • Contact:
          • Patrick Swojanowsky, Dr.
      • Singen, Germany, 78224
        • Not yet recruiting
        • Hegau-Bodensee-Klinikum Singen
        • Contact:
          • Stephan Richter, MD
      • Singen, Germany, 78224
        • Recruiting
        • Hegau-Bodensee Klinikum
        • Contact:
          • Stephan Richter, MD
      • Villingen-Schwenningen, Germany, 78052
        • Recruiting
        • Schwarzwald-Baar Klinikum VS
        • Contact:
          • Sebastian Ewen, MD
      • Wiesbaden, Germany
        • Active, not recruiting
        • Dr. Horst Schmidt Kliniken
    • State of Berlin
      • Berlin, State of Berlin, Germany, 13353
        • Active, not recruiting
        • CHARITE - Universitätsmedizin Berlin - Campus Virchow Klinikum

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

patients with out-of-hospital cardiac arrest with assumed cardiovacular cause

Description

Inclusion Criteria:

  • patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

Exclusion Criteria:

  • rejection of register participation by patient or legal representative

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
In hospital mortality
Time Frame: until discharge, an average of 2 weeks
until discharge, an average of 2 weeks

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Mortality
Time Frame: Day 30
Day 30
Mortality
Time Frame: Month 6
Month 6
Length of ICU stay
Time Frame: until discharge, an average of 2 weeks
until discharge, an average of 2 weeks
Length of hospital stay
Time Frame: until discharge, an average of 2 weeks
until discharge, an average of 2 weeks
European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)
Time Frame: Month 6
five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'
Month 6
Post Traumatic Stress Syndrome
Time Frame: Month 6
PTSS-14
Month 6
Reintegration
Time Frame: Month 6
Reintegration to Normal Living Index
Month 6
Hospital Anxiety and Depression Scale (HADS)
Time Frame: Month 6
score 0-21; higher value show more severe depression
Month 6
Mortality
Time Frame: Month 12
Month 12
European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)
Time Frame: Month 12
five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'
Month 12
Post Traumatic Stress Syndrome (PTSS-14)
Time Frame: Month 12
scor 14-98; higher value indicate more post traumatic stress
Month 12
Reintegration
Time Frame: Month 12
Reintegration to Normal Living Index
Month 12
Hospital Anxiety and Depression Scale (HADS)
Time Frame: Month 12
score 0-21; higher value indicate more severe depression
Month 12
Mini Montreal Cognitive Assessment (MoCA)
Time Frame: Month 6
score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction
Month 6
Mini Montreal Cognitive Assessment (MoCA)
Time Frame: Month 12
score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction
Month 12

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Leipzig Heart Science gGmbH

Collaborators

Collaborators

An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.
Charite University, Berlin, Germany
Klinikum Ludwigshafen
St. Antonius Hospital
University of Magdeburg
Universitätsklinikum Hamburg-Eppendorf
University Hospital of Cologne
Heart Center Leipzig - University Hospital
IHF GmbH - Institut für Herzinfarktforschung
Helios Health Institute GmbH

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Study Chair: Janine Pöss, Dr., Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
July 21, 2021

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 31, 2026

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
June 30, 2027

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
November 8, 2021

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
November 18, 2021

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
December 2, 2021

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
February 12, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 10, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • 2020-0396

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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