German Cardiac Arrest Registry (G-CAR)

March 6, 2024 updated by: Leipzig Heart Science gGmbH
In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

400

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Germany
      • Berlin, Germany, 13353
        • Recruiting
        • CHARITE - Universitätsmedizin Berlin - Campus Virchow Klinikum
        • Contact:
          • Bastian Maroski, Dr.
      • Bonn, Germany
        • Recruiting
        • Universitätsklinikum Bonn
        • Contact:
          • Sebastian Zimmer, Prof. Dr.
        • Contact:
          • Philip R Goody, Dr.
      • Bremen, Germany, 28277
        • Recruiting
        • Bremer Institut für Herz- und Kreislaufforschung am Klinikum Links der Weser
        • Contact:
          • Harm Wienbergen, Prof.
        • Contact:
          • Jelena Köster, Dr.
      • Dresden, Germany, 01307
        • Recruiting
        • Herzzentrum Dresden GmbH
        • Contact:
          • Julia Fischer
      • Düsseldorf, Germany, 40225
        • Recruiting
        • Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie
        • Contact:
          • Malte Kelm, Prof.
        • Contact:
          • Ralf Westenfeld, PD Dr.
      • Essen, Germany, 45138
        • Recruiting
        • Elisabeth Krankenhaus Essen - Klinik für Akut- und Notfallmedizin
        • Contact:
          • Ingo Voigt, Dr.
      • Frankfurt, Germany, 65929
        • Recruiting
        • Klinikum Frankfurt Höchst
        • Contact:
          • Daniel Bock, Dr.
      • Halle (Saale), Germany, 06120
        • Recruiting
        • Universitatsklinikum Halle (Saale)
        • Contact:
          • Daniel Sedding, Prof. Dr.
        • Contact:
          • Jochen Dutzmann, Dr.
      • Hamburg, Germany, 20246
        • Recruiting
        • Universitäres Herz- und Gefäßzentrum Hamburg
        • Contact:
          • Christoph Sinning, PD Dr.
      • Hamburg, Germany
        • Recruiting
        • Asklepios Klinik St- Georg Hamburg
        • Contact:
          • Eike P Tigges, Dr.
      • Homburg, Germany
        • Recruiting
        • Universitätsklinikum des Saarlandes
        • Contact:
          • Sebastian Ewen, PD Dr.
      • Köln, Germany, 50937
        • Recruiting
        • Herzzentrum der Universität zu Köln
        • Contact:
          • Christoph Adler, PD Dr.
      • Leipzig, Germany, 04289
      • Ludwigshafen, Germany, 67063
        • Recruiting
        • Klinikum der Stadt Ludwigshafen gGmbH
        • Contact:
          • Uwe Zeymer, Prof.
      • Lübeck, Germany
        • Recruiting
        • Herzzentrum Lübeck
        • Contact:
          • Tobias Graf, Dr.
        • Contact:
          • Georg Fürnau, PD Dr.
      • München, Germany, 81377
        • Recruiting
        • Klinikum der Universität München
        • Contact:
          • Martin Orban, Prof. Dr.
      • Neustadt, Germany, 67434
        • Recruiting
        • Marienhaus Klinikum Hetzelstift
        • Contact:
          • Patrick Swojanowsky, Dr.
      • Wiesbaden, Germany
        • Recruiting
        • Dr. Horst Schmidt Kliniken
        • Contact:
          • Markus Ferrari, Prof. Dr.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

patients with out-of-hospital cardiac arrest with assumed cardiovacular cause

Description

Inclusion Criteria:

  • patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

Exclusion Criteria:

  • rejection of register participation by patient or legal representative

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
In hospital mortality
Time Frame: until discharge, an average of 2 weeks
until discharge, an average of 2 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mortality
Time Frame: Day 30
Day 30
Mortality
Time Frame: Month 6
Month 6
Length of ICU stay
Time Frame: until discharge, an average of 2 weeks
until discharge, an average of 2 weeks
Length of hospital stay
Time Frame: until discharge, an average of 2 weeks
until discharge, an average of 2 weeks
European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)
Time Frame: Month 6
five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'
Month 6
Post Traumatic Stress Syndrome
Time Frame: Month 6
PTSS-14
Month 6
Reintegration
Time Frame: Month 6
Reintegration to Normal Living Index
Month 6
Hospital Anxiety and Depression Scale (HADS)
Time Frame: Month 6
score 0-21; higher value show more severe depression
Month 6
Mortality
Time Frame: Month 12
Month 12
European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)
Time Frame: Month 12
five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'
Month 12
Post Traumatic Stress Syndrome (PTSS-14)
Time Frame: Month 12
scor 14-98; higher value indicate more post traumatic stress
Month 12
Reintegration
Time Frame: Month 12
Reintegration to Normal Living Index
Month 12
Hospital Anxiety and Depression Scale (HADS)
Time Frame: Month 12
score 0-21; higher value indicate more severe depression
Month 12
Mini Montreal Cognitive Assessment (MoCA)
Time Frame: Month 6
score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction
Month 6
Mini Montreal Cognitive Assessment (MoCA)
Time Frame: Month 12
score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction
Month 12

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Leipzig Heart Science gGmbH

Collaborators

Charite University, Berlin, Germany
Klinikum Ludwigshafen
St. Antonius Hospital
University of Magdeburg
Universitätsklinikum Hamburg-Eppendorf
University Hospital of Cologne
Heart Center Leipzig - University Hospital
IHF GmbH - Institut für Herzinfarktforschung
Helios Health Institute GmbH

Investigators

  • Study Chair: Janine Pöss, Dr., Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 21, 2021

Primary Completion (Estimated)

December 31, 2024

Study Completion (Estimated)

June 30, 2025

Study Registration Dates

First Submitted

November 8, 2021

First Submitted That Met QC Criteria

November 18, 2021

First Posted (Actual)

December 2, 2021

Study Record Updates

Last Update Posted (Actual)

March 7, 2024

Last Update Submitted That Met QC Criteria

March 6, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2020-0396

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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