to Evaluate the Safety and the Pharmacokinetic and Pharmacodynamic Interactions Between JP-1366 and Clopidogrel, Aspirin, Atorvastatin and Apixaban

December 2, 2025 updated by: Onconic Therapeutics Inc.

A Phase 1 Clinical Trial to Evaluate the Safety and the Pharmacokinetic and Pharmacodynamic Interactions Between JP-1366 and Clopidogrel, Aspirin, Atorvastatin and Apixaban in Healthy Volunteers.

to Evaluate the Safety and the Pharmacokinetic and Pharmacodynamic Interactions between JP-1366 and Clopidogrel, Aspirin, Atorvastatin and Apixaban

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
96

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • South Korea
    • Gyeonggi-do
      • Seongnam-si, Gyeonggi-do, South Korea, 13496
        • Recruiting
        • CHA University Bundang Medical Center
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Healthy subject aged ≥ 19 years to < 65 years at the time of screening
  • Subjects who weigh ≥ 50 kg (or ≥ 45 kg in the case of females) with body mass index (BMI) of ≥ 18.0 kg/m2 and ≤ 30.0 kg/m2
  • Subjects who have voluntarily decided to participate after fully understanding the clinical trial based on the detailed explanation given, and have provided written informed consent before the screening procedure.

Exclusion Criteria:

  • Subject who has a clinically significant history of disease in the liver, kidneys, digestive system, respiratory system, musculoskeletal system, endocrine system, neuropsychiatric system, hematopoietic and oncological system, or cardiovascular system.
  • The Subject who has a clinically significant bleeding or a history of congenital or acquired bleeding disorders such as hemophilia
  • Subject who has a history of gastrointestinal disorders (e.g., Crohn's disease, ulcerative disease, etc.) or surgery (excluding appendectomy, hernia repair, endoscopic polypectomy, or hemorrhoidectomy, fissure, or fistula surgery) that may affect the absorption of the investigational product.
  • The subject who has a hereditary disorder (galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption etc.).
  • Screening laboratory test showing any of the following abnormal laboratory results
  • Subjects who are judged unsuitable to participate in the study in the opinion of the investigator

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Factorial Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Part 1
JP-1366 and clopidogrel
Drug: JP-1366 and clopidogrel
A randomized, open label, multiple-dosing, 6-sequence, 3-period, 3-treatment, crossover design
Experimental: Part 2
JP-1366 and aspirin
Drug: JP-1366 and aspirin
An open-label, multiple-dosing, fixed sequence, 3-period design
Experimental: Part 3
JP-1366 and atorvastatin
Drug: JP-1366 and atorvastatin
An open-label, multiple-dosing, fixed sequence, 3-period design Period 1: Atorvastatin
Experimental: Part 4
JP-1366 and apixaban
Drug: JP-1366 and apixaban
An open-label, multiple-dosing, fixed sequence, 3-period design

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
[Part 1] Change in P2Y12 Reaction Unit (PRU) from baseline on day 8
Time Frame: baseline on day 8
Change in P2Y12 Reaction Unit (PRU)
baseline on day 8
[Part 2] Emax of arachidonic acid-induced platelet aggregation
Time Frame: up to 48 hours post-dose on Day 1
Emax of arachidonic acid-induced platelet aggregation
up to 48 hours post-dose on Day 1
[Part 2] AUEC0-24 of arachidonic acid-induced platelet aggregation
Time Frame: up to 48 hours post-dose on Day 1
AUEC0-24 of arachidonic acid-induced platelet aggregation
up to 48 hours post-dose on Day 1
[Part 2] Cmax,ss of JP-1366
Time Frame: up to 24 hours post-dose on Day 5
Cmax,ss of JP-1366
up to 24 hours post-dose on Day 5
[Part 2] AUCτ,ss of JP-1366
Time Frame: up to 24 hours post-dose on Day 5
AUCτ,ss of JP-1366
up to 24 hours post-dose on Day 5
[Part 2] Cmax of Aspirin
Time Frame: up to 48 hours post-dose on Day 1
Cmax of Aspirin
up to 48 hours post-dose on Day 1
[Part 2] AUClast of Aspirin
Time Frame: up to 48 hours post-dose on Day 1
AUClast of Aspirin
up to 48 hours post-dose on Day 1
[Part 3] Cmax,ss of JP-1366
Time Frame: up to 24 hours post-dose on Day 5
Cmax,ss of JP-1366
up to 24 hours post-dose on Day 5
[Part 3] AUCτ,ss of JP-1366
Time Frame: up to 24 hours post-dose on Day 5
AUCτ,ss of JP-1366
up to 24 hours post-dose on Day 5
[Part 3] Cmax,ss of Atorvastatin
Time Frame: up to 24 hours post-dose on Day 5
Cmax,ss of Atorvastatin
up to 24 hours post-dose on Day 5
[Part 3] AUCτ,ss of Atorvastatin
Time Frame: up to 24 hours post-dose on Day 5
AUCτ,ss of Atorvastatin
up to 24 hours post-dose on Day 5
[Part 4] Emax of Anti-Factor Xa activity
Time Frame: up to 48 hours post-dose on Day 5
Emax of Anti-Factor Xa activity
up to 48 hours post-dose on Day 5
[Part 4] AUEC0-12 of Anti-Factor Xa activity
Time Frame: up to 48 hours post-dose on Day 5
AUEC0-12 of Anti-Factor Xa activity
up to 48 hours post-dose on Day 5
[Part 4] Cmax,ss of JP-1366
Time Frame: up to 24 hours post-dose on Day 5
Cmax,ss of JP-1366
up to 24 hours post-dose on Day 5
[Part 4] AUCτ,ss of JP-1366
Time Frame: up to 24 hours post-dose on Day 5
AUCτ,ss of JP-1366
up to 24 hours post-dose on Day 5
[Part 4] Cmax,ss of Apixaban
Time Frame: up to 12 hours post-dose on Day 5
Cmax,ss of Apixaban
up to 12 hours post-dose on Day 5
[Part 4] AUCτ,ss of Apixaban
Time Frame: up to 12 hours post-dose on Day 5
AUCτ,ss of Apixaban
up to 12 hours post-dose on Day 5

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Onconic Therapeutics Inc.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
November 17, 2025

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
March 30, 2026

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
March 30, 2026

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
November 17, 2025

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 2, 2025

First Posted (Estimated)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
December 4, 2025

Study Record Updates

Last Update Posted (Estimated)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
December 4, 2025

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 2, 2025

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • JP-1366-106

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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