Children in Pancreatic Surgery: Indications, Procedures and Outcomes (ChiPS)

December 18, 2025 updated by: Richard Hunger, Medizinische Hochschule Brandenburg Theodor Fontane

Children in Pancreatic Surgery

Pediatric patients differ in a variety of properties from adult populations, but comprehensive multicenter or population-based data is missing for pancreatic surgery. This study aimed to evaluate indications, complications, and mortality in pediatric pancreatic surgery.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

This retrospective observational population-based cohort study analzes the German Diagnostic-Related Group database and included all children with pancreatic procedures between 2010 and 2023. The primary outcomes are mortality rates, complication rates, and sex differences related to surgical indication and pancreatic procedure. Descriptive epidemiological and multivariable regression analyses are performed to identify risk factors of mortality and occurrence of perioperative complications.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
761

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All persons addmitted to a German hospital between 2010 and 2023. Population-based dataset.

Description

Inclusion Criteria:

  • stationary hospital admission
  • pancreatic surgical procedure

Exclusion Criteria:

  • unknown sex or age
  • admission for pancreas tranplantation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Chronic pancreatitis
Procedure: Pancreatoduodenectomy
Procedure codes: 5-524.1; 5-524.2; 5-524.3
Procedure: Total pancreatectomy
Procedure codes: 5-525.*
Procedure: Distal pancreatectomy
Procedure code: 5-524.0
Procedure: Anastomosis of the pancreatic duct
Procedure codes: 5-527.*
Procedure: Incision of the pancreas
Procedure codes: 5-520.*
Procedure: Internal drainage of the pancreas
Procedure codes: 5-523.*
Procedure: Local excision destruction pancreas
Procedure codes: 5-521.*
Procedure: Marsupialization of a pancreatic cyst
Procedure codes: 5-522.*
Procedure: Segmental pancreatic resection
Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Pancreatic tumor
Procedure: Pancreatoduodenectomy
Procedure codes: 5-524.1; 5-524.2; 5-524.3
Procedure: Total pancreatectomy
Procedure codes: 5-525.*
Procedure: Distal pancreatectomy
Procedure code: 5-524.0
Procedure: Anastomosis of the pancreatic duct
Procedure codes: 5-527.*
Procedure: Incision of the pancreas
Procedure codes: 5-520.*
Procedure: Internal drainage of the pancreas
Procedure codes: 5-523.*
Procedure: Local excision destruction pancreas
Procedure codes: 5-521.*
Procedure: Marsupialization of a pancreatic cyst
Procedure codes: 5-522.*
Procedure: Segmental pancreatic resection
Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Trauma
Procedure: Pancreatoduodenectomy
Procedure codes: 5-524.1; 5-524.2; 5-524.3
Procedure: Total pancreatectomy
Procedure codes: 5-525.*
Procedure: Distal pancreatectomy
Procedure code: 5-524.0
Procedure: Anastomosis of the pancreatic duct
Procedure codes: 5-527.*
Procedure: Incision of the pancreas
Procedure codes: 5-520.*
Procedure: Internal drainage of the pancreas
Procedure codes: 5-523.*
Procedure: Local excision destruction pancreas
Procedure codes: 5-521.*
Procedure: Marsupialization of a pancreatic cyst
Procedure codes: 5-522.*
Procedure: Segmental pancreatic resection
Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Extra-pancreatic neoplasm
Procedure: Pancreatoduodenectomy
Procedure codes: 5-524.1; 5-524.2; 5-524.3
Procedure: Total pancreatectomy
Procedure codes: 5-525.*
Procedure: Distal pancreatectomy
Procedure code: 5-524.0
Procedure: Anastomosis of the pancreatic duct
Procedure codes: 5-527.*
Procedure: Incision of the pancreas
Procedure codes: 5-520.*
Procedure: Internal drainage of the pancreas
Procedure codes: 5-523.*
Procedure: Local excision destruction pancreas
Procedure codes: 5-521.*
Procedure: Marsupialization of a pancreatic cyst
Procedure codes: 5-522.*
Procedure: Segmental pancreatic resection
Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Other diseases
Procedure: Pancreatoduodenectomy
Procedure codes: 5-524.1; 5-524.2; 5-524.3
Procedure: Total pancreatectomy
Procedure codes: 5-525.*
Procedure: Distal pancreatectomy
Procedure code: 5-524.0
Procedure: Anastomosis of the pancreatic duct
Procedure codes: 5-527.*
Procedure: Incision of the pancreas
Procedure codes: 5-520.*
Procedure: Internal drainage of the pancreas
Procedure codes: 5-523.*
Procedure: Local excision destruction pancreas
Procedure codes: 5-521.*
Procedure: Marsupialization of a pancreatic cyst
Procedure codes: 5-522.*
Procedure: Segmental pancreatic resection
Procedure codes: 5-524.0*; 5-524-x; 5-524.y

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Mortality rate
Time Frame: 30 days
Perioperative death
30 days

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Complication rates
Time Frame: 30 days
Perioperative surgical-related complication
30 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Medizinische Hochschule Brandenburg Theodor Fontane

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
January 1, 2010

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 31, 2023

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 31, 2023

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
December 5, 2025

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 5, 2025

First Posted (Estimated)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
December 18, 2025

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
December 24, 2025

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 18, 2025

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
October 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • ChiPS

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

The data is held and provided by the Federal Statistical Office of Germany and the statistical offices of the federal states. Due to data privacy regulations, data sharing is strictly prohibited by German law. Furthermore, the data was evaluated exclusively within the framework of controlled remote data analysis. This meant that we never had direct access to the raw data.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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