Children in Pancreatic Surgery: Indications, Procedures and Outcomes (ChiPS)

Children in Pancreatic Surgery

Pediatric patients differ in a variety of properties from adult populations, but comprehensive multicenter or population-based data is missing for pancreatic surgery. This study aimed to evaluate indications, complications, and mortality in pediatric pancreatic surgery.

Study Overview

• Status: Completed
• Conditions: Children; Pancreatic Surgery
• Intervention / Treatment: Procedure: Pancreatoduodenectomy; Procedure: Total pancreatectomy; Procedure: Distal pancreatectomy; Procedure: Anastomosis of the pancreatic duct; Procedure: Incision of the pancreas; Procedure: Internal drainage of the pancreas; Procedure: Local excision destruction pancreas; Procedure: Marsupialization of a pancreatic cyst; Procedure: Segmental pancreatic resection

Detailed Description

This retrospective observational population-based cohort study analzes the German Diagnostic-Related Group database and included all children with pancreatic procedures between 2010 and 2023. The primary outcomes are mortality rates, complication rates, and sex differences related to surgical indication and pancreatic procedure. Descriptive epidemiological and multivariable regression analyses are performed to identify risk factors of mortality and occurrence of perioperative complications.

• Study Type: Observational
• Enrollment (Actual): 761

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

All persons addmitted to a German hospital between 2010 and 2023. Population-based dataset.

Description

Inclusion Criteria:

• stationary hospital admission
• pancreatic surgical procedure

Exclusion Criteria:

• unknown sex or age
• admission for pancreas tranplantation

Study Plan

How is the study designed?

Number of groups / cohorts

5

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Chronic pancreatitis	Procedure: Pancreatoduodenectomy; Procedure codes: 5-524.1; 5-524.2; 5-524.3; Procedure: Total pancreatectomy; Procedure codes: 5-525.*; Procedure: Distal pancreatectomy; Procedure code: 5-524.0; Procedure: Anastomosis of the pancreatic duct; Procedure codes: 5-527.*; Procedure: Incision of the pancreas; Procedure codes: 5-520.*; Procedure: Internal drainage of the pancreas; Procedure codes: 5-523.*; Procedure: Local excision destruction pancreas; Procedure codes: 5-521.*; Procedure: Marsupialization of a pancreatic cyst; Procedure codes: 5-522.*; Procedure: Segmental pancreatic resection; Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Pancreatic tumor	Procedure: Pancreatoduodenectomy; Procedure codes: 5-524.1; 5-524.2; 5-524.3; Procedure: Total pancreatectomy; Procedure codes: 5-525.*; Procedure: Distal pancreatectomy; Procedure code: 5-524.0; Procedure: Anastomosis of the pancreatic duct; Procedure codes: 5-527.*; Procedure: Incision of the pancreas; Procedure codes: 5-520.*; Procedure: Internal drainage of the pancreas; Procedure codes: 5-523.*; Procedure: Local excision destruction pancreas; Procedure codes: 5-521.*; Procedure: Marsupialization of a pancreatic cyst; Procedure codes: 5-522.*; Procedure: Segmental pancreatic resection; Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Trauma	Procedure: Pancreatoduodenectomy; Procedure codes: 5-524.1; 5-524.2; 5-524.3; Procedure: Total pancreatectomy; Procedure codes: 5-525.*; Procedure: Distal pancreatectomy; Procedure code: 5-524.0; Procedure: Anastomosis of the pancreatic duct; Procedure codes: 5-527.*; Procedure: Incision of the pancreas; Procedure codes: 5-520.*; Procedure: Internal drainage of the pancreas; Procedure codes: 5-523.*; Procedure: Local excision destruction pancreas; Procedure codes: 5-521.*; Procedure: Marsupialization of a pancreatic cyst; Procedure codes: 5-522.*; Procedure: Segmental pancreatic resection; Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Extra-pancreatic neoplasm	Procedure: Pancreatoduodenectomy; Procedure codes: 5-524.1; 5-524.2; 5-524.3; Procedure: Total pancreatectomy; Procedure codes: 5-525.*; Procedure: Distal pancreatectomy; Procedure code: 5-524.0; Procedure: Anastomosis of the pancreatic duct; Procedure codes: 5-527.*; Procedure: Incision of the pancreas; Procedure codes: 5-520.*; Procedure: Internal drainage of the pancreas; Procedure codes: 5-523.*; Procedure: Local excision destruction pancreas; Procedure codes: 5-521.*; Procedure: Marsupialization of a pancreatic cyst; Procedure codes: 5-522.*; Procedure: Segmental pancreatic resection; Procedure codes: 5-524.0*; 5-524-x; 5-524.y
Other diseases	Procedure: Pancreatoduodenectomy; Procedure codes: 5-524.1; 5-524.2; 5-524.3; Procedure: Total pancreatectomy; Procedure codes: 5-525.*; Procedure: Distal pancreatectomy; Procedure code: 5-524.0; Procedure: Anastomosis of the pancreatic duct; Procedure codes: 5-527.*; Procedure: Incision of the pancreas; Procedure codes: 5-520.*; Procedure: Internal drainage of the pancreas; Procedure codes: 5-523.*; Procedure: Local excision destruction pancreas; Procedure codes: 5-521.*; Procedure: Marsupialization of a pancreatic cyst; Procedure codes: 5-522.*; Procedure: Segmental pancreatic resection; Procedure codes: 5-524.0*; 5-524-x; 5-524.y

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality rate	Perioperative death	30 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Complication rates	Perioperative surgical-related complication	30 days

Collaborators and Investigators

• Sponsor: Medizinische Hochschule Brandenburg Theodor Fontane

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2010
• Primary Completion (Actual): December 31, 2023
• Study Completion (Actual): December 31, 2023

Study Registration Dates

• First Submitted: December 5, 2025
• First Submitted That Met QC Criteria: December 5, 2025
• First Posted (Estimated): December 18, 2025

Study Record Updates

• Last Update Posted (Actual): December 24, 2025
• Last Update Submitted That Met QC Criteria: December 18, 2025
• Last Verified: October 1, 2025

More Information

Terms related to this study

• Keywords: Pancreatic surgery; Surgical outcomes; Chidren
• Additional Relevant MeSH Terms: Surgical Procedures, Operative; Digestive System Surgical Procedures; Pancreaticoduodenectomy
• Other Study ID Numbers: ChiPS

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The data is held and provided by the Federal Statistical Office of Germany and the statistical offices of the federal states. Due to data privacy regulations, data sharing is strictly prohibited by German law. Furthermore, the data was evaluated exclusively within the framework of controlled remote data analysis. This meant that we never had direct access to the raw data.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No