The Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients

June 23, 2005 updated by: Gilead Sciences

A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Condyloma Acuminatum in Patients With HIV Infection

To evaluate the safety and tolerance of topical cidofovir (HPMPC) therapy for condyloma acuminatum in patients with HIV infection. To investigate whether topical HPMPC therapy can induce regression of condyloma acuminatum in patients with HIV infection.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Four groups of 10 patients each receive topical HPMPC at 0.3 percent concentration for 5 or 10 days total or 1.0 percent concentration for 5 or 10 days total, followed by 2 weeks of rest. When six patients at a given dose and schedule have completed treatment and follow-up without significant toxicity, subsequent patients are entered at the next higher dose level. Patients are evaluated twice weekly during treatment and once weekly during the rest period. HPMPC may be extended for up to two additional courses in patients who experience no significant toxicity.

Study Type

Interventional

Enrollment

40

Phase

  • Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Berkeley, California, United States, 94705
        • East Bay AIDS Ctr
      • San Francisco, California, United States, 941430316
        • Univ California San Francisco
    • Colorado
      • Denver, Colorado, United States, 802044507
        • City and County of Denver / Dept of Health & Hosps
    • New York
      • Bronx, New York, United States, 10453
        • Bronx-Lebanon Hosp Ctr
      • Rochester, New York, United States, 14642
        • Univ of Rochester Med Ctr
    • Texas
      • Houston, Texas, United States, 77006
        • Houston Clinical Research Network
      • Houston, Texas, United States, 77027
        • Dr Brad Bowden
      • Nassau Bay, Texas, United States, 77058
        • Dr Stephen Tyring
    • Utah
      • Salt Lake City, Utah, United States, 84132
        • Univ of Utah School of Medicine
    • Washington
      • Seattle, Washington, United States, 98122
        • Univ of Washington / Viral Disease Clinic
      • Seattle, Washington, United States, 98144
        • Pacific Med Ctr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria

Concurrent Medication:

Allowed:

  • AZT, ddI, ddC, d4T, or 3TC.
  • Oral trimethoprim/sulfamethoxazole.
  • Aerosolized pentamidine.
  • Dapsone.
  • Fluconazole.
  • Rifabutin.
  • Clarithromycin.

Patients must have:

  • HIV seropositivity.
  • Mean CD4 count >= 100 cells/mm3.
  • External anogenital condyloma acuminatum confirmed by biopsy, present for less than 1 year. NOTE:
  • Warts on anal, urethral, or vaginal mucosa will not be studied.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

  • Active lesions of genital herpes, other skin wounds, or active inflammatory skin disorders in the same area as warts to be treated.
  • Active medical problems sufficient to hinder study compliance.

Concurrent Medication:

Excluded:

  • Podofilox or any podophyllum resin preparation.
  • Liquid nitrogen treatment.
  • Interferon alpha.
  • Trichloracetic acid.
  • Other treatments, topical or systemic, surgical or ablative, known to have anti-papilloma activity.
  • Other investigative drugs (except d4T or 3TC) unless approved by the sponsor.

Patients with the following prior conditions are excluded:

History of untreated syphilis or Bowenoid papulosis.

Prior Medication:

Excluded within 4 weeks prior to study entry:

  • Treatment for anogenital warts.
  • Immunomodulators (including interferons or systemic corticosteroids).
  • Lymphocyte replacement therapy.
  • Biologic response modifiers. Substance abuse.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Gilead Sciences

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • Douglas J, Corey L, Tyring S, Kriesel J, Bowden B, Crosby D, Berger T, Conant M, McGuire B, Jaffe HS. A phase I/II study of cidofovir topical gel for refractory condyloma acuminatum in patients with HIV infection. Conf Retroviruses Opportunistic Infect. 1997 Jan 22-26;4th:126 (abstract no 334)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted

November 2, 1999

First Submitted That Met QC Criteria

August 30, 2001

First Posted (Estimate)

August 31, 2001

Study Record Updates

Last Update Posted (Estimate)

June 24, 2005

Last Update Submitted That Met QC Criteria

June 23, 2005

Last Verified

August 1, 1997

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 219A
  • GS-93-302

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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