- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00037505
Major Depression and Inflammatory Risk Markers for Coronary Heart Disease
June 23, 2005 updated by: National Center for Research Resources (NCRR)
The overall purpose of this research is to examine whether depression influences immune system function.
Studies indicate that individuals who are depressed experience coronary heart disease at a higher rate than expected.
This study's goal is to begin identifying mechanisms that might be responsible for this process.
This research also examines whether behavioral processes (e.g.
smoking) or hormonal processes (e.g.
adrenaline release) are responsible for immune system differences between depressed and nondepressed people
Study Overview
Status
Completed
Conditions
Detailed Description
To qualify for participation, subjects are to be between the ages of 18-55, medically healthy and free of all medication three months prior to enrollment.
Half of them will be clinically depressed; the remaining one half will be healthy controls without a history of psychiatric illness.
All subjects who qualify for the study will attend two laboratory sessions.
During the first visit, participants will undergo a structured psychological interview, complete questionnaires about their mood, personality, and behavior, and have blood drawn to assess their immune system function.
During the second visit, participants will complete additional questionnaires about their mood, personality, and behavior.
The subjects will also participate in a mock job interview to look at their body's response to stress.
Before and after the interview, the subjects will have blood drawn and be asked to collect saliva samples to assess their immune system function.
In addition to the two laboratory visits, participants will be asked to collect additional information while going about their normal activities.
In order to accomplish this, they will be given a small hand held portable computer.
Four times each day for four days, the computer will signal them to collect a saliva sample.
This will be used later to measure hormone levels.
This study will explore changes in the immune system and metabolic system that might predispose depressed individuals to develop heart disease
Study Type
Observational
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Missouri
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St. Louis, Missouri, United States, 63130
- Washington University
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
15 years to 55 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
For eligibility, potential subjects will be 18-55 years of age, free of all medication during the past three months, and have no history of chronic illness involving the cardiovascular, endocrine, immune systems
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Defined Population
- Time Perspectives: Other
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Registration Dates
First Submitted
May 17, 2002
First Submitted That Met QC Criteria
May 17, 2002
First Posted (Estimate)
May 20, 2002
Study Record Updates
Last Update Posted (Estimate)
June 24, 2005
Last Update Submitted That Met QC Criteria
June 23, 2005
Last Verified
December 1, 2003
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NCRR-M01RR00036-0849
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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