- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00229814
Study of Brain Tumors (Tectal Tumors) Using Magnetic Resonance Imaging
Magnetic Resonance Spectroscopic Analysis of Pediatric Tectal Tumors: Insight Into Pathology and Behavior
Tectal plate gliomas are relatively rare tumors of childhood with a reported incidence of 10%. Their typical clinical presentation is symptoms and signs of hydrocephalus and are often incidentally diagnosed in the imaging work-up of children with hydrocephalus. Tectal tumors in children comprise a subcategory of brainstem tumors with unique clinical, imaging, and spectroscopic features. There is debate whether they truly represent brainstem tumors or whether they are a site of benign cellular overgrowth. The majority of these tumors are pathologically benign and show no or minimal growth. Not all tectal plate tumors, however, have this typically benign course. Some can manifest a more aggressive behavior. There have been reports in the past attempting to analyze the histology and behavior of these tumors. None of the prior series looking at these tumors have included Magnetic Resonance Spectroscopy (MRS) analysis.
It is interesting that according to where tumors occur in the brainstem usually indicates what their histology and behavior is. Although not absolute, we know that tumors can have a very poor prognosis versus an extremely good prognosis depending on their location in the brainstem. Yet there are always the cases that do not act in the typical fashion and this is where MRS can prove helpful.
This study is being done to look at a region of the brain, called the tectal plate, in children. This part of the brain can be involved by tumors. Because of the location of the tectal plate, it is usually very difficult and risky to get a biopsy (tissue sample) from this area. Magnetic Resonance Spectroscopy (MRS) is a non-invasive imaging technique that can look at the chemical make up of the brain. MRS may allow us to better understand the nature and behavior of these tumors. However, in order to understand disease in this area, we need to look at the normal chemical make up of the brain in children without tectal plate tumors. Healthy patients are being asked to participate as a normal volunteer. We anticipate having a total of 10 to 12 normal volunteers in the MRS study.
Study Overview
Status
Conditions
Study Type
Contacts and Locations
Study Locations
-
-
Georgia
-
Atlanta, Georgia, United States, 30342
- Children's Healthcare of Atlanta at Scottish Rite
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- patients who are already scheduled for a brain MRI at Children's Healthcare of Atlanta at Scottish Rite for reasons other than tectal plate glioma evaluation
Exclusion Criteria:
- patients with tectal plate glioma
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Retrospective
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Susan Palasis, M.D., Children's Diagnostic Imaging of Atlanta
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- Tectal Tumors MRS
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Tectal Plate Glioma
-
Pennington Biomedical Research CenterOhio State UniversityCompleted
-
Benha UniversityRecruitingGlandular Urethral Disassembly | Tubularized Incised Plate | Distal Hypospadius RepairEgypt
-
The Second Hospital of QinhuangdaoCompletedVolar Plate Injury, Thumb, Metacarpophalangeal JointChina
-
Mayo ClinicEnrolling by invitation
-
National Health Service, United KingdomUniversity of BradfordCompletedVolar Plate Injury of the Proximal Interphalangeal JointUnited Kingdom
-
Zimmer BiometNot yet recruitingMedian Sternotomy | Rigid Plate FixationUnited States
-
National Taiwan University HospitalCompletedSurgery | Metatarsalgia | Hammer Toe | Plantar Plate Tear | Lesser Metatarsophalangeal Joint Instability | Plantar Plate RepairTaiwan
-
Norfolk and Norwich University Hospitals NHS Foundation...DePuy International; Global Diagnostics UKCompletedDistal Radial Fractures Treated With a DVR-A Locking PlateUnited Kingdom
-
Universidad de La FronteraSOCIEDAD CHILENA DE ORTOPEDIA Y TRAUMATOLOGIAUnknownSurgery | Distal Radius Fracture | Wrist Fracture, | Pronator Quadratus | Volar PlateChile