- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00313092
Obstructive Sleep Apnea Syndrome in Glaucoma
October 1, 2015 updated by: Selim Orguel
Does Plasma Matrix-metalloproteinase Activity Predict Glaucomas in Patients With OSAS (Obstructive Sleep Apnea Syndrome) and Does the Level of Plasma Matrix-metalloproteinase Activity Decrease After One Month of nCPAP-treatment
The aim of the study is to determine if plasma matrix-metalloproteinase activity can predict glaucoma in patients with OSAS and if the level of plasma matrix-metalloproteinase activity will decrease after one month of nCPAP-treatment.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
Glaucoma is a leading cause of blindness world-wide.
Chronic primary open-angle glaucoma is the most common form among Caucasian patients.
The key feature of glaucoma is damage to the optic nerve head, which is not necessarily related to an increased intraocular pressure.
The prevalence of glaucoma among the patients with sleep apnoea was 7,2%: normal-tension glaucoma 2,9%, primary open-angle glaucoma 4,3%.
The prevalence of obstructive sleep apnoea syndrome (OSAS) is around 4-10% for men and 2-4% for women.
Matrix metalloproteinases (MMPs) substrates include essentially all extracellular matrix components as well as a wide array of molecules involved in intracellular adhesion, cell-matrix interaction, and cell signalling.
However, MMPs effects are not restricted to extracellular matrix degradation.
The prevalence of increased MMP in patients with OSAS and its predicting value for an additional glaucoma are not known.
Further, we do not know if treatment of OSAS with nasal continuous positive air pressure(nCPAP) can decrease the MMP activity.
With this study, we want to determine the prevalence of MMP activity and the prevalence of glaucoma in patients with OSAS.
Further, we want to investigate if a nCPAP treatment period of four weeks decreases the MMP activity.
Study Type
Observational
Enrollment (Actual)
60
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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BS
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Basel, BS, Switzerland, 4031
- University Hospital Basel, Eye Clinic
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 95 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients with sleep apnoe syndrom
Description
Inclusion Criteria:
- OSAS planned begin of a nCPAP treatment
Exclusion Criteria:
- Current malignancy
- Oral steroids
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Director: Selim Orgül, MD, University Eye Clinic Basel
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2005
Primary Completion (Actual)
September 1, 2005
Study Completion (Actual)
September 1, 2005
Study Registration Dates
First Submitted
April 10, 2006
First Submitted That Met QC Criteria
April 10, 2006
First Posted (Estimate)
April 11, 2006
Study Record Updates
Last Update Posted (Estimate)
October 2, 2015
Last Update Submitted That Met QC Criteria
October 1, 2015
Last Verified
October 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 045-LEJ-2004-002
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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