- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00433303
Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
During the past years there has been a conflict between different studies regarding the correlation between intercourse during pregnancy and early labor. Brustman et al showed that women that were at a high risk for early delivery and had intercourse and then an early labor had significantly increase uterine activity compared to women at low risk. Petridou et al showed that this risk is significantly higher at week 33 of gestation. However, the Cochrane Library summary leaves the question of correlation between intercourse and early labor unanswered. In Sayle et al's study showed no correlation between early delivery and intercourse. In 2004 Oguma described 3 polymorphisms in the Prostanoid receptor gene. These polymorphisms were correlated to increased activity of smooth muscles of bronchi in asthma. Since this gene is also expressed in the uterine muscles we wanted to determine whether there is a correlation between the three polymorphisms T-549C, C-441T, T-197C, G+1044A and early delivery due to intercourse.
- Brustman LS, Raptoulis M. Langer O, Anyaegbunam A & Merkatz IR. Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor. Obstet Gynecol 1989;73:166-168
- Petridou E, Salvnos H, Skalkidou A, Dessypris N, Moustaki M & Trichopoulos D. Are there common triggers of preterm deliveries. British J Obst Gynecol 2001;108:598-604)
- Kavanagh J, Kelly AJ & Thomas J. Sexual intercourse for cervical ripening and induction of labour. The Cochrane Database of Systematic Reviews 2001, Issuse 2.Art. No.:CD003093. DOI: 10.1002/14651858.CD003093
- Sayle AE, Savitz DA, Thorp JM, Hertz-Picciotto I & Wilcox AJ. Sexual activity during late pregnancy and risk of preterm delivery. Obstet Gynecol 2001;97:283-9)
- Bernal AL. Mechanisms of labour-biochemical aspects. BJOG 2003;110(Supp 20):39-45
- Oguma T, Palmer L, Birden E, Sonna LA, Asano K& Lilly CM. Role of prostanoid dp receptor variants in susceptibility to asthma. NEJM 2004;351:1752-63
Study Type
Contacts and Locations
Study Contact
- Name: Michael Schimmel, Prof.
- Phone Number: 972-2-6550689
- Email: schimmel@New.szmc.org.il
Study Locations
-
-
-
Jerusalem, Israel, 91031
- Shaare Zedek Medical Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Women who start delivery in weeks 23-35 of pregnancy 12 hours after intercourese.
- Women who come for delivery after week 31 and have not had intercourse during the previous month.
- Women at term who have been sexually active during their pregnancy.
Exclusion Criteria:
- Any other women who come in for delivery.
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Michael Schimmel, Prof., Neonatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel
Publications and helpful links
Study record dates
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Intercourse-Prostanoid DP
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Labor Onset
-
University Hospital, GenevaQIAGEN Gaithersburg, Inc; Hologic, Inc.; Pregnolia ACCompletedLabor Onset | Labor, Induced | Labor, Obstetric | Predictive ModelSwitzerland
-
Oregon Health and Science UniversityMedical Research Foundation, Oregon; Bloomlife Technologies; OHSU School of NursingUnknownLabor Onset | Cervical Dilation | Labor Onset BiomarkersUnited States
-
University of TennesseeRecruitingLabor Onset and Length Abnormalities | Labor Long | Prolonged Labor | Labor; PoorUnited States
-
Centre Hospitalier Universitaire de NīmesTerminatedObstetric Labor, Premature | Obstetric Labor | Labor OnsetFrance
-
Hospital General Universitario Gregorio MarañonUnknownLabor Pain | Labor Onset | Parturition | Natural Childbirth | Humanizing Deliver | First Labor StageSpain
-
mohamed abosenaAin Shams UniversityCompletedLabor Onset and Length AbnormalitiesEgypt
-
Ain Shams UniversityCompletedLabor Onset and Length AbnormalitiesEgypt
-
Dilafor ABCompletedLabor Onset and Length AbnormalitiesFinland, Sweden
-
University of California, San FranciscoWithdrawnLabor Onset and Length AbnormalitiesUnited States
-
Centro Hospitalar Lisboa NorteRecruitingLabor; Forced or Induced, Affecting Fetus or Newborn | Labor Onset and Length AbnormalitiesPortugal
Clinical Trials on Correlation between early delivery and coital activity
-
Cairo UniversityCompletedCerebral Palsy | Parent-Child RelationsEgypt
-
Centre Hospitalier Universitaire, AmiensTerminatedGlioblastoma | Molecular DiseaseFrance
-
Centre Hospitalier Universitaire de BesanconUnknownObesity, ChildhoodFrance
-
Cairo UniversityCompletedPerfusion Index Predicts Post-spinal HypotensionEgypt
-
Hospices Civils de LyonRecruitingSubarachnoid HemorrhageFrance
-
Australian and New Zealand Intensive Care Research...National Health and Medical Research Council, Australia; Intensive Care National... and other collaboratorsCompletedCritically Ill, Mechanically VentilatedAustralia, New Zealand, United Kingdom, Ireland, Germany
-
Australian and New Zealand Intensive Care Research...National Health and Medical Research Council, Australia; Medical Research Institute... and other collaboratorsEnrolling by invitationCritically Ill | Mechanical Ventilation | Long Term OutcomeAustralia
-
Poitiers University HospitalCompletedPostnatal DepressionFrance
-
University of AarhusNovo Nordisk A/S; Region MidtJylland DenmarkCompletedHealth Behavior | Mother-Child RelationsDenmark
-
Cukurova UniversityActive, not recruitingObesity, MorbidTurkey