- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00442884
Effect of Acute Psychological Stress on Glucose Concentrations in Patients With Type 2 Diabetes
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Patients with type 2 diabetes often complain about changing blood glucose levels in times of emotional or mental stress, most subject's self-reporting higher blood glucose measurements in stressful conditions. To daily distress in diabetes additional emotional or mental stress can add a further momentum to destabilize glucose levels due to the adrenocortical response with enhancing insulin resistance and decreasing the endogenous insulin secretion. Another physiological link between stress and diabetes might be a higher sensitivity of the hypothalamo-pituitary-adrenal axis, leading to antagonizing effects on insulin actions. A study in type 2 diabetes demonstrated that stressors can destabilize blood glucose levels. Stress levels in diabetes have been shown to have a relationship to diabetic complications. Previous studies of psychological stress in type 1 diabetes have shown no effect of elevated catecholamine levels after short-lived psychological stimuli on glucose levels, but a significantly delayed decrease of glucose concentrations after an acute psychological stress in the postprandial state in association with elevated cortisol levels, showing no change of glucose concentration in the fasting state. This was in contrast to previous data in healthy subjects, showing that low glucose levels before a psychological stress prevented the stress-induced activation of the hypothalamus pituitary adrenal axis, but postprandial higher blood glucose levels induced a large cortisol response. These findings of a different cortisol responses in the fasting or fed status in healthy or absolute insulin deficient subjects could also be relevant for glucose metabolism in subjects with type 2 diabetes.
The effect of an acute psychological stress on glucose concentration may critically depend on whether stress is applied in the fasting or fed state. A different metabolic response to stress depending on food intake could explain different findings in other clinical trials and contribute to understanding glucose responses to stress. The aim of our study was thus to test whether the effect of acute psychological stress on glucose concentrations is different in the fasting compared to the fed state in type 2 diabetes.
Study Type
Enrollment
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Zurich, Switzerland, 8091
- University Hospital of Zurich, Division of Endocrinology and Diabetes
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- type 2 diabetes
- oral antidiabetic treatment and/or long acting insulin overnight
Exclusion Criteria:
- full insulin regimen
- pregnancy or breast-feeding
- instable coronary heart disease
- poor visibility
- proliferative diabetic retinopathy
- uncontrolled arterial hypertension
Study Plan
How is the study designed?
Design Details
- Primary Purpose: ECT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
change of glucose measurements after stress test in the fasting and fed state
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Peter Wiesli, MD, University of Zurich
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- EK-1261
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Type 2 Diabetes
-
Antonio Di MauroCompletedType-2 DiabetesItaly
-
DiaMedica Therapeutics IncCompletedDiabetes Type 2Netherlands
-
RenJi HospitalUnknownType 2 Diabetes.China
-
University of Erlangen-Nürnberg Medical SchoolCompletedType 2-diabetesGermany
-
Chengdu Brilliant Pharmaceutical Co., Ltd.Not yet recruitingType 2 Diabetes Mellitus
-
Nanjing First Hospital, Nanjing Medical UniversityRecruitingType 2 Diabetes MellitusChina
-
Xiangya Hospital of Central South UniversityRecruitingType 2 Diabetes MellitusChina
-
University of Alabama at BirminghamCompletedType 2 Diabetes MellitusUnited States
-
Imperial College LondonAstraZeneca; Huma; North West London Collaboration of CCGs (NWL CCGs); Imperial...CompletedType 2 Diabetes MellitusUnited Kingdom
-
Universiti Sains MalaysiaCompleted
Clinical Trials on Trier Social Stress Test (TSST)
-
Psychiatric University Hospital, ZurichRecruitingStress, Psychological | Stress, Physiological | Psychiatric Disorder | Stress ReactionSwitzerland
-
Massachusetts Institute of TechnologyMassachusetts General HospitalNot yet recruiting
-
Columbia UniversityNational Institute of Mental Health (NIMH); Massachusetts General Hospital; Dartmouth... and other collaboratorsSuspended
-
University of MiamiCompleted
-
University Hospital, MontpellierTerminated
-
Medical University of South CarolinaCompletedTrauma | Posttraumatic Stress DisorderUnited States
-
University of WashingtonNational Institute of Environmental Health Sciences (NIEHS)UnknownInflammation | Blood Pressure | CatecholaminesUnited States
-
Charite University, Berlin, GermanyRecruiting
-
University of California, Los AngelesMayo Clinic; Columbia University; University of Southern California; University... and other collaboratorsRecruitingInflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression (TIGER)Depression in AdolescenceUnited States
-
Baylor College of MedicineUniversity of Pittsburgh; Brown UniversityRecruitingObsessive-Compulsive Disorder | OCDUnited States