Aortic Dimensions in Turner Syndrome

Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Study Overview

• Status: Unknown
• Conditions: Turner Syndrome

• Study Type: Observational
• Enrollment (Actual): 102

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

Recrutted from hospital clinics and through the patient organisation

Description

Inclusion Criteria:

• Turner syndrome
• Age 18-70 years

Exclusion Criteria:

• Extreme adipositas
• Contraindications to a MRI scan
• Malignant disease

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
1; women with Turner syndrome
2.; Control women

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Aortic diameter at 3 well-defined levels measured by MRI and ECHO	2-yearly for 6 years

Secondary Outcome Measures

Outcome Measure	Time Frame
24hour ambulatory blood pressure	24h 2-yearly for 6 years

Collaborators and Investigators

• Sponsor: University of Aarhus

Publications and helpful links

General Publications

• Trolle C, Mortensen KH, Bjerre M, Hougaard DM, Cohen A, Andersen NH, Gravholt CH. Osteoprotegerin in Turner syndrome - relationship to aortic diameter. Clin Endocrinol (Oxf). 2015 Mar;82(3):397-403. doi: 10.1111/cen.12522. Epub 2014 Jul 2.
• Trolle C, Mortensen KH, Pedersen LN, Berglund A, Jensen HK, Andersen NH, Gravholt CH. Long QT interval in Turner syndrome--a high prevalence of LQTS gene mutations. PLoS One. 2013 Jul 25;8(7):e69614. doi: 10.1371/journal.pone.0069614. Print 2013.

Study record dates

Study Major Dates

• Study Start: August 1, 2003
• Primary Completion (Anticipated): June 1, 2012
• Study Completion (Anticipated): June 1, 2012

Study Registration Dates

• First Submitted: February 19, 2008
• First Submitted That Met QC Criteria: February 27, 2008
• First Posted (Estimate): February 28, 2008

Study Record Updates

• Last Update Posted (Estimate): February 28, 2008
• Last Update Submitted That Met QC Criteria: February 27, 2008
• Last Verified: February 1, 2008

More Information

Terms related to this study

• Keywords: blood pressure; Turner syndrome; aortic dimensions; aortic dilatation; aortic rupture
• Additional Relevant MeSH Terms: Pathologic Processes; Heart Diseases; Cardiovascular Diseases; Endocrine System Diseases; Disease; Gonadal Disorders; Disorders of Sex Development; Urogenital Abnormalities; Congenital Abnormalities; Genetic Diseases, Inborn; Heart Defects, Congenital; Cardiovascular Abnormalities; Chromosome Disorders; Sex Chromosome Disorders; Sex Chromosome Disorders of Sex Development; Syndrome; Turner Syndrome; Gonadal Dysgenesis
• Other Study ID Numbers: 20010248