Sleep Loss and Glucose Metabolism in People With Family History of Type 2 Diabetes.

Sleep, Energy Metabolism and Diabetes Risk.

The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that the carbohydrate metabolism of people who have a history of type 2 diabetes in their family will be different after they have slept short hours for 10 days in comparison to when they have slept longer hours for 10 days.

Study Overview

• Status: Completed
• Conditions: Sleep; Insulin Resistance; Type 2 Diabetes; Sleep Deprivation
• Intervention / Treatment: Other: 5-hour bedtime; Other: 8.5-hour bedtimes

Detailed Description

Study participants will complete two 10-day inpatient stays in the sleep laboratory of the University of Chicago Clinical Resource Center scheduled at least 4 weeks apart. Bedtime duration will be set at 5 hours per night during one of these stays and 8.5 hours per night during the other. No daytime naps will be allowed. Study participants will be served regular daily meals including breakfast, lunch, dinner, and a bedtime snack. On weekdays all participants will engage in simulated "office work" while in the sleep laboratory. During the rest of the time participants will maintain their usual indoor and outdoor activities as much as possible within the limits of the University of Chicago campus. During the last two days of each inpatient stay in the laboratory, participants will undergo two different tests. The first test will determine how much insulin does their body produce in response to an intravenous glucose infusion lasting several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

• Study Type: Interventional
• Enrollment (Actual): 11
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Illinois
    • Chicago, Illinois, United States, 60637
      • University of Chicago

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• regular sleep habits
• BMI 20 to 27 kg/m2
• at least one parent, sibling or grandparent with type 2 diabetes
• no regular exercise habits

Exclusion Criteria:

• active smoker
• night or shift work
• have highly variable sleep habits
• have a hormonal disorder
• have a sleep disorder
• have an active medical problem
• women only: use of birth control pills
• women only: irregular menstrual periods or pregnancy
• use of medications/compounds that can disrupt sleep

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 8.5-hour bedtime	Other: 8.5-hour bedtimes; 10 days with sleep allowed only during a 8.5-hour period at night
Experimental: 5-hour bedtime	Other: 5-hour bedtime; 10 days with sleep restricted only to a 5-hour bedtime period at night

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Total body insulin sensitivity	at the end of each bedtime intervention

Secondary Outcome Measures

Outcome Measure	Time Frame
First and second phase insulin secretion	at the end of each bedtime intervention
Endogenous glucose production	at the end of each bedtime intervention
Glycerol turnover and free fatty acid concentrations	at the end of each bedtime intervention

Collaborators and Investigators

• Sponsor: University of Chicago
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
• Investigators: Principal Investigator: Plamen D Penev, MD, PhD, University of Chicago

Study record dates

Study Major Dates

• Study Start: July 1, 2008
• Primary Completion (Actual): March 1, 2012
• Study Completion (Actual): March 1, 2012

Study Registration Dates

• First Submitted: July 21, 2008
• First Submitted That Met QC Criteria: July 21, 2008
• First Posted (Estimate): July 23, 2008

Study Record Updates

• Last Update Posted (Estimate): September 5, 2013
• Last Update Submitted That Met QC Criteria: September 4, 2013
• Last Verified: September 1, 2013

More Information

Terms related to this study

• Keywords: insulin secretion; free fatty acids; insulin action; lipid turnover; short sleep duration; glucose clamp technique
• Additional Relevant MeSH Terms: Mental Disorders; Glucose Metabolism Disorders; Metabolic Diseases; Nervous System Diseases; Dyssomnias; Sleep Wake Disorders; Neurologic Manifestations; Endocrine System Diseases; Hyperinsulinism; Diabetes Mellitus; Diabetes Mellitus, Type 2; Insulin Resistance; Sleep Deprivation
• Other Study ID Numbers: 16079A-S3; R01HL089637 (U.S. NIH Grant/Contract)