Sleep Loss and Energy Metabolism in People With Family History of Type 2 Diabetes.

Sleep, Energy Metabolism and Diabetes Risk.

The use of energy from food changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the amount of energy that people who have a relative with type 2 diabetes (parent, sibling, or grandparent) use to perform their daily activities. This study is being done to test the hypothesis that the daily use of energy in people who have a history of type 2 diabetes in their family will be different after they have slept short hours for 16 days in comparison to when they have slept longer hours for 16 days.

Study Overview

• Status: Completed
• Conditions: Sleep; Insulin Resistance; Type 2 Diabetes; Sleep Deprivation
• Intervention / Treatment: Other: 5.5-hour bedtime; Other: 8.5-hour bedtime

Detailed Description

Study participants will complete two 16-day inpatient stays in the sleep laboratory of the University of Chicago Clinical Resource Center that will be scheduled at least 4 weeks apart. Bedtime duration will be set at 5.5 hours per night during one of these stays and at 8.5 hours per night during the other. No daytime naps will be allowed. Study participants will be served regular daily meals including breakfast, lunch, dinner, and a bedtime snack. On weekdays all participants will engage in simulated "office work" in the sleep laboratory. During the rest of the time participants will maintain their usual indoor and outdoor activities as much as possible within the limits of the University of Chicago campus. At the beginning of each inpatient stay, study participants will drink a glass of water containing harmless non-radioactive dense forms of oxygen and hydrogen, small amounts of which are found in natural water. Several urine samples will be collected before and after the participants drink the water and again 14 days later in order to measure the amount of energy that was used by them during this time. At the end of each stay participants will also undergo measurements of their body composition (lean tissue, bone and fat) and their metabolic rate at rest and after a standard meal, and will complete tests to determine how much insulin does their body produce in response to an intravenous glucose infusion and how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Illinois
    • Chicago, Illinois, United States, 60637
      • University of Chicago

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• regular sleep habits
• BMI 20 to 27 kg/m2
• at least one parent, sibling or grandparent with type 2 diabetes
• must exercise regularly

Exclusion Criteria:

• active smoker
• night or shift work
• have highly variable sleep habits
• have a hormonal disorder
• have a sleep disorder
• have an active medical problem
• women only: use of birth control pills
• women only: irregular menstrual periods or pregnancy
• use of medications/compounds that can disrupt sleep

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 5.5-hour bedtime	Other: 5.5-hour bedtime; 16 days with sleep allowed only during a 5.5-hour bedtime period at night
Experimental: 8.5-hour bedtime	Other: 8.5-hour bedtime; 16 days with sleep allowed only during a 8.5-hour bedtime period at night

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Total energy expenditure	during each bedtime intervention

Secondary Outcome Measures

Outcome Measure	Time Frame
Physical activity related energy expenditure	during each bedtime intervention
Total body insulin sensitivity	at the end of each bedtime intervention
First and second phase insulin secretion	at the end of each bedtime intervention
Endogenous glucose production	at the end of each bedtime intervention
Glycerol turnover and free fatty acid concentration	at the end of each bedtime intervention

Collaborators and Investigators

• Sponsor: University of Chicago
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
• Investigators: Principal Investigator: Plamen D Penev, MD, PhD, University of Chicago

Study record dates

Study Major Dates

• Study Start: July 1, 2008
• Primary Completion (Actual): March 1, 2012
• Study Completion (Actual): March 1, 2012

Study Registration Dates

• First Submitted: July 25, 2008
• First Submitted That Met QC Criteria: July 25, 2008
• First Posted (Estimate): July 29, 2008

Study Record Updates

• Last Update Posted (Estimate): September 5, 2013
• Last Update Submitted That Met QC Criteria: September 4, 2013
• Last Verified: September 1, 2013

More Information

Terms related to this study

• Keywords: insulin secretion; energy expenditure; free fatty acids; insulin action; lipid turnover; short sleep duration
• Additional Relevant MeSH Terms: Mental Disorders; Glucose Metabolism Disorders; Metabolic Diseases; Nervous System Diseases; Dyssomnias; Sleep Wake Disorders; Neurologic Manifestations; Endocrine System Diseases; Hyperinsulinism; Diabetes Mellitus; Diabetes Mellitus, Type 2; Insulin Resistance; Sleep Deprivation
• Other Study ID Numbers: 16079A-S4; R01HL089637 (U.S. NIH Grant/Contract)