Effect of Weight Loss on Reproductive Function in Overweight Men

Effect of Weight Loss on Reproductive Function in Overweight Men.

Obesity has been found to be a risk factor for female infertility. Studies have indicated that obese men often have poor semen quality and require increased time to make partner pregnant. To date, no studies have investigated the effect of weight reduction on male fertility. The purpose of this study is to investigate the effect of weight reduction in overweight and obese men on their reproductive function.

Study Overview

• Status: Unknown
• Conditions: Obesity; Overweight
• Intervention / Treatment: Behavioral: weight loss

• Study Type: Observational
• Enrollment (Anticipated): 300

Contacts and Locations

• Study Contact: Name: Trine B. Haugen, PhD; Phone Number: +47 22453023; Email: Trine.B.Haugen@hioa.no
• Study Contact Backup: Name: Oliwia Witczak, PhD; Phone Number: + 4722452347; Email: Oliwia.Witczak@hioa.no

Study Locations

• Norway
  • Oslo, Norway, N-0130
    • Recruiting
    • Oslo University College
    • Contact: Trine B. Haugen, PhD; Phone Number: +47 45 3023; Email: Trine.B.Haugen@hioa.no
    • Contact: Oliwia Witczak, PhD; Phone Number: +47 67236277; Email: Oliwia.Witczak@hioa.no
    • Principal Investigator: Oliwia Witczak, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

• Sampling Method: Non-Probability Sample

Study Population

Obese and overweight men that are planing to loss weight by diet and/or lifestyle changes or gastric by-pass surgery.

Description

Inclusion Criteria:

• Age > 18
• BMI > 27 kg/m2

Exclusion Criteria:

-

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
weight, height, % body fat, sperm (volume, concentration, motility, morphology, vitality), sperm DNA integrity, steroid hormones, gonadotropins, blood glucose, HbA1c, mCRP, lipids, adiponectins, fatty acid composition in serum and sperm phospholipids	minimum three months

Secondary Outcome Measures

Outcome Measure	Time Frame
genetic variations in genes involved in metabolism and reproduction	no time frame

Collaborators and Investigators

• Sponsor: Oslo University College
• Collaborators: Oslo University Hospital; The Hospital of Vestfold; Tartu University Hospital
• Investigators: Study Chair: Trine B. Haugen, PhD, Oslo University College; Principal Investigator: Oliwia Witczak, PhD, Oslo University College

Study record dates

Study Major Dates

• Study Start: September 1, 2008
• Primary Completion (Anticipated): June 1, 2016

Study Registration Dates

• First Submitted: July 7, 2009
• First Submitted That Met QC Criteria: July 7, 2009
• First Posted (Estimate): July 8, 2009

Study Record Updates

• Last Update Posted (Estimate): April 21, 2015
• Last Update Submitted That Met QC Criteria: April 20, 2015
• Last Verified: March 1, 2014

More Information

Terms related to this study

• Keywords: overweight, obesity, male, fertility
• Additional Relevant MeSH Terms: Body Weight; Body Weight Changes; Weight Loss; Overweight
• Other Study ID Numbers: HiO 08/220b