- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01058356
Effect of Probiotic Lactobacilli (Lacidofil Cap®) for the Prevention of Antibiotic-Associated Diarrhea
April 15, 2010 updated by: Pharmbio Korea Co., Ltd.
Effect of Probiotic Lactobacilli (Lacidofil Cap®) for the Prevention of Antibiotic-Associated Diarrhea: Prospective, Randomized Double-blind, Multicenter Study
Antibiotic-Associated Diarrhea (AAD) is a common complication of antibiotic use.
The frequency of AAD can be high (26 - 60%) or moderate (13-29%) during hospital outbreaks and is relatively infrequent in outpatients.
The risk factors for AAD include broad-spectrum antibiotics, host factors (age, health status, and gender), hospitalization period and exposure to nosocomial pathogens.
AAD occurs 2-8 weeks after exposure to antibiotics as a result of disrupting normal intestinal microflora.
One of the roles of normal intestinal microflora is to act as a protective barrier that resists the colonization of intestinal pathogens.
These patients are susceptible to infection by opportunistic pathogens without this protective barrier.
Probiotic therapy is suited to AAD and Clostridium difficile disease.
Probiotics assist in reestablishing the disrupted intestinal microflora, enhancing immune responses and clearing pathogens and their toxins from the host.
Studies using probiotics have been reported for the past twenty-eight years (1977~2005), but the studies have been variable in trial designs and types of probiotics, had differing doses and durations of treatment, and thus have yielded controversial results.
The investigators will conduct a multi-center, randomized, placebo-controlled, double-blind trial to assess the efficacy of the probiotic Lactobacilli (Lacidofil cap®) for the prevention of AAD in adults.
Study Overview
Status
Completed
Study Type
Observational
Enrollment (Actual)
214
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Seoul, Korea, Republic of, 135-280
- KASID IBD Research Group
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Patients with respiratory tract infection who begin receiving antibiotic therapy (both hospitalized patients and out-patients)
Description
Inclusion Criteria:
- Male or female over 18
- Patients with respiratory tract infection who are receiving an oral or injection antibiotics.
- Signed informed consent form prior to inclusion in the study.
- Patients who begin receiving antibiotics within 48 hours before enrollment in this study.
Exclusion Criteria:
- Diagnosed Clostridium difficile colitis within the last 3 months
- Patients with tube feeding, ileostomy or colostomy
- Patients with basal diarrheal disease; acute enteritis, chronic diarrhea such as inflammatory bowel disease (IBD) etc, radiation enteritis, ischemic colitis and diarrhea caused by carcinoids etc.
- Patients receiving other probiotics during the last 15 days
- Patients treated with immunosuppressant drugs or immune deficiency patients
- Patients with radiotherapy and chemotherapy treatment for cancer.
- Patients treated with antidiarrheal, antispasmodic or motility agents for other diseases.
- Pregnant/Lactating women
- Patients with gastrointestinal (GI) surgery during the last 3 months.
- A history of hypersensitivity to cephalosporins, penicillin or clavulanic acid.
- Patients with verified diabetic autonomic neuropathy.
- Patients with organ transplants.
- Patients with underlying conditions or diseases which, in the opinion of the investigator, are unsuitable for inclusion.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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IBD research group in KASID
KASID is Korean Association Study of Intestinal Disease.
It has several research group suh as inflammatory bowel disease (IBD) research group.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Presence of AAD
Time Frame: Up to 14 days
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AAD defined as: Watery stools more than 3 times per day for at least 2 days.
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Up to 14 days
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Presence of Bowel Habit Change (Watery Stools More Than 2 Times Per Day for at Least 2 Days)
Time Frame: Up to14 days
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Up to14 days
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Sung-Ae Jung, MD, PhD, Ewha Womans University Mokdong Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2009
Primary Completion (Actual)
January 1, 2010
Study Completion (Actual)
February 1, 2010
Study Registration Dates
First Submitted
January 26, 2010
First Submitted That Met QC Criteria
January 27, 2010
First Posted (Estimate)
January 28, 2010
Study Record Updates
Last Update Posted (Estimate)
April 20, 2010
Last Update Submitted That Met QC Criteria
April 15, 2010
Last Verified
April 1, 2010
More Information
Terms related to this study
Keywords
- probiotics
- prevention
- lactobacilli
- pulmonary infection
- antibiotics associated colitis
- Prevention of antibiotics associated colitis
- the role of probiotics for prevention of antibiotics associated colitis
- the lactobacilli effect for antibiotics associated colitis
- antibiotic associated colitis on pulmonary infectious disease
Additional Relevant MeSH Terms
- Digestive System Diseases
- Infections
- Signs and Symptoms, Digestive
- Gastrointestinal Diseases
- Gastroenteritis
- Colonic Diseases
- Intestinal Diseases
- Bacterial Infections
- Bacterial Infections and Mycoses
- Gram-Positive Bacterial Infections
- Clostridium Infections
- Enterocolitis
- Diarrhea
- Colitis
- Enterocolitis, Pseudomembranous
Other Study ID Numbers
- KASID_lacidofil_1
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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