- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01197599
Acute Tendon and Nerve Responses to Exercise
Study Overview
Status
Conditions
Detailed Description
Background: Manual wheelchair propulsion is a primary source of mobility for many individuals with spinal cord injury (SCI). Propelling a manual wheelchair over an extended period often leads to arm pain and, subsequently, to secondary disability. Over 50% of manual wheelchair users with SCI experience arm pain that limits their activities of daily living. The prevalence of shoulder pain and carpal tunnel syndrome among manual wheelchair users is between 31% and 73%, and 49% and 73% respectively. A circuit training protocol has been developed to strengthen and protect the muscles of people with SCI, and has been shown to improve muscle strength and endurance, and reduce HDLcholesterol levels.
Purpose: The purpose of this study is to use ultrasound to analyze the effects of a bout of circuit training on the upper extremity of persons with SCI and able-bodied controls.
Hypotheses: All subjects will show an increase in nerve cross-sectional area after participation in the circuit training protocol. Nerves and tendons will become less echogenic after participation in the circuit training protocol. These changes will be more pronounced in persons with SCI.
Methods: Data collected will include history of pain, a physical exam, and ultrasound images of the nondominant upper extremity before and after a bout of circuit training, which includes exercises lifting weights and using an arm cycle. Before circuit training, ultrasound images will be collected once. After the circuit training, ultrasound images will be collected every 10 minutes over an hour. These images and will be used to measure the health and properties (such as size) of nerves, muscles, and tendons in the arm. Changes in these properties after a bout of circuit training will be related to history and physical exam information.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Florida
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Miami, Florida, United States, 33136
- The Miami Project to Cure Paralysis
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Spinal Cord Injury Cohort:
- any cause or severity of spinal cord injury
- at least 1 year post-injury
Able-Bodied Control Cohort:
- self-reported good health
Exclusion Criteria:
- history of non-dominant traumatic upper extremity injury to both wrist and shoulder
- history of cardiopulmonary or other disease for which intense activity carries any risk of harm
- a progressive or degenerative disability
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Spinal Cord Injury
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Able-Bodied Control
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Nerve cross-sectional area
Time Frame: 1 day (Visit 1)
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Nerve cross-sectional area will be measured via ultrasound.
Images will be collected at least once (pre-activity) and up to every 10 minutes over an hour (post-activity).
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1 day (Visit 1)
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Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- TMP-MN-003
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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