Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness (Surnutrition)

For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Study Overview

• Status: Completed
• Conditions: Lipid Overnutrition; Constitutional Thinness
• Intervention / Treatment: Behavioral: Lipid overnutrition

Detailed Description

This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

• Study Type: Observational
• Enrollment (Anticipated): 26

Contacts and Locations

Study Locations

• France
  • Clermont-Ferrand, France, 63000
    • CRNH Auvergne
  • Lyon, France, 69000
    • CRNH Rhone-Alpes
  • Saint-etienne, France, 42055
    • CHU de Saint-Etienne

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

Constitutionnal thinness women and healthy volonteers(women)

Description

Inclusion Criteria:

• consent form the study signed
• consent form for genetic study signed
• normal laboratory values for liver enzymes, glucose, lipid

Exclusion Criteria (common to the two groups):

• pregnant
• vegetarian
• heavy smoking
• heavy alcohol
• depressive
• taking hypolipidemic or antihypertensive drugs
• dyslipidemia

Study Plan

How is the study designed?

Design Details

• Time Perspectives: Prospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Constitutional thinness; Women with a a body mass index of less than 16.5 kg/m2	Behavioral: Lipid overnutrition; During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).
Healthy Volonteer; Women with a body mass index between 20 and 25 kg/m2	Behavioral: Lipid overnutrition; During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
gene expression	Level of genes (which regulate the lipid and energy metabolism) expression in fat and muscle tissues	After one month of lipid overnutrition

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anthropometric parameter	Lean mass	After one month of lipid overnutrition
Autonomic nervous system activity	Heart rate variability analyses using ECG Holter monitoring	After one month of lipid overnutrition
gastrointestinal hormone level	Serum level of GLP1	After one month of lipid overnutrition
Anthropometric parameter	Weight	After one month of lipid overnutrition
Anthropometric parameter	Fat mass	After one month of lipid overnutrition
gastrointestinal hormone level	Serum level of ghréline	After one month of lipid overnutrition
gastrointestinal hormone level	Serum level of PYY	After one month of lipid overnutrition

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Saint Etienne
• Collaborators: Ministry of Health, France
• Investigators: Principal Investigator: Bruno ESTOUR, MD PhD, CHU de Saint-Etienne

Study record dates

Study Major Dates

• Study Start: March 1, 2008
• Primary Completion (Actual): January 1, 2011
• Study Completion (Actual): January 1, 2011

Study Registration Dates

• First Submitted: October 18, 2010
• First Submitted That Met QC Criteria: October 19, 2010
• First Posted (Estimate): October 20, 2010

Study Record Updates

• Last Update Posted (Estimate): May 5, 2011
• Last Update Submitted That Met QC Criteria: May 4, 2011
• Last Verified: May 1, 2011

More Information

Terms related to this study

• Keywords: healthy volunteers; Thinness; Leanness; Lipid metabolism disorder
• Additional Relevant MeSH Terms: Nutrition Disorders; Body Weight; Thinness; Overnutrition
• Other Study ID Numbers: 0701047; 2007-A00744-49 (Other Identifier: Afssaps); DGS2007-0536 (Other Identifier: DGS)