- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01252498
Evaluation of the Role of Prostaglandins in Radiation-induced Mucositis
A Pilot Study to Evaluate the Role of Cyclooxygenase Pathway in Radiation Therapy and Chemoradiation Therapy Induced Mucositis in Head and Neck Cancer Patients
Study Overview
Status
Conditions
Detailed Description
Oral mucositis is a significant toxicity of radiation therapy and chemoradiation therapy in head and neck cancer patients. However the mechanisms that induce such mucositis are not completely understood. Previous work evaluating mucositis in bone marrow transplant patients has suggested that prostaglandin levels may be associated with the appearance of mucositis.
The present study will measure the levels in saliva of the prostaglandins PGE2 and PGI2 before, during, immediately after, and several weeks after radiotherapy for head and neck cancer. These salivary levels will be correlated with clinical observation of mucositis and patient reporting of pain levels.
Improved understanding of the mechanism of mucositis may lead to the development of more effective targeted agents to prevent this problem.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Vermont
-
Burlington, Vermont, United States, 05401
- Fletcher Allen Health Care
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Histologically proven locoregional Stage 4 squamous cell carcinoma of the oral cavity, larynx, oropharynx or hypopharynx
- Receiving radiation therapy or chemoradiation therapy to the oropharynx
- Older than 18 years old
- ECOG performance status of 0-2
- Life expectancy greater than 2 months
- Signed informed consent
Exclusion Criteria:
- Previous chemotherapy for this malignancy
- Previous radiotherapy to the head and neck
- Other cancer diagnosis within the last 5 years except for non-melanoma skin cancer or non-metastatic prostate cancer
- Patient taking NSAIDs
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Radiotherapy
Patients receiving radiotherapy or chemoradiotherapy for head and neck cancer
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Salivary levels of PGE2 and PGI2 during and after radiotherapy
Time Frame: 10 weeks after initiation of therapy
|
10 weeks after initiation of therapy
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Observed mucositis during and after radiotherapy
Time Frame: 10 weeks after initiation of radiotherapy
|
10 weeks after initiation of radiotherapy
|
Patient reports of oral pain during and after radiation therapy
Time Frame: 10 weeks after initiation of radiotherapy
|
10 weeks after initiation of radiotherapy
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Claire Verschraegen, MD, University of Vermont/Fletcher Allen Health Care
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- VCC1005
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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