- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01352923
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations
May 11, 2011 updated by: Universitaire Ziekenhuizen KU Leuven
In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.
Study Overview
Detailed Description
Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable, within well defined populations of healthy donors.
Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists.
Yet, numerous SNPs point towards proteins with previously unknown function in platelets, wich modulate the complex network of signaling events that regulate platelet function and further augment variability.
PEAR1 is mainly expressed in platelets and endothelial cells.
A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists.
However, hitherto, no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function.
Study Type
Interventional
Enrollment (Anticipated)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Alexandre Kauskot
- Email: alexandre.kauskot@med.kuleuven.be
Study Contact Backup
- Name: Peter Verhamme
- Email: Peter.Verhamme@uzleuven.be
Study Locations
-
-
Vlaams Brabant
-
Leuven, Vlaams Brabant, Belgium, 3000
- Recruiting
- KUleuven/UZ Gasthuisberg
-
Contact:
- Alexandre Kauskot
- Phone Number: +3216346145
-
Contact:
- Marc Houlaerts
- Phone Number: +3216346145
-
Principal Investigator:
- Marc Hoylaerts
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- healthy voluntary donors
Exclusion Criteria:
- none
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: peripheral blood
healthy voluntary donors
|
preparation of blood platelets
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Marc Hoylaerts, KU Leuven
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2011
Primary Completion (Anticipated)
May 1, 2012
Study Registration Dates
First Submitted
May 11, 2011
First Submitted That Met QC Criteria
May 11, 2011
First Posted (Estimate)
May 12, 2011
Study Record Updates
Last Update Posted (Estimate)
May 12, 2011
Last Update Submitted That Met QC Criteria
May 11, 2011
Last Verified
May 1, 2011
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- B322201111373
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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