Obesity as a Risk Factor for Musculoskeletal Diseases in the U.S. Air Force: Associations and Implications for Force Readiness

To study the first hypothesis, a retrospective cohort analysis of Air Force members from January 2005 to December 2010 will be performed to evaluate the association of obesity as an independent predictor variable with musculoskeletal disease as the dependent variable.

Study Overview

• Status: Completed
• Conditions: Obesity

Detailed Description

To study the first hypothesis, a retrospective cohort analysis of Air Force members from January 2005 to December 2010 will be performed to evaluate the association of obesity as an independent predictor variable with musculoskeletal disease as the dependent variable. A second analysis will be performed on the same cohort using musculoskeletal disease as an independent predictor variable, as well as evaluating a potential interaction between obesity and musculoskeletal disease, to determine the association of these variables with the dependent variable of service member readiness for duty. The independent variables for the analyses include:

• Age
• Sex
• BMI
• Fitness data (PIMR: PFT scores, weight, height, BMI, abdominal circumference)
• Profile data (PIMR: Number of profiles, number of profiles due to musculoskeletal diagnoses, total days on duty limitation, total days on mobility limitation)
• Total number of deployments served
• All new musculoskeletal diagnoses (see attached abbreviated ICD-9 list)
• Incidence of member separation from AF
• Incidence of disability retirement
• X-rays
• Surgeries (orthopaedic, general)
• Referrals to the Orthopaedic Department
• Referrals to the Pain Clinic
• New diagnosis of diabetes mellitus
• Death

All data will be gathered by SG6H, Healthcare Informatics Division, and de-identified. Then the de-identified data will be coded and sent to the Principal Investigator for analysis. All informational data sets will be totally de-identified prior to releasing to the Principle Investigator to be analyzed by a statistician.

• Study Type: Observational
• Enrollment (Actual): 67904

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

DoD Beneficiaries

Description

Exclusion: Active Duty Air Force members with the following conditions will be excluded from the study:

• Documented preexisting musculoskeletal injury/disease before onset of obesity
• Hypothyroidism/Hyperthyroidism
• Hyperparathyroidism
• Osteopenia/Osteoporosis
• Nicotine dependence
• Alcohol dependence
• Eating disorders (anorexia nervosa, bulimia nervosa)
• Cancer requiring chemotherapy or radiation therapy
• Status-post gastrectomy
• Status-post bilateral oophorectomy
• Crohn's Disease
• Ulcerative Colitis
• Celiac Disease
• Cushing's Disease
• Prior to or during the study period, more than 6 months of taking proton pump inhibitors, medroxyprogesterone acetate, bisphosphonates, methotrexate, selective serotonin reuptake inhibitors, or inhaled/intranasal corticosteroids
• Prior to or during the study period, more than 1 month of taking fluoroquinolones, oral or intramuscular corticosteroids, oral or intramuscular testosterone, or leuprolide

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

DoD Beneficiaries; Exclusion: Active Duty Air Force members with the following conditions will be excluded from the study: Documented preexisting musculoskeletal injury/disease before onset of obesity; Hypothyroidism/Hyperthyroidism; Hyperparathyroidism; Osteopenia/Osteoporosis; Nicotine dependence; Alcohol dependence; Eating disorders (anorexia nervosa, bulimia nervosa); Cancer requiring chemotherapy or radiation therapy; Status-post gastrectomy; Status-post bilateral oophorectomy; Crohn's Disease; Ulcerative Colitis; Celiac Disease; Cushing's Disease; Prior to or during the study period, more than 6 months of taking proton pump inhibitors, medroxyprogesterone acetate, bisphosphonates, methotrexate, selective serotonin reuptake inhibitors, or inhaled/intranasal corticosteroids; Prior to or during the study period, more than 1 month of taking fluoroquinolones, oral or intramuscular corticosteroids, oral or intramuscular testosterone, or leuprolide

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Obesity vs musculoskeletal disease risk	within 7 years

Collaborators and Investigators

• Sponsor: Mike O'Callaghan Military Hospital
• Investigators: Principal Investigator: Nathaniel Nye, MD, Mike O'Callaghan Military Hospital

Study record dates

Study Major Dates

• Study Start: March 1, 2012
• Primary Completion (Actual): November 1, 2013
• Study Completion (Actual): November 1, 2013

Study Registration Dates

• First Submitted: June 4, 2012
• First Submitted That Met QC Criteria: June 5, 2012
• First Posted (Estimate): June 6, 2012

Study Record Updates

• Last Update Posted (Estimate): October 16, 2014
• Last Update Submitted That Met QC Criteria: October 15, 2014
• Last Verified: July 1, 2013

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Obesity
• Other Study ID Numbers: FWH20120036H