- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01730040
Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)
July 29, 2015 updated by: Regeneron Pharmaceuticals
A Randomized, Double-Blind Study of the Efficacy and Safety of Alirocumab Added on to Atorvastatin Versus Ezetimibe Added on to Atorvastatin Versus Atorvastatin Dose Increase Versus Switch to Rosuvastatin in Patients Who Are Not Controlled on Atorvastatin
This is a randomized, double-blind, active-comparator, parallel-group study in patients at high cardiovascular risk with nonfamilial hypercholesterolemia or heterozygous familial hypercholesterolemia (heFH).
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
355
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Herston QLD, Australia
-
New Lambton Heights, Australia
-
Perth, Australia
-
Sherwood, Australia
-
Woolloongabba, Australia
-
-
-
-
Ontario
-
Brampton, Ontario, Canada
-
Etobicoke, Ontario, Canada
-
London, Ontario, Canada
-
Newmarke, Ontario, Canada
-
Thornhill, Ontario, Canada
-
Toronto, Ontario, Canada
-
-
Quebec
-
Chicoutimi, Quebec, Canada
-
-
-
-
-
Dijon, France
-
Lille, France
-
Venissieux, France
-
-
-
-
-
Bad Oeynhausen, Germany
-
Berlin, Germany
-
Koeln, Germany
-
Munich, Germany
-
Regensburg, Germany
-
Ulm, Germany
-
-
-
-
-
Chiete, Italy
-
Genova, Italy
-
Napoli, Italy
-
Palermo, Italy
-
Roma (2 locations), Italy
-
-
-
-
-
Distrito Federal, Mexico
-
Guadalajara, Mexico
-
Guadalajara, Jalisco, Mexico
-
Monterrey Nuevo Leon, Mexico
-
Tijuana Baja California, Mexico
-
Zapopan Jalisco, Mexico
-
-
-
-
-
Barcelona (3 locations), Spain
-
Madrid, Spain
-
Sant Joan Despi, Spain
-
-
-
-
-
Carmarthen, United Kingdom
-
Chester, United Kingdom
-
Peterborough, United Kingdom
-
Salford, United Kingdom
-
Stevenage, United Kingdom
-
West Bromwich, West Midlands, United Kingdom
-
-
-
-
Alabama
-
Mobile, Alabama, United States
-
-
Arizona
-
Chandler, Arizona, United States
-
Tucson, Arizona, United States
-
-
California
-
Anaheim, California, United States
-
Beverly Hills, California, United States
-
Lakeland, California, United States
-
Newport Beach, California, United States
-
Northridge, California, United States
-
Sacramento, California, United States
-
Walnut Creek, California, United States
-
-
Connecticut
-
Milford, Connecticut, United States
-
-
Florida
-
Atlantis, Florida, United States
-
Boca Raton, Florida, United States
-
Clearwater, Florida, United States
-
Jacksonville, Florida, United States
-
Miami (2 locations), Florida, United States
-
Oviedo, Florida, United States
-
Pinellas Park, Florida, United States
-
Port Orange, Florida, United States
-
Sarasota, Florida, United States
-
Tampa, Florida, United States
-
West Palm Beach, Florida, United States
-
-
Idaho
-
Boise, Idaho, United States
-
Meridian, Idaho, United States
-
-
Illinois
-
Chicago, Illinois, United States
-
Morton, Illinois, United States
-
-
Indiana
-
Indianapolis, Indiana, United States
-
-
Kansas
-
Newton, Kansas, United States
-
Overland Park, Kansas, United States
-
Wichita, Kansas, United States
-
-
Kentucky
-
Lexington, Kentucky, United States
-
Louisville, Kentucky, United States
-
-
Maine
-
Auburn, Maine, United States
-
-
Maryland
-
Bethesda, Maryland, United States
-
-
Minnesota
-
Edina, Minnesota, United States
-
Rochester, Minnesota, United States
-
-
Mississippi
-
Olive Branch, Mississippi, United States
-
Port Gibson, Mississippi, United States
-
-
Missouri
-
St. Louis, Missouri, United States
-
-
Montana
-
Butte, Montana, United States
-
-
Nevada
-
Las Vegas, Nevada, United States
-
-
New York
-
Williamsville, New York, United States
-
-
North Carolina
-
Winston-Salem, North Carolina, United States
-
-
Ohio
-
Cleveland, Ohio, United States
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States
-
-
Rhode Island
-
Warwick, Rhode Island, United States
-
-
South Carolina
-
Greer, South Carolina, United States
-
Summerville, South Carolina, United States
-
-
Tennessee
-
Kingsport, Tennessee, United States
-
-
Texas
-
Dallas (2 locations), Texas, United States
-
Fort Worth, Texas, United States
-
Houston, Texas, United States
-
-
Utah
-
Bountiful, Utah, United States
-
Marion, Utah, United States
-
Salt Lake City, Utah, United States
-
-
Washington
-
Renton, Washington, United States
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients with screening (visit 1) LDL-C greater than or equal to 70 mg/dL with documented CVD, not adequately controlled with a daily dose of atorvastatin. OR
- Patients with screening (visit 1) LDL-C greater than or equal to 100 mg/dL at high risk for CVD who are not adequately controlled with a daily dose of atorvastatin.
Exclusion Criteria:
- LDL-C greater than 250 mg/dL
- LDL-C less than 70 mg/dL at the screening visit in patients with history of documented CVD
- LDL-C less than 100 mg/dL at the screening visit in patients without history of documented CHD or non-CHD CVD, but with other risk factors
- TG greater than 400 mg/dL
- Homozygous FH (clinically or previous genotyping)
- Currently taking a statin that is not atorvastatin
- Currently taking Ezetimibe (EZE)
- Not on a stable dose of allowable lipid modifying treatments (LMT)
(The inclusion/ exclusion criteria provided above is not intended to contain all considerations relevant to a patient's potential participation in this clinical trial).
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Atorvastatin 40 mg
Participants, who were receiving atorvastatin 20 mg over-encapsulated tablets orally at baseline, received atorvastatin 40 mg over-encapsulated tablets orally once daily (QD), placebo for alirocumab SC injection every two weeks (Q2W), and placebo for ezetimibe over-encapsulated tablets orally QD added to stable Lipid-Modifying Therapy (LMT) for 24 weeks.
|
Placebo for alirocumab and ezetimibe.
Atorvastatin over-encapsulated tablets orally.
|
Active Comparator: Ezetimibe 10 mg + Atorvastatin 20 mg
Participants, who were receiving atorvastatin 20 mg over-encapsulated tablets orally at baseline, received ezetimibe 10 mg over-encapsulated tablets orally QD, atorvastatin 20 mg over-encapsulated tablets orally QD, and placebo for alirocumab SC injection Q2W added to stable LMT for 24 weeks.
|
Placebo for alirocumab and ezetimibe.
Atorvastatin over-encapsulated tablets orally.
Ezetimibe over-encapsulated tablet orally.
Other Names:
|
Experimental: Alirocumab 75 mg/up to 150 mg + Atorvastatin 20 mg
Participants, who were receiving atorvastatin 20 mg over-encapsulated tablets orally at baseline, received Alirocumab 75 mg SC injection Q2W, atorvastatin 20 mg over-encapsulated tablets orally QD, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks.
Alirocumab dose up-titrated to 150 mg Q2W from Week 12 when LDL-C levels ≥70 mg/dL (1.81 mmol/L) or ≥100 mg/dL (2.59 mmol/L) at Week 8, based on baseline disease characteristic and medical history.
|
Placebo for alirocumab and ezetimibe.
Alirocumab administered as a SC injection of 1 mL into the abdomen, thigh, or outer area of the upper arm.
Other Names:
Atorvastatin over-encapsulated tablets orally.
|
Active Comparator: Atorvastatin 80 mg
Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received Atorvastatin 80 mg over-encapsulated tablets orally QD, placebo for alirocumab SC injection Q2W, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks.
|
Placebo for alirocumab and ezetimibe.
Atorvastatin over-encapsulated tablets orally.
|
Active Comparator: Rosuvastatin 40 mg
Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received rosuvastatin 40 mg over-encapsulated tablets orally QD, placebo for alirocumab SC injection Q2W, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks.
|
Rosuvastatin over-encapsulated tablets orally.
Other Names:
Placebo for alirocumab and ezetimibe.
|
Active Comparator: Ezetimibe 10 mg + Atorvastatin 40 mg
Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received ezetimibe 10 mg over-encapsulated tablets orally QD, atorvastatin 40 mg over-encapsulated tablets orally QD, and placebo for alirocumab SC injection Q2W added to stable LMT for 24 weeks.
|
Placebo for alirocumab and ezetimibe.
Atorvastatin over-encapsulated tablets orally.
Ezetimibe over-encapsulated tablet orally.
Other Names:
|
Experimental: Alirocumab 75 mg/ up to 150 mg + Atorvastatin 40 mg
Participants, who were receiving atorvastatin 40 mg over-encapsulated tablets orally at baseline, received alirocumab 75 mg SC injection Q2W, atorvastatin 40 mg over-encapsulated tablets orally QD, and placebo for ezetimibe over-encapsulated tablets orally QD added to stable LMT for 24 weeks.
Alirocumab dose up-titrated to 150 mg Q2W from Week 12 when LDL-C levels ≥70 mg/dL (1.81 mmol/L) or ≥100 mg/dL (2.59 mmol/L) at Week 8, based on baseline disease characteristic and medical history.
|
Placebo for alirocumab and ezetimibe.
Alirocumab administered as a SC injection of 1 mL into the abdomen, thigh, or outer area of the upper arm.
Other Names:
Atorvastatin over-encapsulated tablets orally.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percent Change From Baseline in Calculated LDL-C at Week 24 - Intent-to-treat (ITT) Analysis
Time Frame: From Baseline to Week 24
|
Calculated LDL-C values were obtained from Friedewald formula.
Adjusted Least-squares (LS) means and standard errors at Week 24 were obtained from a mixed-effect model with repeated measures (MMRM) to account for missing data.
All available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment were used in the model (ITT analysis).
|
From Baseline to Week 24
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percent Change From Baseline in Total Cholesterol (Total-C) at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Apo B at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Non-HDL-C at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Total-C at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in HDL-C at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in HDL-C at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Apolipoprotein (Apo) B at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Non-High-density Lipoprotein Cholesterol (Non-HDL-C) at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Apo A-1 at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Apo A-1 at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Calculated LDL-C at Week 24 - On-Treatment Analysis
Time Frame: From Baseline to Week 24
|
Calculated LDL-C values were obtained from Friedewald formula.
Adjusted LS means and standard errors at Week 24 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first) (on-treatment analysis).
|
From Baseline to Week 24
|
Percent Change From Baseline in Calculated LDL-C at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Calculated LDL-C values were obtained from Friedewald formula.
Adjusted LS means and standard errors at Week 12 from MMRM model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment (ITT analysis).
|
From Baseline to Week 24
|
Percent Change From Baseline in Calculated LDL-C at Week 12 - On-Treatment Analysis
Time Frame: From Baseline to Week 24
|
Calculated LDL-C values were obtained from Friedewald formula.
Adjusted LS means and standard errors at Week 12 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first) (on-treatment analysis).
|
From Baseline to Week 24
|
Percent Change From Baseline in Apo B at Week 24 - On-Treatment Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (ie. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first).
|
From Baseline to Week 24
|
Percent Change From Baseline in Non-HDL-C at Week 24 - On-Treatment Analysis
Time Frame: From Baseline to Week 24
|
Adjusted LS means and standard errors at Week 24 were obtained from MMRM model including available post-baseline on-treatment data from Week 4 to Week 24 (i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first).
|
From Baseline to Week 24
|
Percentage of Very High CV Risk Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) or High CV Risk Participants Reaching Calculated LDL-C <100 mg/dL (2.59 mmol/L) at Week 24 - ITT Analysis
Time Frame: Up to Week 24
|
Adjusted percentages at Week 24 were obtained from a multiple imputation approach model for handling of missing data.
All available post-baseline data from Week 4 to week 24 regardless of status on- or off-treatment were included in the imputation model (ITT analysis).
|
Up to Week 24
|
Percentage of Very High CV Risk Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) or High CV Risk Participants Reaching Calculated LDL-C <100 mg/dL (2.59 mmol/L) at Week 24 - On-Treatment Analysis
Time Frame: Up to Week 24
|
Adjusted percentages at Week 24 were obtained from a multiple imputation approach model including available post-baseline on-treatment data from Week 4 to Week 24 i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first (on-treatment analysis).
|
Up to Week 24
|
Percentage of Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) at Week 24 - ITT Analysis
Time Frame: Up to Week 24
|
Adjusted percentages at Week 24 were obtained from a multiple imputation approach model for handling of missing data.
All available post-baseline data from Week 4 to week 24 regardless of status on- or off-treatment were included in the imputation model (ITT analysis).
|
Up to Week 24
|
Percentage of Participants Reaching Calculated LDL-C <70 mg/dL (1.81 mmol/L) at Week 24 - On-Treatment Analysis
Time Frame: Up to Week 24
|
Adjusted percentages at Week 24 were obtained from a multiple imputation approach model including available post-baseline on-treatment data from Week 4 to Week 24 i.e. up to 21 days after last injection or 3 days after the last capsule [whatever atorvastatin, rosuvastatin or ezetimibe], whichever came first (on-treatment analysis).
|
Up to Week 24
|
Percent Change From Baseline in Lipoprotein(a) at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted means and standard errors at Week 24 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Fasting Triglycerides at Week 24 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted means and standard errors at Week 24 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Lipoprotein(a) at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted means and standard errors at Week 12 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Percent Change From Baseline in Fasting Triglycerides at Week 12 - ITT Analysis
Time Frame: From Baseline to Week 24
|
Adjusted means and standard errors at Week 12 from from a multiple imputation approach model including all available post-baseline data from Week 4 to Week 24 regardless of status on- or off-treatment.
|
From Baseline to Week 24
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Mahmood T, Minnier J, Ito MK, Li QH, Koren A, Kam IW, Fazio S, Shapiro MD. Discordant responses of plasma low-density lipoprotein cholesterol and lipoprotein(a) to alirocumab: A pooled analysis from 10 ODYSSEY Phase 3 studies. Eur J Prev Cardiol. 2021 Jul 23;28(8):816-822. doi: 10.1177/2047487320915803. Epub 2020 Apr 10.
- Leiter LA, Tinahones FJ, Karalis DG, Bujas-Bobanovic M, Letierce A, Mandel J, Samuel R, Jones PH. Alirocumab safety in people with and without diabetes mellitus: pooled data from 14 ODYSSEY trials. Diabet Med. 2018 Dec;35(12):1742-1751. doi: 10.1111/dme.13817. Epub 2018 Oct 9.
- Ray KK, Ginsberg HN, Davidson MH, Pordy R, Bessac L, Minini P, Eckel RH, Cannon CP. Reductions in Atherogenic Lipids and Major Cardiovascular Events: A Pooled Analysis of 10 ODYSSEY Trials Comparing Alirocumab With Control. Circulation. 2016 Dec 13;134(24):1931-1943. doi: 10.1161/CIRCULATIONAHA.116.024604. Epub 2016 Oct 24.
- Robinson JG, Colhoun HM, Bays HE, Jones PH, Du Y, Hanotin C, Donahue S. Efficacy and safety of alirocumab as add-on therapy in high-cardiovascular-risk patients with hypercholesterolemia not adequately controlled with atorvastatin (20 or 40 mg) or rosuvastatin (10 or 20 mg): design and rationale of the ODYSSEY OPTIONS Studies. Clin Cardiol. 2014 Oct;37(10):597-604. doi: 10.1002/clc.22327. Epub 2014 Sep 30.
- Bays H, Gaudet D, Weiss R, Ruiz JL, Watts GF, Gouni-Berthold I, Robinson J, Zhao J, Hanotin C, Donahue S. Alirocumab as Add-On to Atorvastatin Versus Other Lipid Treatment Strategies: ODYSSEY OPTIONS I Randomized Trial. J Clin Endocrinol Metab. 2015 Aug;100(8):3140-8. doi: 10.1210/jc.2015-1520. Epub 2015 Jun 1.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2012
Primary Completion (Actual)
April 1, 2014
Study Completion (Actual)
May 1, 2014
Study Registration Dates
First Submitted
November 9, 2012
First Submitted That Met QC Criteria
November 14, 2012
First Posted (Estimate)
November 21, 2012
Study Record Updates
Last Update Posted (Estimate)
August 31, 2015
Last Update Submitted That Met QC Criteria
July 29, 2015
Last Verified
July 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Metabolic Diseases
- Lipid Metabolism Disorders
- Hyperlipidemias
- Dyslipidemias
- Hypercholesterolemia
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antimetabolites
- Anticholesteremic Agents
- Hypolipidemic Agents
- Lipid Regulating Agents
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Atorvastatin
- Rosuvastatin Calcium
- Ezetimibe
Other Study ID Numbers
- R727-CL-1110
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hypercholesterolemia
-
National Medical Research Center for Therapy and...Moscow State University of Medicine and DentistryRecruitingMedication Adherence | Adherence, Medication | Treatment Adherence | Familial Hypercholesterolemia | Motivational Interviewing | Adherence, Patient | Treatment Adherence and Compliance | Patient Compliance | Adherence | Hypercholesterolemia, Familial | Patient Adherence | Hypercholesterolemia, Autosomal Dominant and other conditionsRussian Federation
-
Direct PlantesUnknownHYPERCHOLESTEROLEMIAFrance
-
Chong Kun Dang PharmaceuticalRecruitingPrimary HypercholesterolemiaKorea, Republic of
-
Provident Clinical ResearchGlaxoSmithKlineCompletedPrimary HypercholesterolemiaUnited States
-
Addpharma Inc.CompletedPrimary HypercholesterolemiaKorea, Republic of
-
JW PharmaceuticalCompletedPrimary HypercholesterolemiaKorea, Republic of
-
Hanmi Pharmaceutical Company LimitedCompletedPrimary HypercholesterolemiaKorea, Republic of
-
Organon and CoCompletedPrimary Hypercholesterolemia | Homozygous Familial Hypercholesterolemia
-
Merck Sharp & Dohme LLCTerminated
-
Danone JapanCompletedHealthy | Mild HypercholesterolemiaJapan
Clinical Trials on Rosuvastatin
-
AstraZenecaCompletedDyslipidemia | Kidney DiseaseUnited States, Puerto Rico
-
Yuhan CorporationCompletedHypertension | HyperlipidemiaKorea, Republic of
-
Ottawa Hospital Research InstituteUnknownVenous ThromboembolismCanada, Norway
-
Kobe UniversityCompletedCoronary Artery Disease Progression
-
National Institute of Diabetes and Digestive and...National Institute on Alcohol Abuse and Alcoholism (NIAAA); National Cancer... and other collaboratorsRecruitingCirrhosis | Cirrhosis, Liver | Cirrhosis Due to Hepatitis B | Cirrhosis Due to Hepatitis C | Cirrhosis Early | Cirrhosis Advanced | Cirrhosis Infectious | Cirrhosis Alcoholic | Cirrhosis, Biliary | Cirrhosis Cryptogenic | Cirrhosis Due to Primary Sclerosing CholangitisUnited States
-
Gachon University Gil Medical CenterDaewoong Pharmaceutical Co. LTD.UnknownCoronary Artery DiseaseKorea, Republic of
-
Alvogen KoreaCompletedPrimary HypercholesterolemiaKorea, Republic of
-
Hanmi Pharmaceutical Company LimitedUnknownHealthyKorea, Republic of
-
Organon and CoCompleted