Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

June 25, 2013 updated by: G. Harvey Anderson, University of Toronto

Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men.

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Ontario
      • Toronto, Ontario, Canada, M5S 3E2
        • Department of Nutritional Sciences, University of Toronto

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

9 years to 29 years (Child, Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Born at full term
  • Men Age:20-29 years/BMI: 20-25
  • Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion Criteria:

  • Smokers
  • Dieters
  • Individuals with lactose intolerance, allergies to milk and dairy products
  • Individuals with gastrointestinal problems
  • Individuals with diabetes or other metabolic diseases
  • Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: water with resting condition
Experimental: glucose with resting condition
Other: Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation
Experimental: water with exercise condition
Other: Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation
Experimental: glucose with exercise condition
Other: Glucose Preload and Exercise Intervention
A glucose preload and exercise were administered to examine the modulate substrate oxidation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Food Intake
Time Frame: 60 - 90 min in the study
Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.
60 - 90 min in the study

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Net Energy Balance
Time Frame: 0-90 min in the study
Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise.
0-90 min in the study

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Toronto

Collaborators

Canadian Institutes of Health Research (CIHR)

Investigators

  • Principal Investigator: Harvey Anderson, Ph.D., University of Toronto

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2011

Primary Completion (Actual)

August 1, 2012

Study Completion (Actual)

August 1, 2012

Study Registration Dates

First Submitted

June 22, 2013

First Submitted That Met QC Criteria

June 25, 2013

First Posted (Estimate)

June 28, 2013

Study Record Updates

Last Update Posted (Estimate)

June 28, 2013

Last Update Submitted That Met QC Criteria

June 25, 2013

Last Verified

June 1, 2013

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • CIHR kids_26570
  • CIHR MOP-111250 (Other Grant/Funding Number: 111250)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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