- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01934621
Adapting Daily Activity Performance Through Strategy Training (ADAPTS)
November 3, 2020 updated by: Elizabeth R. Skidmore, PhD, OTR/L, University of Pittsburgh
Closing the Gap: Early Intervention for Cognitive Disability After Stroke
Individuals with cognitive impairments after stroke sustain significant disability in their daily tasks, and account for a significant proportion of stroke-related healthcare costs.
The proposed study examines a novel intervention, strategy training, that shows promise for helping individuals with stroke-related cognitive impairments reduce disability in daily tasks, which may lead to reductions in healthcare costs.
We predict that strategy training will result in significantly greater independence 6 months after stroke compared to an attention control intervention, and that strategy training may reduce cognitive impairments.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
128
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Pennsylvania
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Pittsburgh, Pennsylvania, United States, 15260
- University of Pittsburgh
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- primary diagnosis of acute stroke
- admission to acute inpatient rehabilitation
- impairment in higher order cognitive functions (EXIT-14 ≥ 3)
Exclusion Criteria:
- pre-stroke diagnosis of dementia in the medical record
- inability to follow two- step commands 80% of the time
- severe aphasia (BDAE ≤ 1)
- current major depressive, bipolar, or psychotic disorder
- drug or alcohol abuse within 3 months
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Strategy Training
Strategy training is a form of meta-cognitive instruction that trains individuals with stroke-related cognitive impairments to identify and prioritize problematic daily activities, identify the barriers impeding performance, generate and evaluate their own strategies to address barriers, and apply these skills through iterative practice.
Participants use printed workbooks to learn and apply this method.
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Placebo Comparator: Attention Control
The attention control intervention will control for the non-specific effects of strategy training.
The therapists will administer the standardized and dose-matched protocol, using scripted open-ended questions to facilitate participants' reflections on their rehabilitation activities and experiences.
In lieu of the strategy training workbook materials, participants will complete a daily journal, and discuss their entries during attention control sessions.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Independence with Daily Activities
Time Frame: Baseline to Month 6
|
Moderate effect size of difference between groups in independence (measured with the Functional Independence Measure)
|
Baseline to Month 6
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Executive Functions
Time Frame: Baseline to Month 6
|
Moderate effect size of difference between groups in independence (measured with selected indices of the Delis-Kaplan Executive Function System)
|
Baseline to Month 6
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Elizabeth R Skidmore, PhD, OTR/L, University of Pittsburgh
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
November 1, 2013
Primary Completion (Actual)
May 1, 2018
Study Completion (Actual)
September 1, 2020
Study Registration Dates
First Submitted
August 29, 2013
First Submitted That Met QC Criteria
August 29, 2013
First Posted (Estimate)
September 4, 2013
Study Record Updates
Last Update Posted (Actual)
November 5, 2020
Last Update Submitted That Met QC Criteria
November 3, 2020
Last Verified
November 1, 2020
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- PRO13070029
- R01HD074693 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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