Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men

A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.

Study Overview

• Status: Suspended
• Conditions: Obesity; Metabolic Syndrome; Insulin Resistance
• Intervention / Treatment: Behavioral: Exercise

• Study Type: Interventional
• Enrollment (Anticipated): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Glasgow, United Kingdom, G12 8QQ
    • University of Glasgow

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• male
• 18-40 years
• undertaking < 1 hour per week of planned exercise

Exclusion Criteria:

• BMI > 35 kg/m2
• Blood pressure > 160/90 mm Hg (on anti-hypertensive medication)
• history of established coronary heart disease
• family history of early cardiac death (<40 years)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Exercise; 4 week supervised high-intensity shuttle running intervention, with 3 sessions per week (12 sessions in total)	Behavioral: Exercise; 4-week supervised high intensity shuttle running intervention, 3 sessions per week (12 sessions in total)
No Intervention: Control; No intervention - participants maintain usual lifestyle

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Insulin sensitivity	Assessed from glucose and insulin concentrations in fasted state and during oral glucose tolerance test.	Change from baseline immediately post-intervention (4 weeks after baseline)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Resting substrate utilization	Metabolic rate and fat and carbohydrate oxidation estimated via indirect calorimetry	Change from baseline immediately post-intervention (4 weeks after baseline)
Endurance exercise performance	Time taken to complete 100 x 10m shuttle runs	Change from baseline immediately post-intervention (4 weeks after baseline)
Sprint exercise performance	Time taken to complete 10 x 10m shuttle runs	Change from baseline immediately post-intervention (4 weeks after baseline)
Body weight		Change from baseline immediately post-intervention (4 weeks after baseline)
Waist circumference		Change from baseline immediately post-intervention (4 weeks after baseline)
Percentage body fat		Change from baseline immediately post-intervention (4 weeks after baseline)
Clustered Cardiometabolic Risk Score	Clustered Cardiometabolic Risk Score = -zHDL+zInsulin+zGlucose+zTriglycerides+( zBMI+zWC)/2+(zSBP+zDBP)/2.	Change from baseline immediately post-intervention (4 weeks after baseline)

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Objectively measured physical activity	Time spent sedentary and physically active assessed by accelerometer	Change from baseline to week 4 of intervention

Collaborators and Investigators

• Sponsor: University of Glasgow

Study record dates

Study Major Dates

• Study Start: October 1, 2013
• Primary Completion (Anticipated): July 1, 2017
• Study Completion (Anticipated): December 1, 2017

Study Registration Dates

• First Submitted: October 8, 2013
• First Submitted That Met QC Criteria: October 10, 2013
• First Posted (Estimate): October 14, 2013

Study Record Updates

• Last Update Posted (Estimate): June 3, 2016
• Last Update Submitted That Met QC Criteria: June 2, 2016
• Last Verified: June 1, 2016

More Information

Terms related to this study

• Keywords: Exercise; Insulin resistance; Physical activity; Blood pressure; Lipids; Fitness; High intensity interval training; Fat oxidation
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Hyperinsulinism; Metabolic Syndrome; Insulin Resistance
• Other Study ID Numbers: FBLS1020