- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02012426
The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight (SWSS)
May 31, 2017 updated by: Dr Graham Finlayson, University of Leeds
The aim of the current study is to demonstrate that a commercial weight management diet (i.e. low energy density) influences satiation, hunger and satiety and leads to lower energy intake during ad-libitum meals and over a full day. We further seek to demonstrate the sustainability of this effect following 12- week weight loss on the weight management program.
- We hypothesise that formulated (low energy) meals will lead to decreased hunger, greater fullness and reduced desire to eat compared to standard meals.
- We hypothesise that the commercial weight management program will lead to greater weight loss compared to control program.
- We hypothesise that formulated meals (high consumer acceptance) will improve hedonic control over eating (lower wanting for high fat food)
- We hypothesise that the commercial weight management program will improve hedonic control over eating (reduced experience food cravings)
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
96
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
West Yorkshire
-
Leeds, West Yorkshire, United Kingdom, LS2 9JT
- University of Leeds
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- BMI of 28 - 45 kg/m2
- Reporting an interest in weight loss, not actively participating in a commercial weight loss program,
- Not increased physical activity levels in the past 2-4 weeks
- Able to eat most everyday foods and fruits and vegetables
- Written informed consent to be given
Exclusion Criteria:
- Significant health problems that could cause confounding effects between intervention and control.
- Taking any medication or supplements known to affect appetite or weight within the past month and/or during the study
- Pregnant, planning to become pregnant or breastfeeding
- History of anaphylaxis to food
- Known food allergies or food intolerance
- Smokers and those who have recently ceased smoking
- Participants receiving systemic or local treatment likely to interfere with evaluation of the study parameters
- Those who have previously taken part in a commercial weight loss program in the last 6 months? .
- Participants who work in appetite or feeding related areas
- Participants unable to consume foods used in the study
- Participants who have had bariatric surgery
- Participants with a history of eating disorder
- Presence of untreated hypothyroidism
- Inability to fully comply with intervention or study procedures
- Insufficient English language skills to complete study questionnaires
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Intervention Group
Participants enrolled in commercial weight management program
|
|
Active Comparator: Control group
Participants enrolled in standard care weight management provision
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Test Meal Energy Intake
Time Frame: Week 0 and week 12
|
Measured reductions in ad-libitum energy intake following consumption of formulated test meal in comparison to control.
|
Week 0 and week 12
|
24h Energy Intake
Time Frame: Week 0 and week 12
|
Measured reduction in total within-day energy intake following consumption of formulated meals in comparison to control
|
Week 0 and week 12
|
Appetite sensations
Time Frame: Week 0 and week 14
|
Measured reduction in hunger and increase in satiety quotient following consumption of formulated test meal in comparison to equi-energetic control
|
Week 0 and week 14
|
Food preference
Time Frame: Week 0 and week 14
|
Measured changes in food preference and liking and wanting profiles for food (HF<LF) following consumption of formulated test meal in comparison to equi-energetic control
|
Week 0 and week 14
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Body Weight
Time Frame: Weekly from week 0 to week 12
|
Measured change in weight and energy balance parameters over a 12 week period following participation in commercial weight management program compared to control group.
|
Weekly from week 0 to week 12
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Food diary
Time Frame: Week 0 and week 12
|
Intervention adherence and compensation through 1) food diary analysis.
|
Week 0 and week 12
|
Accelerometer
Time Frame: Week 0 and week 12
|
Intervention adherence and compensation through accelerometer analysis.
|
Week 0 and week 12
|
Interview
Time Frame: Week 12
|
Detailed feedback on participant experience of commercial weight management program through qualitative interview and marketing survey.
|
Week 12
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Graham S Finlayson, PhD, University of Leeds
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Buckland NJ, Camidge D, Croden F, Myers A, Lavin JH, Stubbs RJ, Blundell JE, Finlayson G. Women with a low-satiety phenotype show impaired appetite control and greater resistance to weight loss. Br J Nutr. 2019 Oct 28;122(8):951-959. doi: 10.1017/S000711451900179X.
- Buckland NJ, Camidge D, Croden F, Lavin JH, Stubbs RJ, Hetherington MM, Blundell JE, Finlayson G. A Low Energy-Dense Diet in the Context of a Weight-Management Program Affects Appetite Control in Overweight and Obese Women. J Nutr. 2018 May 1;148(5):798-806. doi: 10.1093/jn/nxy041.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2014
Primary Completion (Actual)
December 1, 2015
Study Completion (Actual)
May 1, 2016
Study Registration Dates
First Submitted
December 10, 2013
First Submitted That Met QC Criteria
December 10, 2013
First Posted (Estimate)
December 16, 2013
Study Record Updates
Last Update Posted (Actual)
June 1, 2017
Last Update Submitted That Met QC Criteria
May 31, 2017
Last Verified
May 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LDS-2013-SLW
- KRISTAL No. (Other Identifier: RG.PSYC.100944)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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