Observation of Microvessels and Invasion in Early Colorectal Lesions by NBI

Observation of Microvessels and Invasion in Early Colorectal Lesions by Narrow Band Imaging:Combination With Microvessel Count and MMP-7 Expression

Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating invasion depth remains to be verified.The study is based on the hypothesis:NBI can predict histology and invasion depth,combined with the verification of microvessel count and MMP-7 expression.

Study Overview

• Status: Completed
• Conditions: Colorectal Neoplasms

Detailed Description

The microvessel count (MVC) is a classical method of assessing histologic grade.To verify whether NBI could predict histology through microvascular architecture,we measured lesion microvessels by immunohistochemistry.On the other hand,we applied immunohistochemistry of matrix metalloproteinase-7 (MMP-7) to validate the capability of NBI for estimating invasion depth.MMP-7 is directly involved in the processes of growth, invasion, and metastasis of colorectal cancer.Our target was to clarify the diagnostic accuracy of magnifying NBI in early colorectal lesions,combined with the verification of microvessel count and MMP-7 expression.

• Study Type: Observational
• Enrollment (Actual): 418

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients with early colorectal lesions

Description

Inclusion Criteria:

• patients of early colorectal lesions with capillary pattern(CP) type II&III,initially detected by white-light view and then examined by NBI with magnifying endoscopy.

Exclusion Criteria:

• lesions with CP type I;
• CP type III lesions with an obvious appearance of advanced cancer;
• lesions that had underwent biopsy;
• patients with inflammatory bowel disease(IBD) or familial adenomatous polyposis(FAP)
• patients with previous colorectal surgery;
• having conditions associated with cardiac,hepatic,renal,and coagulopathy diseases.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
NBI prediction for lesion histology and invasion	We will receive the histologic findings in two weeks after lesion treatment.Then we can compare NBI prediction with the final histologic type.	in two weeks after lesion treatment

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
immunohistochemical outcome of microvessel count and MMP-7	We will receive the immunohistochemical outcome in three days after immunohistochemistry.Then we can compare NBI prediction with immunohistochemical outcome	in three days after immunohistochemistry

Collaborators and Investigators

• Sponsor: Xiaobo Li
• Investigators: Principal Investigator: Xiaobo Li, Ph.D, Shanghai Ren ji Hospital

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (Actual): May 1, 2013
• Study Completion (Actual): December 1, 2013

Study Registration Dates

• First Submitted: January 25, 2014
• First Submitted That Met QC Criteria: January 25, 2014
• First Posted (Estimate): January 28, 2014

Study Record Updates

• Last Update Posted (Estimate): January 28, 2014
• Last Update Submitted That Met QC Criteria: January 25, 2014
• Last Verified: January 1, 2014

More Information

Terms related to this study

• Keywords: narrow band imaging,microvessels,matrix metalloproteinase-7
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: 12YZ036