Emerging Biomarkers in Hypertension

February 13, 2014 updated by: Giuseppe Derosa, University of Pavia

Evaluation of Some Emerging Biomarkers of Cardiovascular Risk Stratification in Hypertensive Patients: a 5-years Follow-up

First of all to evaluate the relationship between non-conventional biomarkers and essential hypertension; then to evaluate the effects of various anti-hypertensive drugs on blood pressure control and non-conventional biomarkers in naive hypertensive patients

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Observational

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Italy
      • Pavia, Italy, 27100
        • Recruiting
        • IRCCS Policlinico S.Matteo Foundation
        • Contact:
        • Sub-Investigator:
          • Pamela Maffioli, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 64 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Patients with naive essential hypertension aged < 65 years without previous cardiovascular events

Description

Inclusion Criteria:

  • essential hypertension
  • naive to treatment
  • < 65 years

Exclusion Criteria:

  • secondary hypertension
  • previous cardiovascular events

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Hypertensive patients
Hypertensive patients naive to hypertensive treatment
Drug: Anti-hypertensive drugs
healthy subjects

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood pressure reduction
Time Frame: 5 years
  • Systolic Blood Pressure (SBP)
  • Diastolic Blood Pressure (DBP)
5 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cardiovascular and metabolic biomarkers
Time Frame: 5 years
  • Lipoprotein (a) (Lp(a))
  • sRAGE (soluble Receptor for Advanced Glycation End-products)
  • sCD40L (soluble ligand of CD40)
  • MPO (myeloperoxidase)
5 years

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Evaluation of vascular stiffness
Time Frame: 5 years
- Aortic Pulse Wave velocity (PWV)
5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Pavia

Collaborators

IRCCS Policlinico S. Matteo

Investigators

  • Principal Investigator: Giuseppe Derosa, MD, PhD, University of Pavia

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2007

Primary Completion (Actual)

January 1, 2014

Study Registration Dates

First Submitted

February 11, 2014

First Submitted That Met QC Criteria

February 13, 2014

First Posted (Estimate)

February 17, 2014

Study Record Updates

Last Update Posted (Estimate)

February 17, 2014

Last Update Submitted That Met QC Criteria

February 13, 2014

Last Verified

November 1, 2007

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20070002649

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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