- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06187012
Hypertension Explored in Long-term Postpartum Follow-up in Later Life (HELPFUL)
Hypertension Explored in Long-term Postpartum Follow-up in Later Life (HELPFUL)
Study Overview
Status
Intervention / Treatment
Detailed Description
Women who experience high blood pressure during pregnancy are at increased risk of developing cardiac and vascular diseases later in life. They show changes in their heart, brain, and blood vessels long before they develop high blood pressure. The investigators therefore think that these changes develop slowly over the course of the life of the woman and establish their risk of later disease.
Through better understanding of the pattern of changes across multiple parts of the body over extended periods of time, the investigators aim to identify how advanced the underlying disease is for an individual and how the disease is likely to develop over the next few years. By comparing the rate of change across different parts of the body, the investigators can examine how one area affects another.
Data including images of the heart, brain and blood vessels will be acquired in women 10 to 25 years after their pregnancy. The initial analysis will focus on assessing differences between women who have had a normotensive pregnancy and those who have had a hypertensive pregnancy, both at a single timepoint and in changes within individuals over time.
This dataset will then be used in conjunction with previously acquired data in women who have experienced a hypertensive pregnancy to find out how patterns emerge across the whole body. The investigators will subsequently combine information from different measures at the same time and use the machine learning models to learn the patterns of change that occur as a person progresses from a healthy to a diseased state.
This will allow the researchers to identify patterns of hypertensive disease development and it may open doors to better interventions and therapies tailored towards individuals.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Katie Suriano
- Phone Number: 01865226845
- Email: helpful@cardiov.ox.ac.uk
Study Locations
-
-
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Oxford, United Kingdom, OX3 9DU
- Recruiting
- University of Oxford Department of Cardiovascular Medicine
-
Contact:
- Katie Suriano
- Phone Number: 01865226845
- Email: helpful@cardiov.ox.ac.uk
-
Principal Investigator:
- Paul Leeson, PhD MRCP FESC
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
Inclusion Criteria
- Participant is willing and able to give informed consent for participation in the study
- Female who had a pregnancy 10 to 25 years prior
- Able (in the investigator's opinion) and willing to comply with all study requirements.
- Adequate understanding of verbal and written English
Exclusion Criteria:
The participant may not enter the study if ANY of the following apply:
- Over 10 weeks pregnant during the course of the study
- Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status
- Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
For exclusion of MRI component only:
• Unsuitable for MRI based on the responses to the MRI screening form. The participant may still be included in other parts of the study.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Hypertensive pregnancy
|
Participants will attend one visit lasting approximately 3-4 hours on a single day or split over multiple visits to complete all measures.
Participants will first be asked to provide written informed consent for the study.
Participants' anthropometric measures (waist-to-hip ratio, height and weight, hip and waist circumference and left arm circumference and resting blood pressures will then be taken.
After this, the participants will undergo cardiopulmonary exercise testing, followed by magnetic resonance imaging, echocardiography, retinal imaging and vascular imaging of the ear.
The study visit will conclude with participants being provided with a wrist-worn physical activity monitor to wear for 7-9 days following the visit.
These monitors will provide objective measures of physical activity while people go about their normal activities.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cardiac right ventricular mass
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy. Index pregnancy is defined as the pregnancy which we first collected data from.
|
Magnetic resonance imaging assessment of cardiac right ventricular mass indexed to body surface area (g/m^2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy. Index pregnancy is defined as the pregnancy which we first collected data from.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cardiac left ventricular mass
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of cardiac left ventricular mass indexed to body surface area (g/m^2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac right ventricular end-diastolic volume
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of cardiac right ventricular end-diastolic volume indexed to body surface area (ml/m^2)
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac right ventricular stroke volume.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of cardiac right ventricular stroke volume indexed to body surface area (ml/m^2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac left-ventricular end-diastolic volume.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of cardiac left ventricular end-diastolic volume indexed to body surface area (ml/m^2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac left ventricular stroke volume
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of cardiac left ventricular stroke volume indexed to body surface area (ml/m^2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac right ventricular systolic function
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Echocardiography assessment of right ventricular systolic function: tricuspid annular plane systolic excursion (cm).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac right ventricular ejection fraction
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of right ventricular ejection fraction measured by cardiac magnetic resonance imaging (%).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac left ventricular systolic function
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Echocardiography assessment of left ventricular systolic function
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac left ventricular ejection fraction
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of left ventricular ejection fraction (%).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac right ventricular diastolic function
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Echocardiography assessment of right ventricular doppler early/late diastolic tricuspid inflow velocity ratio (E/A)
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac left ventricular diastolic function
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Echocardiography assessment of left ventricular doppler early/late diastolic mitral inflow velocity ratio (E/A).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiac left ventricular diastolic function
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Echocardiography assessment of left ventricular early doppler inflow velocity/peak early diastolic tissue velocity rate (E/e').
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Morphology of the right ventricles
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of the right ventricles morphology using cardiac statistical atlas and principal component analysis.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Morphology of the left ventricles
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of the left ventricles morphology using cardiac statistical atlas and principal component analysis.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Aortic distensibility
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Aortic distensibility by magnetic resonance imaging (10^-3 mmHg-1).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Aortic compliance
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Aortic/central blood pressure by cuff measurement (mmHg).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Intra-hepatic liquid content and steatohepatitis
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of the liver to quantify proton density fat fraction (%).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Hepatic fibrosis
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of the liver to quantify fibro-inflammatory status from iron corrected T1 (cT1 in ms)
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Renal volumes
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of renal volumes (ml/m^2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Renal fibro-inflammatory status
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of fibro-inflammatory status from T1 (ms)
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Renal blood perfusion
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Magnetic resonance imaging assessment of surrogate measures of blood perfusion from T2* (in ms).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Oxygen uptake across submaximal exercise
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiopulmonary exercise test to measure oxygen uptake (ml/kg/min).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Carbon dioxide exchange kinetics across submaximal exercise
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cardiopulmonary exercise test to measure respiratory exchange ratio (RER) calculated as carbon dioxide production divided by oxygen consumption.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Retinal arteriolar structure
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Central retinal arteriolar equivalent (CRAE) in micrometres measured using retinal imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Retinal venular structure
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Central retinal venular equivalent (micrometres) measured using retinal imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Retinal arteriolar-to venule diameter ratio (AVR)
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The ratio of average retinal arteriolar diameter and average retinal venous diameter (micrometres).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Ear microvascular structure.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Superior crus of anti-helix earlobe vascular calibre (micrometres) measured using ear vascular imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Lung function
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The ratio of FEV1 to FVC (FEV1/FVC) measured using spirometry.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Lung capacity
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The forced vital capacity (FVC in L) measured using spirometry.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Lung volume
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The forced expiratory volume in one second (FEV1 in L) measured using spirometry.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Objective measure of vigorous physical activity.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The amount of vigorous physical activity (h/week) measured using wrist worn accelerometer.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Objective measure of moderate to vigorous physical activity.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The amount of moderate to vigorous physical activity (h/week) measured using wrist worn accelerometer.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Total white matter volume
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Total white matter volumes (mm3) assessed on T1-weighted sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Total grey matter volume
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Total grey matter volumes (mm3) assessed on T1-weighted sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Subcortical brain volume of thalamus
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Subcortical brain volume of thalamus (mm3) assessed on T1-weighted sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Subcortical brain volume of hippocampus
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Subcortical brain volume of hippocampus (mm3) assessed on T1-weighted sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
White matter hyperintensities volume
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Total volume of white matter hyperintensities (mm3) assessed on T2-weighted sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
White matter hyperintensities count
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Total number of white matter hyperintensities on T2-weighted sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cerebral vessel lumen diameter
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cerebral vessel lumen diameter (micrometres) assessed on the time-of-flight sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cerebral vessel tortuosity
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The ratio of cerebral vessel tortuosity assessed on the time-of-flight sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cerebral vessel density
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Cerebral vessel density (mm3) assessed on the time-of-flight sequence of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Whole brain grey matter perfusion or cerebral blood flow (CBF)
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Whole brain grey matter perfusion/CBF (in ml/100g/min) assessed on arterial spin labelling of brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Arterial cerebral blood volume fraction
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Arterial cerebral blood volume fraction (%) assessed on arterial spin labelling on brain magnetic resonance imaging.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating vascular endothelial growth factor A as an angiogenic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating vascular endothelial growth factor A (pg/mL) measured from plasma blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating soluble endoglin as an angiogenic marker.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating soluble endoglin (ng/mL) measured from plasma blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating soluble fms-like tyrosine kinase-1 as an angiogenic marker.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating soluble fms-like tyrosine kinase-1 measured from plasma blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating total cholesterol as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of total cholesterol (mmol/L) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating high-density lipoprotein as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating high-density lipoprotein (mmol/L) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating low-density lipoprotein as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating low-density lipoprotein (mmol/L) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating triglycerides as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating triglycerides (mmol/L) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating fasting glucose concentration as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of fasting glucose (mmol/L) measured from whole blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating fasting insulin concentration as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of fasting insulin (pmol/L) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Insulin resistance index as a metabolic marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The index calculated as fasting glucose (mmol/L) x fasting insulin (ulU/mL)/22.5.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating C-reactive protein as an inflammatory marker.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of circulating C-reactive protein (mmol/L) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating soluble intercellular adhesion molecule-1 (slCAM-1) as an inflammatory marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of sICAM-1 (ng/mL) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Circulating soluble vascular adhesion molecule-1 (sVCAM-1) as an inflammatory marker
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The level of sVCAM-1 (ng/mL) measured from serum blood samples.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Body weight
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Body weight (kg)
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Body height
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Body height (m).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Body mass index (BMI)
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Body weight divided by the square of height (kg/m2).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Mid-arm circumference
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Mid-arm circumference (cm).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Waist-to-hip ratio
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The ratio of waist circumference (cm) to hip circumference (cm).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Systolic blood pressure
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Resting brachial blood pressure measurement (mmHg).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Diastolic blood pressure
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Resting brachial blood pressure measurement (mmHg).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Mean arterial pressure.
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The average arterial pressure from resting brachial blood pressure measurement (mmHg).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Pulse pressure
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The difference between systolic and diastolic blood pressure (mmHg).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Heart rate
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The frequency of the heart contractions per minute (bpm).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Smoking status
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
The number and percentage of current smokers.
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Alcohol consumption
Time Frame: Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Weekly alcoholic unit intake (units per week).
|
Participants will be recruited at 10 to 25 years post index pregnancy and assessed up to 40 years post index pregnancy
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Paul Leeson, University of Oxford
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 22/LO/0781
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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