Effects of Sedentary Behaviour on Metabolic Parameters

The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.

Study Overview

• Status: Completed
• Conditions: Sedentary Lifestyle; Type 2 Diabetes
• Intervention / Treatment: Other: Activity; Other: Inactivity

Detailed Description

There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions.

Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention.

This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • British Columbia
    • Vancouver, British Columbia, Canada, V5Z 1M9
      • Gerontology Research Lab

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 65 years of age or older
• type 2 diabetes managed with diet or oral hypoglycemic agents

Exclusion Criteria:

• using insulin to manage diabetes
• baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L
• any medical condition that would limit the ability to perform activity portion of the study
• people not comfortable exercising on a stationary bicycle
• subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Activity; During a 4 hour Meal Test subjects will cycle for 2 minutes every 20 minutes	Other: Activity; Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.
Other: Inactivity; During a 4 hour Meal Test study subjects will remain inactive (remain lying on a bed)	Other: Inactivity; Subjects will remain inactive (lying on a bed) for 4 hours.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Blood Pressure	every 60 minutes for 4 hours

Secondary Outcome Measures

Outcome Measure	Time Frame
C Reactive Protein	every 60 minutes for 4 hours
Insulin Levels	every 60 minutes for 4 hours
Blood glucose levels	every 60 minutes for 4 hours

Collaborators and Investigators

• Sponsor: University of British Columbia
• Investigators: Principal Investigator: Kenneth M Madden, MSc, MD, University of British Columbia

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2015
• Primary Completion (Actual): May 12, 2020
• Study Completion (Actual): September 1, 2021

Study Registration Dates

• First Submitted: March 13, 2014
• First Submitted That Met QC Criteria: March 14, 2014
• First Posted (Estimate): March 17, 2014

Study Record Updates

• Last Update Posted (Actual): November 2, 2022
• Last Update Submitted That Met QC Criteria: October 31, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Keywords: Exercise; Type 2 Diabetes; Older Adults; Sedentary Behaviour
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2
• Other Study ID Numbers: H13-01886

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No