- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02214654
A Pilot Study To Examine The Effects Of Ticagrelor To Protect Against Type 2 Diabetes-Induced Vascular Damage
Study Overview
Status
Conditions
Detailed Description
i- Verify the study inclusion and exclusion criteria at visit 1.
ii- Inform patients (verbally and in writing) and their caregivers (when considered necessary and with the patient's consent) of the characteristics of the study and confirm their agreement to participate by signing the informed consent document.
iii- Assist with patient assessment, record the information in the case report form. Based on the data we get from the case report form, assign the patient to the experimental or control group by stratified randomization.
ⅳ- At visit 2 to obtain blood sample from peripheral vessel and analyze the density of CECs,sCD40L and hs-CRP by flow cytometry (FCM), ELISA and particle-enhanced turbidimetric immunoassay.
ⅴ- All patients are given aspirin 100mg/qd orally and the experimental group given ticagrelor 90mg/bid while the control group clopidogrel 75mg/qd for 30 days.
ⅵ- At visit 3 repeating step ⅳ and making comparison on numbers of CECs and CD40L between the two groups, and finish a statistic analysis.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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Tianjin, China, 300192
- Tianjin First Central Hospital
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Contact:
- Xiaofei Wang, doctor
- Email: wangxiaofei@medmail.com.cn
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Tianjin
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Tianjin, Tianjin, China, 300192
- Tianjin First Central Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Provision of informed consent prior to any study specific procedures.
- A previous or new diagnosis of type 2 diabetes mellitus, document by one of following criteria:1)Hemoglobin A1c of ≥6.5% at diagnosis;2) Fasting plasma glucose (FPG) ≥126mg/dL (7.0 mmol/L);3) Two-hour plasma glucose≥200 mg/dL (11.1 mmol/L) during an oral glucose tolerance test (OGTT);4) with classic symptoms of hyperglycemia or hyperglycemic crisis, a random plasma glucose≥200mg/dL (11.1 mmol/L)( confirmed by repeat testing)
- A previous or new diagnosis of stable CAD according to ICD 10 for at least 6 months, document by following criteria: 1) Stable angina; 2) No AMI or NSTE-ACS within 1 month;and(or) 3) EKG with ischemic ST-segment and(or) T-wave change; and(or)4) coronory artery stenosis ≥50% viewed by coronary CTA or coronary angiography
- No medication history of clopidogrel/ticagrelor for at least 1 months
- Female or male, and any race, aged≥18 years, not pregnant.
Exclusion Criteria:
- Blood pressure>160/100 mm Hg;
- Hypercholesterolemia(LDL-c >240mg/dl);
- Hemoglobin A1c ≥ 10%;
- Platelet count less than 10*10^9/L or hemoglobin <10 g/dL;
- Intolerance or allergy to clopidogrel/ticagrelor or any of the excipients;
- Patient with known inflammatory conditions or those on anti-inflammatory drug therapy;
- Second and third degree atrioventricular block;
- chronic obstructive lung disease or asthma;
- Creatinine>2 mg/dl;
- Malignancy;
- Moderate or severe hepatic impairment;
- History of intracranial haemorrhage;
- Active pathological bleeding;
- Pregnancy or lactation;
- Any condition that increases the risk for noncompliance or being lost to follow-up;
- Medicine history of potent CYP3A4 inhibitor(ketoconazole, clarithromycin,etc.);
- No provision of informed consent.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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ticagrelor,clopidogrel,antiplatelet drugs
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
circulation endothelial cell
Time Frame: 1 month
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1 month
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Xiaofei Wang, doctor, Tianjin First Central Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ISSBRIL0241
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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