Phase II Study of Refametinib, a MEK Inhibitor, as Second-line Treatment in Advanced Biliary Tract Adenocarcinoma

Phase II Study of Refametinib, a MEK inhibitor, as second-line treatment in advanced biliary tract adenocarcinoma

Study Overview

• Status: Completed
• Conditions: Biliary Tract Cancer
• Intervention / Treatment: Drug: refametinib

Detailed Description

Refametinib will be administered orally at the starting dose of 50 mg twice daily on a continuous daily dosing schedule.

Self-administration of refametinib tablets will take place on an outpatient basis. Patients experiencing dose-limiting toxicity attributed to study medication should have at least 1-week treatment breaks inserted into the continuous daily dosing period as needed and/or may be interrupted or reduced depending on individual tolerability.

• Study Type: Interventional
• Enrollment (Actual): 4
• Phase: Phase 2

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. age ≥ 18
2. histologically or cytologically confirmed adenocarcinoma of biliary tract
3. unresectable or metastatic
4. ECOG performance status of 0~2
5. measurable lesion per RECIST 1.1 criteria
6. adequate marrow, hepatic, renal functions
7. normal range of cardiac function confirmed by echocardiogram within 1 year (LVEF ≥50)
8. Child-Pugh Class A in case of liver cirrhosis
9. One prior treatment of cytotoxic chemotherapy (including adjuvant treatment within 12 months)
10. Resolution of all acute toxic effects of any prior therapy to Common Toxicity Criteria for Adverse Events (CTCAE 4.03) ≤ grade 1.
11. provision of a signed written informed consent

Exclusion Criteria:

1. History of cardiac disease
2. Ongoing infection > Grade 2 according to NCI-CTCAE version 4.03. Hepatitis B is allowed if no active replication (defined as abnormal ALT >2xULN associated with HBV DNA >20,000 IU/mL) is present
3. Severe co-morbid illness and/or active infections including active hepatitis C and human immunodeficiency virus (HIV) infection
4. History of interstitial lung disease (ILD).
5. Any cancer curatively treated < 3 years prior to study entry, except cervical carcinoma in situ, treated basal cell carcinoma, and superficial bladder tumors (Staging: Ta, Tis and T1).
6. Renal failure requiring hemo- or peritoneal dialysis.
7. Clinically significant GI bleeding (CTCAE 4.03 grade 3 or higher) within 30 days prior to start of screening
8. Thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks) within 6 months prior to start of screening.
9. History of organ allograft, cornea transplantation will be allowed
10. Active CNS metastases not controllable with radiotherapy or corticosteroids
11. Visible retinal pathology as assessed by ophthalmologic exam that is considered a risk factor for RVO or CSR.
12. Known history of hypersensitivity to study drugs
13. Any condition that was unstable or which could jeopardize the safety of the patient and his/her compliance in the study
14. Non-healing wound, ulcer, or bone fracture.
15. Patients with seizure disorder requiring medication.
16. Use of strong inhibitors of CYP3A4 and strong inducers of CYP3A4 should be stopped 2 weeks before start of screening (see Appendix 1).
17. Acute steroid therapy or taper for any purpose (chronic steroid therapy is acceptable provided that the dose is stable for 1 month before start of screening and thereafter).
18. Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results.
19. Pregnant or lactating women. Women of childbearing potential not employing adequate contraception. Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to start of study treatment and a negative result must be documented before first dose of study drug.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: refametinib; refametinib medication	Drug: refametinib; Refametinib will be administered orally at the starting dose of 50 mg twice daily on a continuous daily dosing schedule.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Response rate	the rate of complete response and partial response among all evaluable patients	12months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
adverse events in each cycle were documented based on CTCAE v 4.03		24months
Duration of response	median time from response to progression	12months
Progression-free survival		6months
Exploratory correlative analysis	KRAS/PIK3CA mutation testing using BEAMing assay will be planned	15 days
Overall survival		12months

Collaborators and Investigators

• Sponsor: Samsung Medical Center

Study record dates

Study Major Dates

• Study Start (Actual): June 30, 2015
• Primary Completion (Actual): September 30, 2016
• Study Completion (Actual): October 13, 2016

Study Registration Dates

• First Submitted: November 18, 2014
• First Submitted That Met QC Criteria: January 19, 2015
• First Posted (Estimate): January 26, 2015

Study Record Updates

• Last Update Posted (Actual): April 26, 2017
• Last Update Submitted That Met QC Criteria: April 24, 2017
• Last Verified: April 1, 2017

More Information

Terms related to this study

• Keywords: second line
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms by Histologic Type; Neoplasms; Neoplasms by Site; Carcinoma; Neoplasms, Glandular and Epithelial; Digestive System Neoplasms; Biliary Tract Diseases; Adenocarcinoma; Biliary Tract Neoplasms
• Other Study ID Numbers: 2014-07-148