Posterior Cornea in Primary Open Angle Glaucoma

February 1, 2015 updated by: Pedro Gil, Centro Hospitalar do Baixo Vouga
Characterization of posterior corneal changes in primary open angle glaucoma patients, using Scheimpflug examination.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

A cohort of primary open angle glaucoma (POAG) patients is submitted to Scheimpflug Pentacam examination. The results are compared with a control group of age and central corneal thickness matched healthy subjects

Study Type

Observational

Enrollment (Anticipated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Portugal
      • Aveiro, Portugal, 3814-501
        • Recruiting
        • Centro Hospitalar Baixo Vouga
        • Contact:
        • Contact:
        • Principal Investigator:
          • Pedro Gil, MSc, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Cases from the Glaucoma Outpatient Clinic and controls from the General Ophthalmology Outpatient Clinic from a single ophthalmological center.

Description

Inclusion Criteria:

  • Primary open angle glaucoma, with the diagnosis supported on structural and functional complementary exams according to the current European Glaucoma Society guidelines
  • Healthy subjects from the General Ophthalmology Outpatient Clinic

Exclusion Criteria:

  • age inferior to 18 years old
  • primary closed angle glaucoma
  • secondary open angle glaucoma
  • previous intra-ocular surgery
  • known or suspected corneal disease
  • previous intra-ocular inflammation
  • previous ocular trauma

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Cases
Patients with primary open angle glaucoma, randomly selected from the Glaucoma Outpatient Clinic to be submitted to Pentacam examination
Procedure: Pentacam
Corneal topography using Scheimpflug Pentacam examination
Controls
Control group of age and central corneal thickness matched healthy subjects, randomly selected from the General Ophthalmology Outpatient Clinic to be submitted to Pentacam examination
Procedure: Pentacam
Corneal topography using Scheimpflug Pentacam examination

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mean posterior corneal elevation
Time Frame: Single point in time, at baseline at the moment of study enrollment
Mean posterior corneal elevation based on the relative elevation of the cornea related with the best-fit sphere
Single point in time, at baseline at the moment of study enrollment

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mean anterior corneal elevation
Time Frame: Single point in time, at baseline at the moment of study enrollment
Mean anterior corneal elevation based on the relative elevation of the cornea related with the best-fit sphere
Single point in time, at baseline at the moment of study enrollment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centro Hospitalar do Baixo Vouga

Investigators

  • Principal Investigator: Pedro Gil, MSc, MD, Centro Hospitalar Baixo Vouga

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2015

Primary Completion (Anticipated)

April 1, 2015

Study Completion (Anticipated)

April 1, 2015

Study Registration Dates

First Submitted

February 1, 2015

First Submitted That Met QC Criteria

February 1, 2015

First Posted (Estimate)

February 5, 2015

Study Record Updates

Last Update Posted (Estimate)

February 5, 2015

Last Update Submitted That Met QC Criteria

February 1, 2015

Last Verified

February 1, 2015

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CHBaixoVouga2

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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