Refractive and Corneal Topographic Characteristics in Upper Egypt Children With High Cylinder

Refractive and Corneal Topographic Characteristics in upper Egypt children with high cylinder: A cross sectional study

Study Overview

• Status: Completed
• Conditions: Corneal Ectasia
• Intervention / Treatment: Other: Pentacam and autorefractometry

Detailed Description

Astigmatism is defined as, a refractive condition in which refractive light fails to form a focus on the retina, it accounts for about 13% of refractive errors. It is frequent and correctable cause of visual impairment in children whether associated with spherical errors or not.

Astigmatism, is the refractive error of the highest clinical importance, being associated with reduced visual acuity with subsequent development of refractive amblyopia.

High cylinder in children belong to areas of hot and dry climates, makes exclusion of keratoconus is mandatory. Population in the African continent, the Mediterranean countries, Central and South America, and the Indian subcontinent usually have the habit of eye rubbing because of bothering symptoms of dryness, itching, atopy, allergy and vernal keratoconjunctivitis, which is the severe form of allergic conjunctivitis.

Eye rubbing causes thinning of keratocyte and increases the prevalence of keratoconus.

Keratoconus in children (diagnosed before the age of eighteenth) is less common but more aggressive than that of the adults, due to the dynamic nature of the young cornea. Few studies in the literature reported the prevalence and incidence of keratoconus in children.

Pentacam is an advanced instrument with a rotating Scheimpflug camera for scanning the anterior and posterior corneal surfaces. Its measurements of the corneal thickness and posterior elevation have been proved to be of high reproducibility and repeatability.

• Study Type: Observational
• Enrollment (Actual): 4000

Contacts and Locations

Study Locations

• Egypt
  • Sohag, Egypt
    • Elshimaa A.Mateen

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Children live in upper Egypt with high cylinder and no corneal scar.

Description

Inclusion Criteria:

- Upper Egypt children with high cylinder(refractive errorr).

Exclusion Criteria:

• Children below age of 7 years old (uncooperative), patients above age of 18 years old.Patients with corneal scars

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group 1 (control group); Children with normal Pentacam and with no refractive errors	Other: Pentacam and autorefractometry; Pentacam to detect corneal topographic changes. Auto-refractometry to assess refraction condition of the children
Group 2 (children with high cylinder and no corneal topographic abnormalities); Children with high cylinder without corneal topographic ectasia.	Other: Pentacam and autorefractometry; Pentacam to detect corneal topographic changes. Auto-refractometry to assess refraction condition of the children
Group 3 (Children with high cylinder and corneal ectatic changes).; Children with high cylinder and corneal ectatic changes	Other: Pentacam and autorefractometry; Pentacam to detect corneal topographic changes. Auto-refractometry to assess refraction condition of the children

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Values anterior and posterior corneal elevation values by pentacam.	Corneal topgraphic changes in children with high cylinder in upper Egypt	one year

Collaborators and Investigators

• Sponsor: Sohag University
• Investigators: Principal Investigator: Elshimaa A.Mateen, Assistant professor of ophthalmology, Sohag University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2023
• Primary Completion (Actual): January 30, 2024
• Study Completion (Actual): February 1, 2024

Study Registration Dates

• First Submitted: March 27, 2024
• First Submitted That Met QC Criteria: March 30, 2024
• First Posted (Actual): April 4, 2024

Study Record Updates

• Last Update Posted (Actual): April 9, 2024
• Last Update Submitted That Met QC Criteria: April 6, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathological Conditions, Anatomical; Dilatation, Pathologic
• Other Study ID Numbers: Soh-Med-23-01-29

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No