Multinational Survey of Epidemiology, Morbidity, and Outcomes in Intracerebral Hemorrhage (MNEMONICH)

Multinational Survey of Epidemiology, Morbidity, and Outcomes in Intracerebral Hemorrhage (MNEMONICH)

The aim of this project is development of a comprehensive, prospective, multinational, multicenter, hospital-based, data repository for patients with intracerebral hemorrhage.

Study Overview

• Status: Completed
• Conditions: Intracerebral Hemorrhage

Detailed Description

MNEMONICH is a disease-specific registry of prospectively collected data obtained from the integration and harmonization of preexisting single-center data sets. It was formed to provide clinician-scientists around the world a comprehensive database to direct future studies toward better understanding of ICH. MNEMONICH will help examine global variability in the prevalence of ICH and identify research priorities.

New data for MNEMONICH will be prospectively collected on a wide range of features including demographics, medical history, dates and times of symptom onset, presentation symptoms, hemodynamic signs, initial and chronic medical therapy, diagnostic imaging, laboratory and genetic analyses, pathological data, and surgical and medical management. Future research will be based upon ad hoc analysis of this data.

• Study Type: Observational
• Enrollment (Actual): 40

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized for ICH will be asked to provide their permission for the use of this information for retrospective research studies directed at ICH; such research to be conducted by the MNEMONICH investigators.

Description

Inclusion Criteria:

• Diagnosis of spontaneous intracerebral hemorrhage (ICH) met by clinical and imaging criteria
• Age 18 and above
• Able to consent

Exclusion Criteria:

• ICH due to trauma
• ICH due to vascular malformation or aneurysm
• ICH due to brain tumor
• ICH due to underlying infectious lesion (e.g., abscess)

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Modified Rankin Scale score	90 days

Collaborators and Investigators

• Sponsor: The University of Texas Health Science Center at San Antonio
• Collaborators: Northern Care Alliance NHS Foundation Trust; Maastricht University Medical Center; Manchester Metropolitan University; University of Western Ontario, Canada; University of Manchester; University of Medicine and Pharmacy Craiova; University of Central Florida; University of Rostock; Arcispedale Santa Maria Nuova-IRCCS; Hospital Interzonal de Agudos San Juan Bautista; Centre for Cardiovascular Medicine and Cerebrovascular Disease Prevention; San Camillo de' Lellis General Hospital
• Investigators: Study Director: Mario Di Napoli, MD, Centre for Cardiovascular Medicine and Cerebrovascular Disease Prevention; Principal Investigator: Mahmoud R Azarpazhooh, MD, Western University, Canada; Principal Investigator: Luca Masotti, MD, Arcispedale Santa Maria Nuova-IRCCS; Principal Investigator: Adrian R Parry-Jones, MBChB, PhD, University of Manchester and the Salford Royal NHS Foundation Trust; Principal Investigator: Aurel Popa-Wagner, MD, PhD, University of Rostock; Principal Investigator: Mark A Slevin, PhD, Manchester Metropolitan University; Principal Investigator: Craig J Smith, MBChB, MD, University of Manchester and the Salford Royal NHS Foundation Trust; Principal Investigator: Daniel A Godoy, MD, Hospital Interzonal de Agudos San Juan Bautista; Principal Investigator: Floris H Schreuder, MD, Maastricht University Medical Center; Principal Investigator: Michael W Hoffmann, MBChB, PhD, University of Central Florida

Publications and helpful links

General Publications

• Behrouz R, Azarpazhooh MR, Godoy DA, Hoffmann MW, Masotti L, Parry-Jones AR, Popa-Wagner A, Schreuder FH, Slevin MA, Smith CJ, Di Napoli M; MNEMONICH Steering Committee. The Multi-National survey on Epidemiology, Morbidity, and Outcomes iN Intracerebral Haemorrhage (MNEMONICH). Int J Stroke. 2015 Dec;10(8):E86. doi: 10.1111/ijs.12629. No abstract available.

Study record dates

Study Major Dates

• Study Start: November 1, 2015
• Primary Completion (Actual): August 1, 2016
• Study Completion (Actual): August 1, 2016

Study Registration Dates

• First Submitted: September 30, 2015
• First Submitted That Met QC Criteria: September 30, 2015
• First Posted (Estimate): October 2, 2015

Study Record Updates

• Last Update Posted (Estimate): December 9, 2016
• Last Update Submitted That Met QC Criteria: December 8, 2016
• Last Verified: December 1, 2016

More Information

Terms related to this study

• Keywords: Stroke; Cerebrovascular disease; Hemorrhagic stroke; Intracerebral hemorrhage; Intraparenchymal hemorrhage
• Additional Relevant MeSH Terms: Pathologic Processes; Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Intracranial Hemorrhages; Hemorrhage; Cerebral Hemorrhage
• Other Study ID Numbers: HSC20150655H