Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Study Overview

• Status: Unknown
• Conditions: Lung Disease,Obstructive
• Intervention / Treatment: Drug: Salbutamol Aerosol; Drug: No drugs

• Study Type: Interventional
• Enrollment (Anticipated): 120
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Xue Wang, MB; Phone Number: 0086-10-85231543; Email: rtxue2013@sina.com
• Study Contact Backup: Name: Sun Bing, MD; Phone Number: 86013911151075; Email: ricusunbing@126.com

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100020
      • Recruiting
      • Department of respiratory and critical care medicine,Beijing Chao-yang Hospital
      • Contact: Bing Sun, MD; Phone Number: 86013911151075; Email: ricusunbing@126.com
      • Contact: Xue Wang, MB; Phone Number: 0086-10-85231543; Email: rtxue2013@sina.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Acute exacerbation of chronic obstructive pulmonary disease
• The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours

Exclusion Criteria:

• asthma
• has received tracheotomy
• long term mechanical ventilation (which has been accepted for more than 21 days).
• severe pneumonia
• Patients who cannot use a patient with bronchial dilation
• there's a taboo on the use of a sedative.
• refusal to participate in the study
• 48 hours to pull out the tube

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Atomization inhalation; First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group	Drug: Salbutamol Aerosol; Other Names: Ammonium bromide bromide aerosol
Active Comparator: Without atomization inhalation; First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group	Drug: No drugs

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
airway resistance	The first test of bronchial dilatation	1 day
Respiratory mechanics index:PEEPi		1 day

Secondary Outcome Measures

Outcome Measure	Time Frame
length of hospital stay	30 days
Costs of hospitalization expenses	30 days
Mechanical ventilation time	28 days
Routine blood test:Eosinophilic cells	7days

Collaborators and Investigators

• Sponsor: snow
• Collaborators: Primary-investigator,Bing Sun
• Investigators: Principal Investigator: Bing Sun, Beijing Chao Yang Hospital

Publications and helpful links

General Publications

• Li Y, Chen Y, Wang P. Application of impulse oscillometry and bronchial dilation test for analysis in patients with asthma and chronic obstructive pulmonary disease. Int J Clin Exp Med. 2015 Jan 15;8(1):1271-5. eCollection 2015.

Study record dates

Study Major Dates

• Study Start: October 1, 2013
• Primary Completion (Anticipated): October 1, 2016

Study Registration Dates

• First Submitted: October 11, 2015
• First Submitted That Met QC Criteria: October 29, 2015
• First Posted (Estimate): October 30, 2015

Study Record Updates

• Last Update Posted (Estimate): October 30, 2015
• Last Update Submitted That Met QC Criteria: October 29, 2015
• Last Verified: October 1, 2015

More Information

Terms related to this study

• Keywords: Chronic obstructive pulmonary disease; Mechanical ventilation; Airway resistance; Bronchial dilation test
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Physiological Effects of Drugs; Adrenergic Agents; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Autonomic Agents; Peripheral Nervous System Agents; Adrenergic Agonists; Anticonvulsants; Bronchodilator Agents; Anti-Asthmatic Agents; Respiratory System Agents; Reproductive Control Agents; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Tocolytic Agents; Albuterol; Bromides
• Other Study ID Numbers: 2013-10-COPD