- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02703064
Furocyst - Poly Cystic Ovary Syndrome Study
To Study the Efficacy and Safety of Furocyst in Poly Cystic Ovary Syndrome Patients (PCOS)
Study Overview
Detailed Description
The symptoms of PCOS are anovulation, resulting in irregular menstruation (amenorrhea and oligomenorrhea) ovulation-related infertility, and polycystic ovaries, often associated with obesity, Type 2 diabetes, and high cholesterol levels. The level of serum insulin and insulin resistance are higher in women with PCOS (Hyperinsulinemia).Insulin resistance, defined as the decreased insulin mediated glucose utilization it is more common in women with PCOS up to 50 % in both obese and non obese women . It has also been recognized that some women with this syndrome will have PCO without clinical evidence of androgen excess, but will display evidence of ovarian dysfunction .
It is believed to be that, the Hyperinsulinemia of PCOS stimulates the androgens production and increase the activity by decreasing the sex hormone binding globulin (SHBG) thus increasing the free active testosterone level and by the activating the cytochrome P 450 C 17 alpha enzymatic system that controls androgens production.
The diagnosis of PCOS is based on Hyperandrogenism and chronic anovulation in the absence of specific pituitary or adrenal disease , and have disrupted ovulatory function with chronic oligomenorrhea (cycle length > 35 day) or amenorrhea (cycle length > 12 week) and typical appearance of polycystic ovaries by ultrasound according to the criteria of the Rotterdam consensus meeting 2003 for diagnosis of PCOS. The different diagnostic tests needed to adequately assess for the possibility of PCOS e.g. Pregnancy test, TSH level (for Hyperthyroidism), Prolactin test (for Hyperprolactinemia), Total testosterone (for ovarian tumor) and some tests forevaluating the insulin resistance syndrome in women: Waist circumference (>88 cm), Triglycerides (>150 mg/dL), HDL Cholesterol (<50 mg/dL), Blood pressure (>130/85) and Fasting glucose (>110 mg/dL). Fasting glucose- to- insulin ratio and 2 hour oral glucose tolerance test (2h- OGTT 140 - 199 mg/dL) may be better predictor of insulin resistance .
The management of the PCOS is symptoms specific e.g.
- Oral contraceptives, periodic progesterone withdrawal for the control of irregular menstruation.
Oral contraceptives, Metformin and anti-androgens (Spironolactone) for the
Hirsutism.
- Clomiphene citrate, Metformin and thiazolidinediones for infertility. A recent study shown that, the combination of Metformin plus Clomiphene citrate should be considered as the First line treatment for infertile women with PCOS .
- Metformin and lifestyle modification for the insulin resistance and diabetes mellitus.
All these management options are only for "acute" not for "chronic". The long-term management approach for the PCOS is needed which will be based on management of most affecting factor insulin resistance.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
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Uttar Pradesh
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Lucknow, Uttar Pradesh, India, 226003
- Dept of Obs & Gynae, King George's Medical University, Lucknow, UP, India
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Premenopausal women between 18-45 years of age and BMI less than 42
- Diagnosed with PCOS by Rottadom Criteria
- Adequate hepatic, renal, Cardiac and hematological functions.
- Patients willing to Participate and give informed consent in writing as well as in audio-visual form for the study.
- Stable weight for last two months (Change of weight<3kg)
Exclusion Criteria:
- Male
- Post menopausal women
- Women with hysterectomy
- Hyperprolactinemia
- Patients with congenital adrenal hyperplasia
- Patients suffering from Cushing's syndrome
- Acute or chronic Medical illness including Hepatic, Cardiac or renal insufficiency, COPD,Gastrointestinal Disorders
- Uncontrolled Hypertensive or known Diabetics on drugs
- Use of oral contraceptives or HRT for last three months
- Smoking or drug addicts or with psychiatric illness
- Patients diagnosed with androgen secreting tumors.
- Patients with thyroid dysfunction (T3, T4 level is higher than that in normal women of reproductive age)
- Patients with Hypo-gonadotropic and Hypo-gonadism (central origin of ovarian dysfunction)
- Pregnant or lactating mothers
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Furocyst
Furocyst 500mg capsule, BD
|
Furocyst caps BD
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Reduction in Overian volume & Number of overian Cysts
Time Frame: 12 weeks
|
12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Restoration of normal menstrual cycle
Time Frame: 12 weeks
|
12 weeks
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Dr. Pushpalata Sankhwar, M.S., Dept of Obs & Gynae,King George's Medical University, Lucknow, UP, India
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Protocol No. CR-PCOS/1-15
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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