Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth

Objective:

Premolar autotransplantation represents an effective therapeutic option for the treatment of juvenile dentition in traumatic dental injury with tooth loss. Numerous studies report on the osteoinductive potency of the method, however, to date no quantitative data has been provided. The objective of this prospective clinical study was to quantitatively assess the bone and soft tissue levels after autogenous premolar transplantation by clinical and radiographic parameters.

Materials/Methods:

In the study 26 premolars were transplanted in 20 patients after traumatic dental injury (n=10) or tooth aplasia (n=16) in the upper front. Standard clinical parameters were evaluated. Based on a standardized photo documentation, the relative soft tissue level was measured in comparison to the healthy adjacent teeth. Radiographic findings involved the evaluation of root resorption, pulp canal obliterations and the relative bone height. Patient satisfaction was determined using a standardized questionnaire.

Study Overview

• Status: Completed
• Conditions: Traumatic Dental Injury; Tooth Aplasia
• Intervention / Treatment: Procedure: premolar autotransplantation

• Study Type: Observational
• Enrollment (Actual): 20

Contacts and Locations

Study Locations

• Germany
  • Sauerbruchstraße 48
    • Munich, Sauerbruchstraße 48, Germany, 81377
      • MKG Praxisklinik

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 10 years to 17 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients (mean age 13.6, f:10, m:10) suffering from tooth loss in the anterior maxilla (13-23). Thirteen patients suffered from traumatic dental injury (TDI) with subsequent tooth loss (n=16 transplants). In 7 patients, aplasia of teeth in region 13 to 23 was present (n=10 transplants).

Description

Inclusion Criteria:

• premolar transplantation after tooth loss in the anterior maxilla (13-23) by aplasia or trauma

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Transplant survival	Evaluation by Kaplan-Meier-Estimator.	2006-2014
Soft tissue development	Measurement by standardized clinical documentation.	2006-2014
Bone development	Measurement by radiographic evaluation.	2006-2014
Sensibility	Assessment of clinical sensibility.	2006-2014
Root resorptions	Radiographic evaluation.	2006-2014
Pulp obliteration	Radiographic evaluation.	2006-2014

Collaborators and Investigators

• Sponsor: MKG-Praxisklinik

Study record dates

Study Major Dates

• Study Start: August 1, 2012
• Primary Completion (Actual): October 1, 2014
• Study Completion (Actual): October 1, 2014

Study Registration Dates

• First Submitted: March 22, 2016
• First Submitted That Met QC Criteria: April 12, 2016
• First Posted (Estimate): April 15, 2016

Study Record Updates

• Last Update Posted (Estimate): April 15, 2016
• Last Update Submitted That Met QC Criteria: April 12, 2016
• Last Verified: April 1, 2016

More Information

Terms related to this study

• Other Study ID Numbers: Premolar transplantation

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO