The Relationship Between White Matter Hyperintensity With Cognition and Emotion

June 10, 2017 updated by: Minming Zhang, Zhejiang University

White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

China
- Zhejiang
  - Hangzhou, Zhejiang, China, 310009
    - Recruiting
    - The 2nd Affiliated Hospital of Zhejiang University, School of Medicine,
    - Contact:
      
      Xinfeng Yu, PhD
      
      Phone Number: 86-18758187391
      
      Email: angek-4125@163.com
    - Principal Investigator:
      
      Minming Zhang, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

31 years to 81 years (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

aged patients with white matter hyperintensity

Description

Inclusion criteria:

white matter hyperintensity visible on T2 fluid-attenuated inversion recovery images;
age between 35 to 80 years;
without stroke lesion (except lacunar infarction) on current diffusion weighted images;
without a history of multiple sclerosis, Alzheimer's disease, Parkinson's disease and head trauma.

Exclusion criteria:

white matter lesions of nonvascular origin (immunological-demyelinating, metabolic, toxic, infectious, other);
intracranial hemorrhage;
with severe head motion on magnetic resonance images

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: Cohort
Time Perspectives: Prospective

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
Control
White matter hyperintensity

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Fazekas Scale of white matter hyperintensity Time Frame: 1 year	1 year
Mini-Mental State Examination (MMSE) Time Frame: 1 year	1 year
Hamilton Depression Scale (HAMD) Time Frame: 1 year	1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhejiang University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2014

Primary Completion (Anticipated)

December 1, 2019

Study Completion (Anticipated)

December 1, 2019

Study Registration Dates

First Submitted

May 2, 2016

First Submitted That Met QC Criteria