Characteristics of Rheumatoid Arthritis Patients With Atlantoaxial Synovitis Detected by Plain X-ray and MRI (MRI)

January 11, 2020 updated by: Nisreen Adel Abbas, Assiut University

Characteristics of Rheumatoid Arthritis Patients With Asymptomatic Versus Symptomatic Atlantoaxial Joint Affection Detected by Plain X-ray and Magnetic Resonance Imaging

This study detects the presence of atlantoaxial joint affection in symptomatic versus asymptomatic rheumatoid arthritis patients revealed by plain X-ray and magnetic resonance imaging of the cervical spine

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Detailed Description

Atlantoaxial joint affection in rheumatoid arthritis patients may have life-threatening complications if not detected early. It may not be detected unless it becomes symptomatic. However, asymptomatic atlantoaxial joint affection is not uncommon. Investigators will try to detect atlantoaxial joint affection at an early stage and its relation to symptomatology and other disease criteria. So investigators will use conventional plain X-ray examination combined with magnetic resonance imaging of the cervical spine to detect soft tissue as well as bony changes of this condition.

Study Type

Interventional

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Rheumatoid arthritis patients complaining or not complaining of atlantoaxial affection symptomatology

Exclusion Criteria:

  • Pregnant females
  • Patients with pacemakers or metallic bony plates.
  • Patients that have claustrophobia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Screening
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Symptomatic atlantoaxial joint affection
Undergo plain X-ray and magnetic resonance imaging
Radiation: Plain X-ray
antero-posterior, lateral neutral, flexion, extension and open-mouth views
Radiation: Magnetic resonance imaging
Magnetic resonance imaging sagittal T1W,T2W and STIR, axial T1W and coronal T2W and post contrast sagittal and axial sequences
Other: Asymptomatic atlantoaxial joint aff.
Undergo plain X-ray and magnetic resonance imaging
Radiation: Plain X-ray
antero-posterior, lateral neutral, flexion, extension and open-mouth views
Radiation: Magnetic resonance imaging
Magnetic resonance imaging sagittal T1W,T2W and STIR, axial T1W and coronal T2W and post contrast sagittal and axial sequences

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Prevelance of atlantoaxial joint affection in clinically and laboratory proven rheumatoid arthritis patients
Time Frame: 3 months
Prevelance of atlantoaxial joint affection in symptomatic versus asymptomatic rheumatoid arthritis patients
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Investigators

  • Principal Investigator: Nisreen A Abbas, Doctor, Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2016

Primary Completion (Anticipated)

January 1, 2017

Study Completion (Anticipated)

February 1, 2017

Study Registration Dates

First Submitted

May 11, 2016

First Submitted That Met QC Criteria

May 12, 2016

First Posted (Estimate)

May 17, 2016

Study Record Updates

Last Update Posted (Actual)

January 14, 2020

Last Update Submitted That Met QC Criteria

January 11, 2020

Last Verified

January 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Rheumatoid AAJ

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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