Mental Time Travel and Identity in Bipolar Disorder Patients

June 7, 2016 updated by: CHU de Reims

Self-defining Memories and Future Projections in Bipolar Disorder Patients

Self-defining memories (SDMs) are memories that are still important today to understand who the investigators are and participate to the maintain of personal identity. SDMs are also linked to our capacity to project ourselves into the future. In bipolar disorder, life events play an important role in the course and outcome of the disease. the study is the first to investigate SDMs and self-defining future projections in a population of remitted patients with bipolar disorder.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Study design: case / control study in inclusion prospective, single center. population:

  • A group of 30 patients aged 18 to 60 years and followed in the psychiatry department of adult CHU Reims for bipolar disorder type I (DSM-IV criteria).
  • A group of 30 control subjects with no personal or family history of severe psychiatric disorder (bipolar disorder, schizophrenia or schizoaffective disorder), recruited from the staff of the University Hospital of Reims, the medical faculty of Reims or Marnais center health promotion of Reims, via the intranet and paper display.

The two groups will be matched for age (± 3 years), sex and educational level (± 2 years).

Plan of investigation: the study will be done in two visits:

  • The first visit by a psychiatrist for:

    • information on the objectives and the methods of research, verification criteria for inclusion and non-inclusion and participation of obtaining consent (written consent)
    • comprehensive psychiatric evaluation and procurement different scales (anxiety scale, Hamilton depression scale, evaluation of verbal IQ, ...).
  • 2nd visit, a maximum of 15 days after the first visit by a psychologist, neuropsychologist for the award of the memories of love and future projections defining self: the experimenter asks the subjects to relate memories 3 and 3 future projections. It is important personal events that arouse strong emotions and that the subjects often think.

Memories and projections reported by the subjects are then classified according to their emotional valence, their content, significance and degree of integration itself.

Study Type

Interventional

Enrollment (Anticipated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Reims, France, 51092
        • Recruiting
        • CHU Reims
        • Contact:
          • Delphine RAUCHER-CHENE
        • Contact:
          • Sarah BARRIERE

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

BD patients :

  • Men or women, right-handed, with a diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria, aged from 18 to 60 years-old
  • Native French speaker
  • Affiliated to the social security
  • Accepting the study after reading the information note and signing the consentment form

Healthy Controls (HC):

  • Men or women, right-handed, aged from 18 to 65 years-old
  • Native French speaker
  • Affiliated to the social security
  • Accepting the study after reading the information note and signing the consentment form

Exclusion criteria

BD patients :

  • A recent alcohol and/or drug abuse or dependence
  • A significant general medical illness, including neurological disorders or head trauma
  • A sensorial impairment (visual and/or hearing)

HC:

  • A personal or first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV
  • A recent alcohol and/or drug abuse or dependence
  • A significant general medical illness, including neurological disorders or head trauma
  • A sensorial impairment (visual and/or hearing)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Healthy Controls
Behavioral: psychological tests
EXPERIMENTAL: Bipolar Disorder patients
Behavioral: psychological tests

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
psychological test : Mini International Neuropsychiatric Interview (M.I.N.I.)
Time Frame: Day 01
Day 01
psychological test : State - Trait Anxiety Inventory Form Y
Time Frame: day 15
day 15
psychological test : Hamilton Depression Scale (HAM-D)
Time Frame: Day 01
Day 01
psychological test : Mill Hill Vocabulary Scale
Time Frame: day 15
day 15

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

CHU de Reims

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2013

Primary Completion (ANTICIPATED)

October 1, 2016

Study Completion (ANTICIPATED)

October 1, 2016

Study Registration Dates

First Submitted

May 12, 2016

First Submitted That Met QC Criteria

June 7, 2016

First Posted (ESTIMATE)

June 8, 2016

Study Record Updates

Last Update Posted (ESTIMATE)

June 8, 2016

Last Update Submitted That Met QC Criteria

June 7, 2016

Last Verified

May 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PA12064

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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