Audition After a Lesion and in Migraine. (AuditionPostLesion)

August 27, 2025 updated by: Hospices Civils de Lyon

Consequences of a Brain Lesion or of Migraine on Auditory Processing: Attention, Memory and Emotion

The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

262

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Bron, France, 69500
        • Unité 201, Hôpital Neurologique
      • Lyon, France, 69004
        • Service Explorations Fonctionnelles Neurologiques, Hôpital de la Croix-Rousse

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 76 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age from 18 to 80
  • MEG/MRI compatibility
  • Motivation to participate efficiently in the study
  • No severe hearing loss
  • Informed consent to participate in the study
  • Affiliation to social security
  • For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion
  • For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine
  • Healthy participants: absence of neurological and psychiatric disorders

Exclusion Criteria:

  • Age below 18 or above 80
  • MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
  • MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
  • Pregnant or breast-feeding women

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Brain-damaged patients
Other: Neuropsychological tests
Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.
Other: Neurophysiological tests
Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.
Experimental: Control participants
Other: Neuropsychological tests
Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.
Other: Neurophysiological tests
Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.
Experimental: Migraine patients
Other: Neuropsychological tests
Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.
Other: Neurophysiological tests
Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percentages of correct responses in Neuropsychological tests
Time Frame: up to 2 months
up to 2 months
reaction times in Neuropsychological tests
Time Frame: up to 2 months
up to 2 months

Secondary Outcome Measures

Outcome Measure
Time Frame
Event-Related Potentials (EEG) in Neurophysiological tests
Time Frame: up to 2 months
up to 2 months
Event-Related Fields (MEG) in Neurophysiological tests
Time Frame: up to 2 months
up to 2 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospices Civils de Lyon

Investigators

  • Principal Investigator: Norbert NIGHOGHOSSIAN, MD, Unité 201, Hôpital Neurologique, Hospices Civils de Lyon

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 6, 2015

Primary Completion (Actual)

September 9, 2020

Study Completion (Actual)

September 9, 2020

Study Registration Dates

First Submitted

May 27, 2016

First Submitted That Met QC Criteria

June 6, 2016

First Posted (Estimated)

June 7, 2016

Study Record Updates

Last Update Posted (Estimated)

September 4, 2025

Last Update Submitted That Met QC Criteria

August 27, 2025

Last Verified

August 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 69HCL14_0202
  • 2014-A01289-38 (Other Identifier: ID-RCB)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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