Beta-alanine and Elder Endurance

The Interactive Effects Of Beta-Alanine Supplementation and Resistance Training on Muscular Endurance in Older Adults

The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.

Study Overview

• Status: Completed
• Conditions: Physical Endurance
• Intervention / Treatment: Dietary supplement: Placebo; Dietary supplement: Beta-alanine; Behavioral: Muscular endurance exercise

• Study Type: Interventional
• Enrollment (Actual): 27
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Florida
    • Coral Gables, Florida, United States, 33146
      • Max Orovitz Laboratories

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• 60-90 years of age
• Living independently (not residing in an assisted living facility)
• Through testing are found not to have sarcopenia
• Gait speed > 1 m/s
• Skeletal Muscle Index > 37% in men and > 27.6 % in women
• Exclusion Criteria
• Responding with a "yes" to any question on the PAR-Q.
• Are currently pregnant, or plan to try and become pregnant during the study
• Functional impairments that could impede the person's ability to participate in a resistance training program
• Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis.
• Are currently enrolled in a regular exercise program (more than once per week)
• Current or recent smoker
• Use of medication containing corticosteroids
• Mini-mental score of 21 or below
• Severe musculoskeletal impairment
• Uncontrolled chronic disease
• Major depression
• Severe vestibular problems

Exclusion Criteria:

• Adults unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Prisoners

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Beta-alanine and muscular endurance exercise; Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks	Dietary supplement: Beta-alanine; Behavioral: Muscular endurance exercise
Experimental: Beta-alanine without muscular endurance training; Receive 3.2 g/day beta-alanine with no endurance resistance training for 12 weeks	Dietary supplement: Beta-alanine
Placebo Comparator: Placebo and muscular endurance exercise; Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks	Dietary supplement: Placebo; Behavioral: Muscular endurance exercise
Placebo Comparator: Placebo without muscular endurance training; Receive similar dextrose placebo with no endurance resistance training for 12 weeks	Dietary supplement: Placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Performance of Daily Activities	Short Physical Functional Performance test	baseline, 12 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Body Fat	Body fat assessment via bioimpedance	baseline, 12 weeks
Change in Muscular Endurance	20 repetitions to measure decline in muscular power across repetitions	baseline, 12 weeks
Change in Muscular Strength	Maximal weight that could be lifted one time (1RM)	baseline, 12 weeks

Collaborators and Investigators

• Sponsor: University of Miami
• Investigators: Principal Investigator: Joseph F. Signorile, PhD, University of Miami

Study record dates

Study Major Dates

• Study Start: June 1, 2016
• Primary Completion (Actual): June 1, 2016
• Study Completion (Actual): June 1, 2016

Study Registration Dates

• First Submitted: June 28, 2016
• First Submitted That Met QC Criteria: June 28, 2016
• First Posted (Estimate): July 1, 2016

Study Record Updates

• Last Update Posted (Actual): September 5, 2017
• Last Update Submitted That Met QC Criteria: August 31, 2017
• Last Verified: August 1, 2017

More Information

Terms related to this study

• Keywords: Elderly; Supplementation; Neuromuscular
• Other Study ID Numbers: 20140412

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No